TRMT1 and MRI1

Data Source: HiPPIP (Novel)

		TRMT1	MRI1
Name		tRNA methyltransferase 1	methylthioribose-1-phosphate isomerase 1
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion	Fibrillar Center Nucleus Nucleoplasm Cytoplasm Cytosol Cell Projection
	Molecular Function	TRNA Binding RNA Binding Protein Binding Methyltransferase Activity Zinc Ion Binding TRNA (guanine) Methyltransferase Activity Transferase Activity Metal Ion Binding TRNA (guanine(26)-N2)-dimethyltransferase Activity	Protein Binding Isomerase Activity Identical Protein Binding S-methyl-5-thioribose-1-phosphate Isomerase Activity
	Biological Process	TRNA N2-guanine Methylation TRNA Modification TRNA Processing Methylation	Amino Acid Biosynthetic Process Methionine Biosynthetic Process L-methionine Salvage From Methylthioadenosine
Pathways		tRNA modification in the nucleus and cytosol	Methionine salvage pathway
GWAS		Brain morphology (MOSTest) ( 32665545 ) Lymphocyte percentage of white cells ( 27863252 ) Mean platelet volume ( 32888494 ) Neutrophil percentage of white cells ( 27863252 ) Reticulocyte fraction of red cells ( 32888494 )	Brain morphology (MOSTest) ( 32665545 )
Interacting Genes		3 interacting genes: CFTR MAGEA11 TERF1	4 interacting genes: ATF7IP COG6 PICK1 PLEKHF2
Entrez ID		55621	84245
HPRD ID		08617	14548
Ensembl ID		ENSG00000104907	ENSG00000037757
Uniprot IDs		Q9NXH9	Q9BV20
PDB IDs		9DW6	4LDQ 4LDR
GO Terms Enriched among Interactors		Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly S-methyl-5-thioribose-1-phosphate Isomerase Activity Positive Regulation Of Anion Channel Activity Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Positive Regulation Of Monoatomic Anion Transport Positive Regulation Of Enamel Mineralization Isomerase Activity Fibrillar Center Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Transepithelial Water Transport Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Regulation Of Establishment Of Protein Localization To Chromosome Regulation Of Establishment Of Protein Localization To Telomere Telomerase Activity Shelterin Complex Meiotic Telomere Clustering Ankyrin Repeat Binding Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation Protein Localization To Perinuclear Region Of Cytoplasm FHF Complex L-methionine Salvage L-methionine Salvage From Methylthioadenosine Amelogenesis Nuclear Telomere Cap Complex Telomere Localization Telomeric D-loop Disassembly Double-stranded Telomeric DNA Binding ATPase-coupled Inorganic Anion Transmembrane Transporter Activity G-rich Strand Telomeric DNA Binding Telomeric Loop Disassembly Microtubule Binding T-circle Formation Telomere Capping Methionine Biosynthetic Process Regulation Of Monoatomic Anion Transport Epithelial Fluid Transport Golgi-associated Vesicle Membrane HOPS Complex	Trans-Golgi Network Membrane TRNA N2-guanine Methylation TRNA (guanine(26)-N2)-dimethyltransferase Activity