FERMT1

Description		FERM domain containing kindlin 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Membrane Cell Junction Ruffle Membrane Cell Projection Anchoring Junction Cell Periphery
	Molecular Function	Integrin Binding Actin Filament Binding
	Biological Process	Positive Regulation Of Cell-matrix Adhesion Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Negative Regulation Of Gene Expression Positive Regulation Of Cell Migration Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Integrin Activation Positive Regulation Of Cell Adhesion Mediated By Integrin Negative Regulation Of Protein Import Into Nucleus Keratinocyte Proliferation Keratinocyte Migration Negative Regulation Of Timing Of Anagen Positive Regulation Of Transforming Growth Factor Beta Production Basement Membrane Organization Negative Regulation Of Canonical Wnt Signaling Pathway Establishment Of Epithelial Cell Polarity Positive Regulation Of Wound Healing, Spreading Of Epidermal Cells Negative Regulation Of Stem Cell Proliferation
Pathways
Drugs
Diseases		Kindler syndrome
GWAS		Abdominal aortic aneurysm ( 27899403) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Lung function (low FEV1 vs high FEV1) ( 26423011) Retinal detachment or retinal break ( 31816047) Smooth-surface caries ( 24556642) Triglyceride levels x loop diuretics use interaction ( 31806883)
Interacting Genes		4 interacting genes: ILK ITGB1 PARVA SRPK1
Entrez ID		55612
HPRD ID		06388
Ensembl ID		ENSG00000101311
Uniprot IDs		Q49AC8 Q54A15 Q9BQL6
PDB IDs
Enriched GO Terms of Interacting Partners?		Cell-substrate Adhesion Magnesium Ion Binding Heterotypic Cell-cell Adhesion Anchoring Junction Focal Adhesion Substrate Adhesion-dependent Cell Spreading Cell-cell Adhesion Regulation Of Neural Precursor Cell Proliferation Integrin Binding Cell-matrix Adhesion Neural Precursor Cell Proliferation Cellular Component Assembly Microtubule Cytoskeleton Organization Involved In Mitosis Integrin-mediated Signaling Pathway Myoblast Fate Specification Integrin Alpha6-beta1 Complex Positive Regulation Of Glutamate Uptake Involved In Transmission Of Nerve Impulse Integrin Alpha8-beta1 Complex Integrin Alpha1-beta1 Complex Integrin Alpha5-beta1 Complex Integrin Alpha10-beta1 Complex Integrin Alpha7-beta1 Complex Integrin Alphav-beta1 Complex Integrin Alpha11-beta1 Complex Cardiac Cell Fate Specification Integrin Alpha3-beta1 Complex Integrin Alpha9-beta1 Complex Smooth Muscle Cell Chemotaxis Cell Adhesion Establishment Or Maintenance Of Cell Polarity Cell Migration Protein Localization To Cell Cortex Cytoskeleton Organization Cell Morphogenesis Lamellipodium Integrin Alpha4-beta1 Complex Integrin Alpha2-beta1 Complex Cell Motility Positive Regulation Of L-glutamate Import Across Plasma Membrane Regulation Of Glutamate Uptake Involved In Transmission Of Nerve Impulse Calcium-independent Cell-matrix Adhesion Regulation Of Collagen Catabolic Process Formation Of Radial Glial Scaffolds Establishment Or Maintenance Of Cell Polarity Regulating Cell Shape Cell Projection Organization C-X3-C Chemokine Binding Integrin Binding Involved In Cell-matrix Adhesion Myelin Sheath Abaxonal Region Collagen Binding Involved In Cell-matrix Adhesion Regulation Of Spontaneous Synaptic Transmission
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