H2AJ and PLEKHA5

		H2AJ	PLEKHA5
Description		H2A.J histone	pleckstrin homology domain containing A5
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GO Annotations	Cellular Component	Nucleosome Nucleus Chromosome Extracellular Exosome	Nucleoplasm Cytoplasm Cytosol Postsynaptic Density Membrane Glutamatergic Synapse
	Molecular Function	DNA Binding Structural Constituent Of Chromatin Protein Heterodimerization Activity	Protein Binding Phosphatidylinositol-5-phosphate Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol-4-phosphate Binding Phosphatidylinositol-3,5-bisphosphate Binding
	Biological Process	Heterochromatin Formation	Reproductive System Development
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence RMTs methylate histone arginines SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Deposition of new CENPA-containing nucleosomes at the centromere Assembly of the ORC complex at the origin of replication RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination Transcriptional regulation of granulopoiesis Inhibition of DNA recombination at telomere Defective pyroptosis Negative Regulation of CDH1 Gene Transcription Chromatin modifications during the maternal to zygotic transition (MZT) MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Regulation of PD-L1(CD274) transcription	Synthesis of PIPs at the plasma membrane
Drugs
Diseases
GWAS			Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) Chronic mountain sickness ( 31417607) Daytime sleep phenotypes ( 27126917) Gut microbiota (bacterial taxa) ( 27694959) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Pharmacokinetics of antiepileptic drugs in severe mental disorder (concentration drug ratio) ( 25944848) Platelet reactivity in response to clopidogrel treatment ( 32472697) Thalamus volume ( 31530798)
Interacting Genes			30 interacting genes: ARHGEF9 BLOC1S6 CCDC186 CCDC88B CCDC92 CEP250 CEP350 DES EVPL EXTL3 KANSL1 KIF3A KRT19 KRT20 KTN1 LAMB2 LSM4 MAX MTCL2 PLEC PLEKHA6 PPP1R13B PROM1 SH3BP5L SPTAN1 SPTBN1 SRPK2 UPF1 WASH2P YWHAG
Entrez ID		55766	54477
HPRD ID		13622	09684
Ensembl ID		ENSG00000246705	ENSG00000052126
Uniprot IDs		Q9BTM1	A0A8V8TQ09 A0A8V8TQJ8 A0A9L9PX43 Q9HAU0
PDB IDs		4EDU 6K60 6KVD 7TRF	2DKP
Enriched GO Terms of Interacting Partners?		Reproductive System Development Phosphatidylinositol-4-phosphate Binding Phosphatidylinositol-3,5-bisphosphate Binding Phosphatidylinositol-5-phosphate Binding Phosphatidylinositol-3-phosphate Binding Postsynaptic Density	Structural Constituent Of Cytoskeleton Cytoskeleton Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Organelle Organization Intermediate Filament Cytoskeleton Cytoskeleton Organization Double-stranded DNA Helicase Activity Intermediate Filament Organization Intermediate Filament Cadherin Binding Supramolecular Fiber Organization Extracellular Exosome Spectrin Vesicle Cytoskeletal Trafficking Contractile Muscle Fiber Centriole-centriole Cohesion Centriole Cytoskeletal Protein Binding Costamere Structural Molecule Activity Intracellular Protein Localization Ankyrin Binding Cytoskeleton-dependent Intracellular Transport Actin Cytoskeleton Organization Actin Filament Binding Purine Nucleoside Metabolic Process Epithelial Cell Differentiation Microtubule Anchoring Protein Localization To Centrosome Establishment Of Vesicle Localization Actin Filament-based Process Cytosol DATP Biosynthetic Process Adenosine Kinase Activity Membrane Organization Sarcolemma Metanephric Glomerular Basement Membrane Development MLL1 Complex Microtubule Binding Cilium Assembly Vesicle Localization Bradykinin Biosynthetic Process Circadian Sleep/wake Cycle Actin Filament Capping Establishment Of Organelle Localization Regulation Of Protein-containing Complex Disassembly
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