NGLY1 and PROC

		NGLY1	PROC
Description		N-glycanase 1	protein C, inactivator of coagulation factors Va and VIIIa
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Extracellular Region Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen Golgi Apparatus Golgi Lumen
	Molecular Function	Peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine Amidase Activity Protein Binding Hydrolase Activity Metal Ion Binding	Endopeptidase Activity Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity
	Biological Process	Protein Folding Glycoprotein Catabolic Process Positive Regulation Of BMP Signaling Pathway	Proteolysis Blood Coagulation Hemostasis Negative Regulation Of Blood Coagulation Negative Regulation Of Apoptotic Process Negative Regulation Of Inflammatory Response Negative Regulation Of Coagulation Positive Regulation Of Establishment Of Endothelial Barrier
Pathways		N-glycan trimming in the ER and Calnexin/Calreticulin cycle	Intrinsic Pathway of Fibrin Clot Formation Common Pathway of Fibrin Clot Formation Gamma-carboxylation of protein precursors Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Removal of aminoterminal propeptides from gamma-carboxylated proteins Cell surface interactions at the vascular wall Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs			Menadione Sodium tetradecyl sulfate Cupric Chloride Kappadione Protein S human
Diseases			Inherited thrombophilia
GWAS			Blood protein levels ( 30072576) Protein C levels ( 20802025 25376901 28082259)
Interacting Genes		19 interacting genes: APP BICRAL FAF1 GUCD1 NPAS2 NSFL1C PAX5 PAX6 RAD23A RAD23B SRPK2 TCF12 TRAFD1 TRIM54 UBC UBQLN1 UBXN2B VCP VMAC	15 interacting genes: CP CSNK2B CYSRT1 F2 F5 F8 GGCX KLK1 PF4 PROCR PROS1 SERPINA5 SERPINB6 THBD TK1
Entrez ID		55768	5624
HPRD ID		10118	01466
Ensembl ID		ENSG00000151092	ENSG00000115718
Uniprot IDs		Q96IV0	B4DPC8 B4DPQ3 E7END6 P04070
PDB IDs		2CCQ 2CM0	1AUT 1LQV 3F6U 3JTC 4DT7 6M3B 6M3C 8JRU 8JRV 9BVM
Enriched GO Terms of Interacting Partners?		Polyubiquitin Modification-dependent Protein Binding Ubiquitin Binding Modification-dependent Protein Catabolic Process Proteasome Complex VCP-NSFL1C Complex Negative Regulation Of Protein Localization To Centrosome Proteolysis Involved In Protein Catabolic Process Proteasomal Protein Catabolic Process Positive Regulation Of Mitotic Centrosome Separation Positive Regulation Of Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Establishment Of Mitotic Spindle Orientation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Catabolic Process Establishment Of Mitotic Spindle Localization Establishment Of Spindle Orientation Microtubule Cytoskeleton Organization Involved In Mitosis Proteolysis Regulation Of Mitotic Centrosome Separation VCP-NPL4-UFD1 AAA ATPase Complex Establishment Of Spindle Localization Spindle Localization Macromolecule Catabolic Process Positive Regulation Of Cell Cycle HMG Box Domain Binding Regulation Of Protein Localization To Centrosome Positive Regulation Of Proteolysis Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Protein Localization Proteasome Binding Ubiquitin-specific Protease Binding ERAD Pathway Autophagosome Assembly Autophagosome Organization Negative Regulation Of Hippo Signaling Nuclear Membrane Reassembly Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Viral Genome Replication Response To Stress Microtubule-based Process Ubiquitin Protein Ligase Binding Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Amyloid-beta Complex Growth Cone Lamellipodium Positive Regulation Of Catabolic Process Central Nervous System Development Regulation Of Response To Calcium Ion	Coagulation Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Negative Regulation Of Coagulation Extracellular Space Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Platelet Alpha Granule Lumen Negative Regulation Of Wound Healing Regulation Of Hemostasis Regulation Of Blood Coagulation Extracellular Region Biological Process Involved In Interaction With Symbiont Endoplasmic Reticulum Lumen Regulation Of Wound Healing Copper Ion Binding Regulation Of Response To Wounding Extracellular Exosome Negative Regulation Of Fibrinolysis Golgi Lumen Regulation Of Fibrinolysis Negative Regulation Of Platelet Activation Fibrinolysis Platelet Alpha Granule Protease Binding Protein Activation Cascade Blood Microparticle Protein Maturation Positive Regulation Of Blood Coagulation Regulation Of Biological Quality Positive Regulation Of Coagulation Killing By Host Of Symbiont Cells Heparin Binding Extracellular Matrix Negative Regulation Of Multicellular Organismal Process COPII-coated ER To Golgi Transport Vesicle Zymogen Activation Acute-phase Response Oxidoreductase Activity, Acting On Metal Ions, Oxygen As Acceptor Gamma-glutamyl Carboxylase Activity Protein C Inhibitor-coagulation Factor V Complex Protein C Inhibitor-TMPRSS7 Complex Protein C Inhibitor-PLAU Complex Protein C Inhibitor-TMPRSS11E Complex Protein C Inhibitor-coagulation Factor Xa Complex Protein C Inhibitor-KLK3 Complex Protein C Inhibitor-plasma Kallikrein Complex Protein C Inhibitor-thrombin Complex Protein C Inhibitor-coagulation Factor XI Complex
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