GP1BB and TGFB1I1

Number of citations of the paper that reports this interaction (PubMedID 20946164)
0

Data Source:
BioGRID (pull down, affinity chromatography technology)

		GP1BB	TGFB1I1
Description		glycoprotein Ib platelet subunit beta	transforming growth factor beta 1 induced transcript 1
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Glycoprotein Ib-IX-V Complex	Nucleus Cytoplasm Cytosol Cytoskeleton Focal Adhesion Nuclear Matrix Extracellular Matrix Anchoring Junction
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Identical Protein Binding	Transcription Coactivator Activity Protein Binding Metal Ion Binding Roundabout Binding Nuclear Androgen Receptor Binding I-SMAD Binding
	Biological Process	Cell Adhesion Cell Surface Receptor Signaling Pathway Blood Coagulation Blood Coagulation, Intrinsic Pathway Hemostasis Positive Regulation Of Platelet Activation Platelet Activation Megakaryocyte Development Release Of Sequestered Calcium Ion Into Cytosol	Cell Adhesion Negative Regulation Of Cell Population Proliferation Positive Regulation Of Epithelial To Mesenchymal Transition Wnt Signaling Pathway Morphogenesis Of Embryonic Epithelium Cell Differentiation Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Epithelial Cell Differentiation Cell Fate Commitment Fat Cell Differentiation Negative Regulation Of Fat Cell Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways		Intrinsic Pathway of Fibrin Clot Formation GP1b-IX-V activation signalling Platelet Adhesion to exposed collagen Platelet Aggregation (Plug Formation) Defective F9 activation Enhanced binding of GP1BA variant to VWF multimer:collagen Defective binding of VWF variant to GPIb:IX:V
Drugs
Diseases		Bernard-Soulier syndrome; Giant platelet syndrome
GWAS		DNA methylation (parent-of-origin) ( 23725790) Mean platelet volume ( 27863252 32888494) Platelet count ( 27863252 32888494) Platelet distribution width ( 27863252 32888494)	Metabolite levels ( 23823483)
Interacting Genes		4 interacting genes: GP9 PRKACA TGFB1I1 YWHAZ	33 interacting genes: AR CBLB CBLC CDKN2B CRKL CSK EP300 FKBP1A GIT1 GIT2 GP1BB HIPK3 HOXA1 HSPB1 ITCH ITGA4 MAPK15 NEDD4 NEDD4L NR3C1 PLA2G3 PTK2 PTK2B PTPN12 SDC4 SLC6A3 SMAD7 SVIL TGFBR2 TRAF4 UBQLN4 VCL YAP1
Entrez ID		2812	7041
HPRD ID		00729	03831
Ensembl ID		ENSG00000203618	ENSG00000140682
Uniprot IDs		P13224	O43294
PDB IDs		3REZ 3RFE 8WFS
Enriched GO Terms of Interacting Partners?		Negative Regulation Of TOR Signaling TOR Signaling Negative Regulation Of TORC1 Signaling Regulation Of TORC1 Signaling TORC1 Signaling Regulation Of Sequestering Of Calcium Ion Tube Formation Synaptic Target Recognition Inner Ear Auditory Receptor Cell Differentiation Hair Cell Differentiation Positive Regulation Of Signal Transduction Regulation Of Cell Communication Inner Ear Receptor Cell Differentiation Regulation Of Signal Transduction Mechanoreceptor Differentiation Positive Regulation Of Immune Response To Tumor Cell Cellular Developmental Process Pyroptotic Cell Death Wide Pore Channel Activity Granzyme-mediated Programmed Cell Death Signaling Pathway Cardiolipin Binding Epithelial Cell Differentiation Regulation Of Signaling Developmental Process System Process Protein Activation Cascade Glycoprotein Ib-IX-V Complex Blood Coagulation, Intrinsic Pathway Positive Regulation Of Platelet Activation Megakaryocyte Development Regulation Of Body Fluid Levels CAMP-dependent Protein Kinase Complex Protein-lipid Complex Assembly Vascular Endothelial Cell Response To Fluid Shear Stress Response To Nutrient Levels Cellular Response To Parathyroid Hormone Stimulus Negative Regulation Of Glycolytic Process Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Cellular Response To Glucagon Stimulus Ubiquitin Protein Ligase Binding Negative Regulation Of Interleukin-2 Production Response To Laminar Fluid Shear Stress Sperm Capacitation Protein Domain Specific Binding CAMP-dependent Protein Kinase Activity Interleukin-2-mediated Signaling Pathway Protein Phosphorylation Calcium Channel Complex Regulation Of Proteolysis Cellular Response To Laminar Fluid Shear Stress	Regulation Of Cellular Component Organization Cell Surface Receptor Signaling Pathway Developmental Process Focal Adhesion Regulation Of Signal Transduction Regulation Of Cell Adhesion Regulation Of Cell Communication Regulation Of Signaling Regulation Of Intracellular Signal Transduction Anchoring Junction Regulation Of Multicellular Organismal Process Response To Growth Factor Negative Regulation Of Signal Transduction Cell Activation Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Cell-cell Adhesion Regulation Of CD4-positive, Alpha-beta T Cell Activation Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of T Cell Tolerance Induction Type I Transforming Growth Factor Beta Receptor Binding Cellular Response To Growth Factor Stimulus Leukocyte Activation Positive Regulation Of Tolerance Induction Regulation Of Cell Population Proliferation Signal Transduction Positive Regulation Of Multicellular Organismal Process Regulation Of T Cell Tolerance Induction Anatomical Structure Morphogenesis Transferase Activity Costamere Negative Regulation Of Cell-cell Adhesion Regulation Of Protein Metabolic Process Enzyme-linked Receptor Protein Signaling Pathway Intracellular Signal Transduction Regulation Of Alpha-beta T Cell Activation Positive Regulation Of Cell Adhesion Plasma Membrane Proline-rich Region Binding Cytosol Regulation Of Immune System Process Regulation Of Tolerance Induction Negative Regulation Of T Cell Activation Developmental Growth Protein Modification Process Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Regulation Of T Cell Activation Positive Regulation Of Catabolic Process Regulation Of Apoptotic Process Tissue Morphogenesis
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