PRDM14 and MRPL32

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PRDM14	MRPL32
Description		PR/SET domain 14	mitochondrial ribosomal protein L32
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Mitochondrial Ribosome Mitochondrial Large Ribosomal Subunit Ribosome Large Ribosomal Subunit Ribonucleoprotein Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA Binding RNA Binding Protein Binding Methyltransferase Activity Zinc Ion Binding Transferase Activity Chromatin DNA Binding Metal Ion Binding Methyltransferase Regulator Activity Histone Methyltransferase Binding	RNA Binding Structural Constituent Of Ribosome Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Cell Morphogenesis Cell Fate Specification Inner Cell Mass Cell Fate Commitment Regulation Of Transcription By RNA Polymerase II Germ Cell Development Embryo Implantation Fibroblast Growth Factor Receptor Signaling Pathway Fertilization Regulation Of Gene Expression Stem Cell Population Maintenance Germ-line Stem Cell Population Maintenance Methylation Epigenetic Regulation Of Gene Expression Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Gene Expression, Epigenetic Homeostasis Of Number Of Cells Within A Tissue Positive Regulation Of Flagellated Sperm Motility Positive Regulation Of Stem Cell Population Maintenance	Translation Mitochondrial Translation
Pathways		Transcriptional regulation of pluripotent stem cells	Mitochondrial translation initiation Mitochondrial translation elongation Mitochondrial translation elongation Mitochondrial translation termination Mitochondrial protein degradation Mitochondrial ribosome-associated quality control
Drugs
Diseases
GWAS		Schizophrenia ( 30285260) Testicular germ cell tumor ( 23666240 28604728 28604732)	Brain morphology (MOSTest) ( 32665545) Lung cancer in ever smokers ( 28604730) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		67 interacting genes: ABI2 AKAP9 AQP1 ATPAF2 BAG4 BAHD1 BCAR3 BEX2 CARD10 CASP8 CDCA7L CHEK2 CREB5 DGCR6 DMRT3 DRC4 EED EIF4E2 ENKD1 ERBB2 EZH2 FAM83A GEM GLYCTK GPATCH2L HEXIM2 HOXB5 HOXC8 HSP90AA2P HSPA5 HSPB7 ID3 IDH1 KANK2 LNX1 MIA3 MRPL32 MYPOP PALB2 PATZ1 PAX2 PLEKHF2 PRKAB2 PRPF31 PSMA1 PTPRJ RAD51D RBM10 RCOR3 RUSC1 SAXO4 SCNM1 SNRPC SUZ12 TCAF1 TEAD4 TEKT4 TLE5 TRIM41 TSGA10 TTC32 TXK USP2 WDR25 ZNF250 ZNF587 ZNF835	1 interacting genes: PRDM14
Entrez ID		63978	64983
HPRD ID		11457	14752
Ensembl ID		ENSG00000147596	ENSG00000106591
Uniprot IDs		Q9GZV8	A4D1V4 Q9BYC8
PDB IDs			3J7Y 3J9M 5OOL 5OOM 6I9R 6NU2 6NU3 6VLZ 6VMI 6ZM5 6ZM6 6ZS9 6ZSA 6ZSB 6ZSC 6ZSD 6ZSE 6ZSG 7A5F 7A5G 7A5H 7A5I 7A5J 7A5K 7L08 7L20 7O9K 7O9M 7ODR 7ODS 7ODT 7OF0 7OF2 7OF3 7OF4 7OF5 7OF6 7OF7 7OG4 7OI6 7OI7 7OI8 7OI9 7OIA 7OIB 7OIC 7OID 7OIE 7PD3 7PO4 7QH6 7QH7 7QI4 7QI5 7QI6 8ANY 8K2A 8K2B 8OIR 8OIT 8PK0 8QSJ 8QU1 8QU5 8RRI 8XT0 8XT1 8XT2 8XT3
Enriched GO Terms of Interacting Partners?		Chromatin Silencing Complex Protein Binding Nucleus Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Ubiquitin Protein Ligase Binding Oligodendrocyte Differentiation ESC/E(Z) Complex Facultative Heterochromatin Formation Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Glial Cell Differentiation Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Identical Protein Binding Regulation Of Primary Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Anoikis Pronucleus Sex Chromatin Negative Regulation Of Transcription By RNA Polymerase II	Methyltransferase Regulator Activity Inner Cell Mass Cell Fate Commitment Germ-line Stem Cell Population Maintenance Positive Regulation Of Flagellated Sperm Motility Positive Regulation Of Cilium Movement Regulation Of Flagellated Sperm Motility Histone Methyltransferase Binding Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Cilium Movement Homeostasis Of Number Of Cells Within A Tissue Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Embryo Implantation Positive Regulation Of Stem Cell Population Maintenance Regulation Of Microtubule-based Movement Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Stem Cell Population Maintenance Positive Regulation Of Reproductive Process Cell Fate Specification Chromatin DNA Binding Stem Cell Population Maintenance Maintenance Of Cell Number Negative Regulation Of Cellular Response To Growth Factor Stimulus Fertilization Anatomical Structure Homeostasis Tissue Homeostasis Regulation Of Reproductive Process Negative Regulation Of Gene Expression, Epigenetic Germ Cell Development Methyltransferase Activity Cell Fate Commitment Cell Morphogenesis Homeostasis Of Number Of Cells Methylation Regulation Of Microtubule-based Process Epigenetic Regulation Of Gene Expression
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