CDCA7L and PRDM14

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CDCA7L	PRDM14
Description		cell division cycle associated 7 like	PR/SET domain 14
Image			No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol	Nucleus Nucleoplasm
	Molecular Function	Protein Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA Binding RNA Binding Protein Binding Methyltransferase Activity Zinc Ion Binding Transferase Activity Chromatin DNA Binding Metal Ion Binding Methyltransferase Regulator Activity Histone Methyltransferase Binding
	Biological Process	Regulation Of DNA-templated Transcription Positive Regulation Of Cell Population Proliferation	Negative Regulation Of Transcription By RNA Polymerase II Cell Morphogenesis Cell Fate Specification Inner Cell Mass Cell Fate Commitment Regulation Of Transcription By RNA Polymerase II Germ Cell Development Embryo Implantation Fibroblast Growth Factor Receptor Signaling Pathway Fertilization Regulation Of Gene Expression Stem Cell Population Maintenance Germ-line Stem Cell Population Maintenance Methylation Epigenetic Regulation Of Gene Expression Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Gene Expression, Epigenetic Homeostasis Of Number Of Cells Within A Tissue Positive Regulation Of Flagellated Sperm Motility Positive Regulation Of Stem Cell Population Maintenance
Pathways			Transcriptional regulation of pluripotent stem cells
Drugs
Diseases
GWAS		Breast cancer ( 29059683) Gamma glutamyl transferase levels ( 33339817) Height ( 20189936) Multiple myeloma ( 26007630 33875642) Multiple myeloma and monoclonal gammopathy ( 26007630) Pre-treatment viral load in HIV-1 infection ( 31219150) Squamous cell lung carcinoma ( 28604730) Urate levels in obese individuals ( 25811787)	Schizophrenia ( 30285260) Testicular germ cell tumor ( 23666240 28604728 28604732)
Interacting Genes		68 interacting genes: ABT1 ANKRD1 ANKRD11 ANKRD23 AVPI1 AXIN1 BAG5 BEND7 BRPF1 BYSL CARD9 CAVIN1 CCDC116 CCDC33 CEP70 CTNNBL1 DAXX DEDD2 DMAP1 EIF4A3 FAM217B FAM9B GOLGA2 GPRASP3 HSF2BP ING5 JADE2 KRTAP10-7 LMO1 MCRS1 MDFI MEOX2 MFAP1 MLH1 MORN3 MRPL28 MYC NDUFB7 NOL12 NOP2 PBX1 PBX2 PICK1 PIH1D1 PIP4K2B PPP1R16A PPP1R16B PRDM14 PRPF31 RRP7A SNRNP48 SSX1 SSX2IP STX11 SUV39H1 TADA2A TFPT TNNI1 TRAF3IP3 TRIM42 UBL4A UTP3 VDR ZGPAT ZNF250 ZNF438 ZNF620 ZNF821	67 interacting genes: ABI2 AKAP9 AQP1 ATPAF2 BAG4 BAHD1 BCAR3 BEX2 CARD10 CASP8 CDCA7L CHEK2 CREB5 DGCR6 DMRT3 DRC4 EED EIF4E2 ENKD1 ERBB2 EZH2 FAM83A GEM GLYCTK GPATCH2L HEXIM2 HOXB5 HOXC8 HSP90AA2P HSPA5 HSPB7 ID3 IDH1 KANK2 LNX1 MIA3 MRPL32 MYPOP PALB2 PATZ1 PAX2 PLEKHF2 PRKAB2 PRPF31 PSMA1 PTPRJ RAD51D RBM10 RCOR3 RUSC1 SAXO4 SCNM1 SNRPC SUZ12 TCAF1 TEAD4 TEKT4 TLE5 TRIM41 TSGA10 TTC32 TXK USP2 WDR25 ZNF250 ZNF587 ZNF835
Entrez ID		55536	63978
HPRD ID		11481	11457
Ensembl ID		ENSG00000164649	ENSG00000147596
Uniprot IDs		A8K8X5 Q96GN5	Q9GZV8
PDB IDs		5YI9 6EMO
Enriched GO Terms of Interacting Partners?		Nucleus RRNA Metabolic Process Nucleoplasm Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Protein Binding RRNA Processing Regulation Of RNA Metabolic Process Histone Acetyltransferase Complex Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Organization RNA Metabolic Process Chromatin Remodeling Chromosome Nucleolus Nucleic Acid Metabolic Process RNA Processing Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Biosynthetic Process Regulation Of DNA Metabolic Process Regulation Of Primary Metabolic Process SnoRNA Localization Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Myosin Phosphatase Regulator Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Apoptotic Signaling Pathway MOZ/MORF Histone Acetyltransferase Complex Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Protein Localization To Nucleolus Spliceosomal Complex Histone H4K5 Acetyltransferase Activity Histone H4K8 Acetyltransferase Activity Histone H4K12 Acetyltransferase Activity Negative Regulation Of RNA Metabolic Process Skeletal System Morphogenesis DNA Binding Positive Regulation Of Biosynthetic Process Protein-RNA Complex Assembly Titin Binding Regulation Of DNA Replication Dorsal/ventral Axis Specification Regulation Of Signal Transduction By P53 Class Mediator Epigenetic Programming In The Zygotic Pronuclei Positive Regulation Of Telomere Maintenance In Response To DNA Damage	Chromatin Silencing Complex Protein Binding Nucleus Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Ubiquitin Protein Ligase Binding Oligodendrocyte Differentiation ESC/E(Z) Complex Facultative Heterochromatin Formation Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Glial Cell Differentiation Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Identical Protein Binding Regulation Of Primary Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Anoikis Pronucleus Sex Chromatin Negative Regulation Of Transcription By RNA Polymerase II
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