TMEM176A and HRSP12

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		TMEM176A	HRSP12
Gene Name		transmembrane protein 176A	heat-responsive protein 12
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Integral Component Of Membrane	Nucleus Cytoplasm Mitochondrion Extracellular Vesicular Exosome
	Molecular Function		Endonuclease Activity Deaminase Activity Poly(A) RNA Binding
	Biological Process	Negative Regulation Of Dendritic Cell Differentiation	Regulation Of Translational Termination Nucleic Acid Phosphodiester Bond Hydrolysis
Pathways
Drugs			Benzoic Acid
Diseases
GWAS		Height ( 20881960 23563607)	Obesity-related traits ( 23251661)
Protein-Protein Interactions		4 interactors: HIVEP1 HRSP12 TGM2 VKORC1	9 interactors: COX2 DEAF1 HIVEP1 HPD MDM2 SERPINA5 SPEN TMEM176A TRIB3
Entrez ID		55365	10247
HPRD ID		13635	03924
Ensembl ID		ENSG00000002933	ENSG00000132541
Uniprot IDs		Q96HP8	P52758
PDB IDs			1ONI
Enriched GO Terms of Interacting Partners?		Isopeptide Cross-linking Via N6-(L-isoglutamyl)-L-lysine Salivary Gland Cavitation Vitamin K Metabolic Process Positive Regulation Of Mitochondrial Calcium Ion Concentration Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Regulation Of Translational Termination Peptidyl-glutamic Acid Carboxylation Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Mitochondrial Calcium Ion Homeostasis	Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Fatty Acid Biosynthetic Process Response To Light Stimulus Cellular Response To UV Maintenance Of Blood-brain Barrier Cellular Response To UV-C Cellular Response To Vitamin B1 Regulation Of Fatty Acid Metabolic Process Response To Radiation Cellular Response To Light Stimulus Cellular Response To Organonitrogen Compound Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Response To Vitamin Positive Regulation Of Nucleocytoplasmic Transport Cellular Response To Oxygen Levels Defense Response Regulation Of Fat Cell Differentiation Positive Regulation Of Fibroblast Growth Factor Production Response To UV Regulation Of Lipid Biosynthetic Process Phosphatidylinositol-mediated Signaling Learning Cellular Response To Radiation Positive Regulation Of Cellular Metabolic Process Gamete Generation Traversing Start Control Point Of Mitotic Cell Cycle Negative Regulation Of Synaptic Transmission, Dopaminergic Nicotinamide Metabolic Process Positive Regulation Of Platelet-derived Growth Factor Production Positive Regulation Of Intracellular Protein Transport Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Cell Differentiation Tyrosine Catabolic Process Response To Vitamin B1 Response To Ether Negative Regulation Of Dendritic Cell Differentiation Response To Carbohydrate Positive Regulation Of Brown Fat Cell Differentiation Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis
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