SHC3 and ZMYND12

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SHC3	ZMYND12
Description		SHC adaptor protein 3	zinc finger MYND-type containing 12
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane	Cilium Motile Cilium Sperm Flagellum Cell Projection
	Molecular Function	Phosphotyrosine Residue Binding Protein Binding Receptor Tyrosine Kinase Binding	Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Central Nervous System Development Intracellular Signal Transduction	Sperm Axoneme Assembly Flagellated Sperm Motility
Pathways		Signalling to RAS Signalling to RAS RAF/MAP kinase cascade RET signaling
Drugs
Diseases
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847) Logical memory (delayed recall) in Alzheimer's disease dementia ( 29274321) Monocyte count ( 32888494) Pelvic organ prolapse (moderate/severe) ( 26545240) Response to statins (LDL cholesterol change) ( 22331829) Superior parietal cortex volume ( 31530798) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)
Interacting Genes		58 interacting genes: ALK ANKRD10 APP AR ARHGAP32 ASPG AXL BMF CCNC CDCA4 CEACAM6 COPS6 CT55 DOK3 EGFR ERBB2 ERBB3 ERBB4 FLT4 FTO GAB1 GOLGA2 GOLGA6L9 GRB2 KIT KRT31 KRT33B KRT34 KRT35 KRT39 KRT40 KRT86 MET NTRK1 NTRK2 PMF1 PNMA1 PPP1R16B PRKAR1B PSMD8 REL RET SH3GL3 SMYD3 STX11 TRAF1 TRAF2 TRIM35 TRIM54 TSC1 UBAP2 USHBP1 USP54 VPS28 WWOX YPEL3 YPEL5 ZMYND12	80 interacting genes: ABI2 AIRIM ARHGAP8 ARMC8 ATOSB BMAL1 CCDC116 CCDC24 CHCHD2 CWF19L2 DMRT3 EVX2 FAM222B FAM50B FAM90A1 GPKOW GSTZ1 HAPLN2 HDAC4 HOXB5 HOXC9 HR HSF4 ILF2 INCA1 KANK2 LENG1 LMO2 LMO4 MAD2L2 MNS1 MOAP1 MSGN1 MSRB3 NAB2 NUDT22 ONECUT3 PATL1 PICK1 POM121 POU6F2 PPP1R18 PRKAA2 PRR35 PRR5-ARHGAP8 PRR5L PSMB8 QARS1 RIPPLY1 RUSC1 SAMD11 SAXO1 SAXO4 SCNM1 SDCBP SEC14L4 SH2D4A SHC3 SMARCD1 SMG9 SOHLH1 SPG21 STRA8 TEKT4 TEKT5 TEPSIN TFAP2D THOC1 THRSP TLE5 TSEN54 TSSK3 TTC29 TXN2 TYMP UNC5CL VEZF1 VPS37C ZNF148 ZNF414
Entrez ID		53358	84217
HPRD ID		12005	15740
Ensembl ID		ENSG00000148082	ENSG00000066185
Uniprot IDs		Q92529	B4DX70 Q9H0C1
PDB IDs			8J07
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Activity Receptor Complex Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Structural Constituent Of Skin Epidermis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Programmed Cell Death Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Positive Regulation Of MAPK Cascade Epidermal Growth Factor Receptor Signaling Pathway Protein Kinase Activity Tissue Morphogenesis Regulation Of Apoptotic Process Morphogenesis Of An Epithelium Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade ERBB Signaling Pathway Peptidyl-tyrosine Phosphorylation Positive Regulation Of Intracellular Signal Transduction Kinase Activity ERBB2 Signaling Pathway Intermediate Filament Cellular Developmental Process Basal Plasma Membrane Positive Regulation Of Signal Transduction Protein Autophosphorylation Cell Surface Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Positive Regulation Of Epithelial Cell Proliferation Regulation Of Signal Transduction Negative Regulation Of Programmed Cell Death Response To Growth Factor ERBB3:ERBB2 Complex Protein Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cell Differentiation Protein Phosphatase Binding Growth Factor Binding Myelination Anatomical Structure Morphogenesis Regulation Of Extrinsic Apoptotic Signaling Pathway Axon Ensheathment Neuron Differentiation System Development	Protein Binding Sperm Flagellum Axonemal A Tubule Inner Sheath Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Motile Cilium Regulation Of RNA Metabolic Process Nucleus Chromatin Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Activity Transcription Coregulator Activity
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?