TRMT1 and TNPO2

Data Source: HiPPIP (Novel)

		TRMT1	TNPO2
Name		tRNA methyltransferase 1	transportin 2
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion	Nucleus Cytoplasm
	Molecular Function	TRNA Binding RNA Binding Protein Binding Methyltransferase Activity Zinc Ion Binding TRNA (guanine) Methyltransferase Activity Transferase Activity Metal Ion Binding TRNA (guanine(26)-N2)-dimethyltransferase Activity	Protein Binding Nuclear Localization Sequence Binding Small GTPase Binding Nuclear Import Signal Receptor Activity
	Biological Process	TRNA N2-guanine Methylation TRNA Modification TRNA Processing Methylation	Protein Import Into Nucleus Intracellular Protein Transport Protein Transport Negative Regulation Of Muscle Cell Differentiation
Pathways		tRNA modification in the nucleus and cytosol	None
GWAS		Brain morphology (MOSTest) ( 32665545 ) Lymphocyte percentage of white cells ( 27863252 ) Mean platelet volume ( 32888494 ) Neutrophil percentage of white cells ( 27863252 ) Reticulocyte fraction of red cells ( 32888494 )	Diffuse large B-cell lymphoma or multiple sclerosis ( 31407831 )
Interacting Genes		3 interacting genes: CFTR MAGEA11 TERF1	54 interacting genes: A1CF APIP BEND7 BIRC7 BIRC8 BLMH C1orf94 CAMK2B CAMK2D CAMK2G CCDC158 CEBPA CRYAB CTAG1A CTAG1B ELAVL1 EXOC5 FH FTO FUCA2 GCH1 GSC2 KLHL2 KLHL20 KLHL3 KRT75 KRTAP8-1 NME1 NUP98 NXF1 OTX2 PACSIN3 PDLIM7 PIK3CD PINX1 PNMA5 POU6F2 PRMT8 PYCR1 RBM45 REDIC1 RIPK4 RNF10 RPL4 RPRD1B SERTAD3 SF1 TBX2 TCL1B TERF1 THAP6 TRIM8 ZBTB32 ZC2HC1C
Entrez ID		55621	30000
HPRD ID		08617	04301
Ensembl ID		ENSG00000104907	ENSG00000105576
Uniprot IDs		Q9NXH9	O14787 Q05D48
PDB IDs		9DW6	Not available
GO Terms Enriched among Interactors		Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly S-methyl-5-thioribose-1-phosphate Isomerase Activity Positive Regulation Of Anion Channel Activity Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Positive Regulation Of Monoatomic Anion Transport Positive Regulation Of Enamel Mineralization Isomerase Activity Fibrillar Center Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Transepithelial Water Transport Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Regulation Of Establishment Of Protein Localization To Chromosome Regulation Of Establishment Of Protein Localization To Telomere Telomerase Activity Shelterin Complex Meiotic Telomere Clustering Ankyrin Repeat Binding Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation Protein Localization To Perinuclear Region Of Cytoplasm FHF Complex L-methionine Salvage L-methionine Salvage From Methylthioadenosine Amelogenesis Nuclear Telomere Cap Complex Telomere Localization Telomeric D-loop Disassembly Double-stranded Telomeric DNA Binding ATPase-coupled Inorganic Anion Transmembrane Transporter Activity G-rich Strand Telomeric DNA Binding Telomeric Loop Disassembly Microtubule Binding T-circle Formation Telomere Capping Methionine Biosynthetic Process Regulation Of Monoatomic Anion Transport Epithelial Fluid Transport Golgi-associated Vesicle Membrane HOPS Complex	Identical Protein Binding Calcium- And Calmodulin-dependent Protein Kinase Complex Protein Binding Calcium/calmodulin-dependent Protein Kinase Activity Protein Homodimerization Activity