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CYP4F2
Gene Name
cytochrome P450, family 4, subfamily F, polypeptide 2
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Cytoplasm
Endoplasmic Reticulum Membrane
Apical Plasma Membrane
Intracellular Membrane-bounded Organelle
Molecular Function
Iron Ion Binding
Protein Binding
Arachidonic Acid Epoxygenase Activity
Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, NAD(P)H As One Donor, And Incorporation Of One Atom Of Oxygen
Alkane 1-monooxygenase Activity
Heme Binding
Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity
Leukotriene-B4 20-monooxygenase Activity
Arachidonic Acid Omega-hydroxylase Activity
Alpha-tocopherol Omega-hydroxylase Activity
Tocotrienol Omega-hydroxylase Activity
Biological Process
Very Long-chain Fatty Acid Metabolic Process
Long-chain Fatty Acid Metabolic Process
Renal Water Homeostasis
Pressure Natriuresis
Icosanoid Metabolic Process
Leukotriene Metabolic Process
Xenobiotic Metabolic Process
Blood Coagulation
Regulation Of Blood Pressure
Drug Metabolic Process
Arachidonic Acid Metabolic Process
Epoxygenase P450 Pathway
Negative Regulation Of Blood Coagulation
Negative Regulation Of Icosanoid Secretion
Positive Regulation Of Icosanoid Secretion
Leukotriene B4 Catabolic Process
Vitamin E Metabolic Process
Menaquinone Catabolic Process
Vitamin K Biosynthetic Process
Phylloquinone Catabolic Process
Vitamin K Catabolic Process
Small Molecule Metabolic Process
Sodium Ion Homeostasis
Oxidation-reduction Process
Omega-hydroxylase P450 Pathway
Pathways
Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B)
Metabolism of lipids and lipoproteins
Metabolic disorders of biological oxidation enzymes
Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A)
Phase 1 - Functionalization of compounds
Arachidonic acid metabolism
Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4)
Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56)
Cytochrome P450 - arranged by substrate type
Biological oxidations
Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD)
Defective FMO3 causes Trimethylaminuria (TMAU)
Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)
Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX)
Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4)
Eicosanoids
Synthesis of Leukotrienes (LT) and Eoxins (EX)
Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA)
Miscellaneous substrates
Defective CYP1B1 causes Glaucoma
Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5)
Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3)
Defective CYP19A1 causes Aromatase excess syndrome (AEXS)
Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5)
Fatty acids
Defective CYP24A1 causes Hypercalcemia, infantile (HCAI)
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)
Defective MAOA causes Brunner syndrome (BRUNS)
Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency)
Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)
Drugs
Diseases
GWAS
Acenocoumarol maintenance dosage (
19578179
)
Metabolite levels (
23281178
)
Response to Vitamin E supplementation (
22437554
)
Vitamin E levels (
21729881
)
Warfarin maintenance dose (
20833655
19300499
)
Protein-protein Interactions
2 interactors:
CYB5A
PDR
Entrez ID
8529
HPRD ID
05112
Ensembl ID
ENSG00000186115
Uniprot IDs
P78329
PDB IDs
Enriched GO Terms of Interacting Partners
?
L-ascorbic Acid Metabolic Process
Response To Cadmium Ion
Water-soluble Vitamin Metabolic Process
Vitamin Metabolic Process
Hydrogen Ion Transmembrane Transport
Proton Transport
Monosaccharide Metabolic Process
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