CDC42BPG and RHOQ

Number of citations of the paper that reports this interaction (PubMedID 15194684)
0

Data Source:
BioGRID (pull down)

		CDC42BPG	RHOQ
Description		CDC42 binding protein kinase gamma	ras homolog family member Q
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Cell Leading Edge Centriolar Satellite	Cytoplasm Actin Filament Plasma Membrane Membrane Golgi-associated Vesicle Membrane Membrane Raft Extracellular Exosome
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity	Nucleotide Binding GTPase Activity Protein Binding Profilin Binding GTP Binding Protein Kinase Binding GBD Domain Binding
	Biological Process	Protein Phosphorylation Actin Cytoskeleton Organization Actomyosin Structure Organization	Endocytosis Actin Filament Organization Signal Transduction Small GTPase-mediated Signal Transduction Insulin Receptor Signaling Pathway Regulation Of Cell Shape Establishment Of Cell Polarity Actin Cytoskeleton Organization Cortical Actin Cytoskeleton Organization Cellular Response To Insulin Stimulus Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Transcription By RNA Polymerase II GTP Metabolic Process Positive Regulation Of D-glucose Import Positive Regulation Of Filopodium Assembly Negative Regulation Of Protein Localization To Plasma Membrane
Pathways			Translocation of SLC2A4 (GLUT4) to the plasma membrane RHO GTPases regulate CFTR trafficking RHOQ GTPase cycle
Drugs		Fostamatinib
Diseases
GWAS		Gout (combined type) ( 32238385) Serum metabolite levels ( 33031748) Serum uric acid levels ( 29124443) Urate levels ( 21768215)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		4 interacting genes: CDC42 RAC1 RHOQ TBK1	22 interacting genes: BANP CDC42BPG CDC42EP1 CDC42EP2 CDC42EP3 CDC42EP4 COPB1 COPG1 DOCK8 EXOC7 GOPC MORN4 NTAQ1 PARD6A PARD6B PFN1 PRKCI RAPGEF1 TRIP10 TRIP6 WASL ZNF417
Entrez ID		55561	23433
HPRD ID		13013	05791
Ensembl ID		ENSG00000171219	ENSG00000119729
Uniprot IDs		Q6DT37	P17081 V9HWD0
PDB IDs			2ATX
Enriched GO Terms of Interacting Partners?		GBD Domain Binding G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Thioesterase Binding Establishment Or Maintenance Of Cell Polarity Regulation Of Cell Projection Assembly GTP-dependent Protein Binding Intracellular Signaling Cassette Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Lamellipodium Assembly Actin Filament Organization Small GTPase-mediated Signal Transduction Positive Regulation Of Filopodium Assembly Phagocytosis, Engulfment Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Lamellipodium Organization GTPase Activity Regulation Of Actin Cytoskeleton Organization GTP Binding Regulation Of Lamellipodium Assembly Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Actin Cytoskeleton Organization Positive Regulation Of Cell Projection Organization Regulation Of Actin Filament-based Process Regulation Of Filopodium Assembly Membrane Invagination Cortical Cytoskeleton Organization Actin Filament-based Process Regulation Of Lamellipodium Organization Non-canonical Wnt Signaling Pathway Positive Regulation Of Stress Fiber Assembly Endocytosis Protein Kinase Binding Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Actin Filament Bundle Assembly Supramolecular Fiber Organization Nucleotide Binding G Protein Activity Positive Regulation Of Cellular Component Biogenesis Regulation Of Cytoskeleton Organization Intracellular Signal Transduction Cytoplasmic Ribonucleoprotein Granule Actin Filament Establishment Of Cell Polarity Import Into Cell Cell Surface Receptor Signaling Pathway Regulation Of Stress Fiber Assembly Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization	Positive Regulation Of Pseudopodium Assembly Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Positive Regulation Of Cell Projection Organization Cytoplasm PAR Polarity Complex Positive Regulation Of Protein Polymerization Cytosol Regulation Of Cell Projection Assembly Regulation Of Actin Filament Polymerization Regulation Of Plasma Membrane Bounded Cell Projection Organization Small GTPase-mediated Signal Transduction Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Cell Projection Organization Small GTPase Binding Rho Protein Signal Transduction Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Protein-containing Complex Assembly Cytoskeleton Tight Junction Regulation Of Cellular Component Size Regulation Of Actin Filament Organization Regulation Of Cell Shape Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Cellular Component Biogenesis Establishment Or Maintenance Of Apical/basal Cell Polarity Positive Regulation Of Cellular Component Organization Cell Leading Edge Regulation Of Actin Cytoskeleton Organization Cell Cortex Actin Cytoskeleton Organization Plasma Membrane COPI Vesicle Coat Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Actin Filament-based Process COPI-coated Vesicle Membrane Regulation Of Protein-containing Complex Assembly Regulation Of Cell Morphogenesis Cell Junction Organization Endomembrane System Positive Regulation Of Organelle Organization Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Regulation Of Cytoskeleton Organization Bicellular Tight Junction Membrane Coat Intracellular Signaling Cassette Centriolar Satellite
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