NHP2 and NOS1AP

Number of citations of the paper that reports this interaction (PubMedID 25814554)
62

Data Source:
BioGRID (two hybrid)

		NHP2	NOS1AP
Description		NHP2 ribonucleoprotein	nitric oxide synthase 1 adaptor protein
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Telomerase Holoenzyme Complex Nucleolus Sno(s)RNA-containing Ribonucleoprotein Complex Cajal Body Box H/ACA SnoRNP Complex Box H/ACA ScaRNP Complex Box H/ACA Telomerase RNP Complex Ribonucleoprotein Complex	Podosome Nucleus Mitochondrion Cytosol Caveola Z Disc Filopodium T-tubule Nuclear Membrane Sarcoplasmic Reticulum Membrane Sarcolemma Cell Projection Perinuclear Region Of Cytoplasm Anchoring Junction Glutamatergic Synapse
	Molecular Function	RNA Binding MRNA 3'-UTR Binding Protein Binding U3 SnoRNA Binding Box H/ACA SnoRNA Binding Telomerase RNA Binding	Protein Binding Nitric-oxide Synthase Regulator Activity Signaling Adaptor Activity Nitric-oxide Synthase Binding
	Biological Process	SnoRNA Guided RRNA Pseudouridine Synthesis RRNA Processing Telomere Maintenance Via Telomerase RRNA Pseudouridine Synthesis SnRNA Pseudouridine Synthesis Ribosome Biogenesis Telomerase RNA Localization To Cajal Body	Regulation Of Heart Rate By Chemical Signal Nitric Oxide Biosynthetic Process Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Regulation Of Cardiac Muscle Cell Action Potential Postsynaptic Actin Cytoskeleton Organization Positive Regulation Of Potassium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Positive Regulation Of Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential
Pathways		Telomere Extension By Telomerase rRNA modification in the nucleus and cytosol
Drugs
Diseases		Dyskeratosis congenita (DC), including: X-linked dyskeratosis congenita (DKCX); Autosomal dominant dyskeratosis congenita (DKCA1); Autosomal recessive dyskeratosis congenita (DKCB1)
GWAS		Platelet count ( 29403010)	Alanine aminotransferase levels in non-alcoholic fatty liver disease ( 31311600) Body mass index (change over time) ( 25133637) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits ( 20062061 20062063 25055868) Electrocardiographic traits (multivariate) ( 32602732) Granulocyte percentage of myeloid white cells ( 27863252) Heel bone mineral density ( 30598549) Iris color (L* coordinate) ( 30895295) Lateral ventricle temporal horn volume ( 31530798) Long QT syndrome ( 32429735) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494 27863252) Mosquito bite size ( 28199695) Obesity-related traits ( 23251661) QT interval ( 19305408 19305409 19587794 30679814 16648850 29874175 29213071 20031603 22726844 23166209 24952745) Sum of carotid plaque area ( 32469969) Sum of stenosis ( 32469969) T wave morphology restitution during exercise ( 31607149) T wave morphology restitution during exercise (MTAG) ( 31607149) T wave morphology restitution during recovery from exercise ( 31607149) T wave morphology restitution during recovery from exercise (MTAG) ( 31607149) Word reading ( 23738518)
Interacting Genes		10 interacting genes: IKBKG JMJD6 MYL2 NEDD4 NEDD4L NOS1AP PRNP RSPH1 UBE2I UTP23	18 interacting genes: AKNAD1 APP CKM FYN HSPD1 LRP1 LRP2 LRP8 NHP2 NOS1 PLAGL2 PNP RASD1 RYBP SYN1 SYN2 SYN3 TRAF4
Entrez ID		55651	9722
HPRD ID		07570	12023
Ensembl ID		ENSG00000145912	ENSG00000198929
Uniprot IDs		J3QSY4 Q9NX24	O75052
PDB IDs		7BGB 7TRC 7V9A 8OUE 8OUF
Enriched GO Terms of Interacting Partners?		Regulation Of Potassium Ion Transmembrane Transport Regulation Of Potassium Ion Transport Negative Regulation Of Potassium Ion Export Across Plasma Membrane Sodium Channel Inhibitor Activity Regulation Of Monoatomic Cation Transmembrane Transport Potassium Channel Inhibitor Activity Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Potassium Ion Export Across Plasma Membrane Negative Regulation Of Sodium Ion Transport Regulation Of Metal Ion Transport Transmembrane Transporter Binding Receptor Catabolic Process Regulation Of Monoatomic Ion Transport Negative Regulation Of Potassium Ion Transmembrane Transport Postsynaptic Cytosol Negative Regulation Of Potassium Ion Transport Cytosol Neuromuscular Junction Development Regulation Of Membrane Repolarization Receptor Metabolic Process Regulation Of T Cell Receptor Signaling Pathway Muscle Cell Fate Specification Regulation Of Dendrite Morphogenesis Regulation Of Synapse Organization Protein Monoubiquitination Formation Of Structure Involved In A Symbiotic Process Type 8 Metabotropic Glutamate Receptor Binding SUMO Conjugating Enzyme Activity Histone H4R3 Demethylase Activity Peptidyl-lysine Hydroxylation To 5-hydroxy-L-lysine Peptidyl-lysine 5-dioxygenase Activity Histone H3R2 Demethylase Activity Oxidative RNA Demethylation Receptor Internalization Negative Regulation Of Cation Transmembrane Transport Regulation Of Sodium Ion Transport Negative Regulation Of Monoatomic Ion Transmembrane Transport Cellular Component Assembly Signaling Adaptor Activity Channel Inhibitor Activity Ubiquitin Ligase Complex Regulation Of Membrane Potential Phosphothreonine Residue Binding Negative Regulation Of Monoatomic Ion Transport Regulation Of Dendrite Development RING-like Zinc Finger Domain Binding Linear Polyubiquitin Binding Positive Regulation Of Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Positive Regulation Of Membrane Repolarization During Cardiac Muscle Cell Action Potential Negative Regulation Of Protein Homooligomerization	Apolipoprotein Binding Synaptic Vesicle Cycle Synaptic Vesicle Clustering Low-density Lipoprotein Particle Receptor Activity Clathrin-coated Pit Synaptic Signaling Cargo Receptor Activity Schaffer Collateral - CA1 Synapse Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Astrocyte Activation Involved In Immune Response Postsynaptic Density Cellular Response To Growth Factor Stimulus Growth Factor Receptor Binding Positive Regulation Of Lysosomal Protein Catabolic Process Neurotransmitter Secretion Chemical Synaptic Transmission Response To Growth Factor Trans-synaptic Signaling Cellular Response To Amyloid-beta Positive Regulation Of Protein Catabolic Process In The Vacuole Cell-cell Signaling Regulation Of Protein Catabolic Process Signaling Response To Amyloid-beta Cell Communication Receptor Complex High-density Lipoprotein Particle Binding Regulation Of Lysosomal Protein Catabolic Process Retinoid Metabolic Process Reelin-mediated Signaling Pathway Diterpenoid Metabolic Process Cell Body Regulation Of Dendritic Spine Maintenance Calcium-dependent Protein Binding Dendrite Extrinsic Component Of Synaptic Vesicle Membrane Vesicle-mediated Transport Modulation Of Chemical Synaptic Transmission Synapse Organization Terpenoid Metabolic Process Vesicle-mediated Transport In Synapse Protein-folding Chaperone Binding Heparan Sulfate Proteoglycan Binding Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Neuron Projection Morphogenesis Astrocyte Activation Layer Formation In Cerebral Cortex Isoprenoid Metabolic Process Neurotransmitter Transport
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