SHC3 and YPEL5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SHC3	YPEL5
Description		SHC adaptor protein 3	yippee like 5
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane	Ubiquitin Ligase Complex Spindle Pole Extracellular Region Nucleus Cytoplasm Centrosome Cytoskeleton Midbody Mitotic Spindle Pole Tertiary Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	Phosphotyrosine Residue Binding Protein Binding Receptor Tyrosine Kinase Binding	Protein Binding Metal Ion Binding
	Biological Process	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Central Nervous System Development Intracellular Signal Transduction	Cell Population Proliferation
Pathways		Signalling to RAS Signalling to RAS RAF/MAP kinase cascade RET signaling	Neutrophil degranulation
Drugs
Diseases
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847) Logical memory (delayed recall) in Alzheimer's disease dementia ( 29274321) Monocyte count ( 32888494) Pelvic organ prolapse (moderate/severe) ( 26545240) Response to statins (LDL cholesterol change) ( 22331829) Superior parietal cortex volume ( 31530798) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)	Celiac disease and Rheumatoid arthritis ( 26546613) Low density lipoprotein cholesterol levels ( 33339817) Total cholesterol levels ( 33339817) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535)
Interacting Genes		58 interacting genes: ALK ANKRD10 APP AR ARHGAP32 ASPG AXL BMF CCNC CDCA4 CEACAM6 COPS6 CT55 DOK3 EGFR ERBB2 ERBB3 ERBB4 FLT4 FTO GAB1 GOLGA2 GOLGA6L9 GRB2 KIT KRT31 KRT33B KRT34 KRT35 KRT39 KRT40 KRT86 MET NTRK1 NTRK2 PMF1 PNMA1 PPP1R16B PRKAR1B PSMD8 REL RET SH3GL3 SMYD3 STX11 TRAF1 TRAF2 TRIM35 TRIM54 TSC1 UBAP2 USHBP1 USP54 VPS28 WWOX YPEL3 YPEL5 ZMYND12	11 interacting genes: CTDSP1 DDIT4L FBXO7 GSC2 MAPKBP1 PFDN5 PLAGL2 PSMA1 SHC3 TRAF5 ZNF655
Entrez ID		53358	51646
HPRD ID		12005	18312
Ensembl ID		ENSG00000148082	ENSG00000119801
Uniprot IDs		Q92529	P62699
PDB IDs			8QBN
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Activity Receptor Complex Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Structural Constituent Of Skin Epidermis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Programmed Cell Death Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Positive Regulation Of MAPK Cascade Epidermal Growth Factor Receptor Signaling Pathway Protein Kinase Activity Tissue Morphogenesis Regulation Of Apoptotic Process Morphogenesis Of An Epithelium Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade ERBB Signaling Pathway Peptidyl-tyrosine Phosphorylation Positive Regulation Of Intracellular Signal Transduction Kinase Activity ERBB2 Signaling Pathway Intermediate Filament Cellular Developmental Process Basal Plasma Membrane Positive Regulation Of Signal Transduction Protein Autophosphorylation Cell Surface Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Positive Regulation Of Epithelial Cell Proliferation Regulation Of Signal Transduction Negative Regulation Of Programmed Cell Death Response To Growth Factor ERBB3:ERBB2 Complex Protein Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cell Differentiation Protein Phosphatase Binding Growth Factor Binding Myelination Anatomical Structure Morphogenesis Regulation Of Extrinsic Apoptotic Signaling Pathway Axon Ensheathment Neuron Differentiation System Development	Negative Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition RNA Polymerase III Assembly RNA Polymerase I Assembly Negative Regulation Of Cell Cycle Process Glial Cytoplasmic Inclusion Classical Lewy Body Negative Regulation Of Cell Cycle Phase Transition Lewy Body Corona Negative Regulation Of Mitotic Cell Cycle Lewy Neurite Regulation Of Mitotic Cell Cycle Phase Transition RNA Polymerase II Core Complex Assembly Negative Regulation Of Cell Cycle Chylomicron Assembly Lewy Body Core Negative Regulation Of Defense Response To Bacterium Regulation Of Cell Cycle Phase Transition
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