FEM1A and PTGER4

Number of citations of the paper that reports this interaction (PMID 16424369)
17

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		FEM1A	PTGER4
Gene Name		fem-1 homolog a (C. elegans)	prostaglandin E receptor 4 (subtype EP4)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm	Plasma Membrane Integral Component Of Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity EP4 Subtype Prostaglandin E2 Receptor Binding	Prostaglandin E Receptor Activity Protein Binding
	Biological Process	Protein Ubiquitination Negative Regulation Of Inflammatory Response Regulation Of Ubiquitin-protein Transferase Activity	Immune Response Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway JNK Cascade Response To Mechanical Stimulus Regulation Of Ossification Response To Lipopolysaccharide Negative Regulation Of Integrin Activation T-helper Cell Differentiation Negative Regulation Of Cytokine Secretion Positive Regulation Of Cytokine Secretion Negative Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Regulation Of Stress Fiber Assembly Bone Development ERK1 And ERK2 Cascade Cellular Response To Mechanical Stimulus Negative Regulation Of Eosinophil Extravasation
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Prostanoid ligand receptors Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding Eicosanoid ligand-binding receptors
Drugs
Diseases
GWAS			Ankylosing spondylitis ( 21743469) Crohn's disease ( 18587394 17684544 22936669 22412388 21102463) Gastric cancer ( 22037551) Inflammatory bowel disease ( 23128233) Multiple sclerosis ( 19525953 21833088 22570697) Ulcerative colitis ( 21297633)
Protein-Protein Interactions		2 interactors: PPM1F PTGER4	1 interactors: FEM1A
Entrez ID		55527	5734
HPRD ID		16888	03350
Ensembl ID		ENSG00000141965	ENSG00000171522
Uniprot IDs		Q9BSK4	A0PJF5 P35408
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Stress Fiber Assembly Negative Regulation Of Eosinophil Extravasation Negative Regulation Of Integrin Activation Negative Regulation Of Eosinophil Migration Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament-based Process Histone Dephosphorylation Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Regulation Of Cytoskeleton Organization Regulation Of Cell Migration Regulation Of Cell Motility Regulation Of Locomotion Regulation Of Cellular Component Movement Regulation Of Integrin Activation Peptidyl-threonine Dephosphorylation ERK1 And ERK2 Cascade Regulation Of Organelle Organization Negative Regulation Of Leukocyte Migration Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Adherens Junction Organization Negative Regulation Of Peptidyl-serine Phosphorylation T-helper Cell Differentiation Negative Regulation Of Cytokine Secretion CD4-positive, Alpha-beta T Cell Differentiation CD4-positive, Alpha-beta T Cell Activation Positive Regulation Of Stress Fiber Assembly Regulation Of Focal Adhesion Assembly Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Cell-matrix Adhesion Cellular Response To Drug Regulation Of Cell Junction Assembly Alpha-beta T Cell Differentiation Alpha-beta T Cell Activation T Cell Activation Involved In Immune Response Cellular Response To Mechanical Stimulus Intracellular Signal Transduction Regulation Of Cellular Component Organization Positive Regulation Of Epithelial Cell Migration JNK Cascade Positive Regulation Of Cytokine Secretion Positive Regulation Of Inflammatory Response Negative Regulation Of Protein Secretion Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Inflammatory Response Positive Regulation Of Chemotaxis Regulation Of Leukocyte Migration Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Stress-activated MAPK Cascade Regulation Of Cell-matrix Adhesion Stress-activated Protein Kinase Signaling Cascade	Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Inflammatory Response Regulation Of Protein Ubiquitination Regulation Of Inflammatory Response
Tagcloud ?			appeared deltadeltact diestrus endometrium ep2 ep4 equine esr1 esr2 estrus glands immunolabeling immunoreactivity immunostaining intense localize mares myometrium pgr pr pregnancy prostaglandin qpcr quantified reproductive stroma tended weak
Tagcloud (Difference) ?			appeared deltadeltact diestrus endometrium ep2 ep4 equine esr1 esr2 estrus glands immunolabeling immunoreactivity immunostaining intense localize mares myometrium pgr pr pregnancy prostaglandin qpcr quantified reproductive stroma tended weak
Tagcloud (Intersection) ?