TMEM176A and TMEM176B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TMEM176A	TMEM176B
Description		transmembrane protein 176A	transmembrane protein 176B
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Membrane	Nucleus Membrane Nuclear Membrane
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Negative Regulation Of Dendritic Cell Differentiation	Animal Organ Morphogenesis Cell Differentiation Dendritic Cell Differentiation Negative Regulation Of Dendritic Cell Differentiation
Pathways
Drugs
Diseases
GWAS		Forced expiratory volume in 1 second (occupational environmental exposures interaction) ( 25979521) HDL cholesterol ( 24097068) HDL cholesterol levels ( 28334899) Height ( 20881960 23563607) Metabolite levels ( 23823483) Serum alkaline phosphatase levels ( 33547301) Serum metabolite concentrations in chronic kidney disease ( 29545352) Waist circumference adjusted for body mass index ( 34021172)	Appendicular lean mass ( 33097823) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693)
Interacting Genes		16 interacting genes: CD79A CERS4 GOLM1 HIVEP1 KCNK5 MTIF3 RETREG3 RIDA SCD5 SGPL1 SLC71A2 TGM2 TIMMDC1 TMEM176B TMX2 VKORC1	3 interacting genes: GLP1R SLC22A2 TMEM176A
Entrez ID		55365	28959
HPRD ID		13635	17443
Ensembl ID		ENSG00000002933	ENSG00000106565
Uniprot IDs		A0A090N8H6 Q96HP8	A0A090N7V7 Q3YBM2
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Peptide Dopaminyltransferase Activity Endoplasmic Reticulum Histone Serotonyltransferase Activity Peptide Histaminyltransferase Activity Protein-glutamine Glutaminase Activity Peptide Noradrenalinyltransferase Activity Peptide Serotonyltransferase Activity Histone Dopaminyltransferase Activity Endoplasmic Reticulum Membrane Sphinganine-1-phosphate Aldolase Activity 2-iminopropanoate Deaminase Activity 2-iminobutanoate/2-iminopropanoate Deaminase L-threonine Catabolic Process To Glycine RNA Endonuclease Activity Producing 3'-phosphomonoesters, Hydrolytic Mechanism 2-iminobutanoate Deaminase Activity Vitamin-K-epoxide Reductase (warfarin-insensitive) Activity Protein Deamination L-threonine Catabolic Process Peptidyl-glutamic Acid Carboxylation Oxidoreductase Activity, Acting On CH Or CH2 Groups, Disulfide As Acceptor Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity Palmitoyl-CoA 9-desaturase Activity Acyl-CoA Desaturase Activity Mitochondrial Translational Initiation Bone Development IgM B Cell Receptor Complex Cellular Response To Serotonin Threonine Metabolic Process N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase Activity Stearoyl-CoA 9-desaturase Activity	Response To Psychosocial Stress Glucagon-like Peptide 1 Receptor Activity Glucagon Receptor Activity Acetylcholine Transport Histamine Uptake Pyrimidine Nucleoside Transmembrane Transporter Activity Spermidine Transport Epinephrine Transport Spermidine Transmembrane Transport Putrescine Transport Thiamine Transmembrane Transporter Activity Thiamine Transport Amine Transmembrane Transporter Activity Quaternary Ammonium Group Transmembrane Transporter Activity Spermidine Transmembrane Transporter Activity L-arginine Import Across Plasma Membrane Putrescine Transmembrane Transporter Activity Thiamine Transmembrane Transport Acetylcholine Transmembrane Transporter Activity Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase Activity N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase Activity Post-translational Protein Targeting To Membrane, Translocation Serotonin Uptake Choline Transport Norepinephrine Uptake Prostaglandin Transmembrane Transporter Activity Xenobiotic Transport Across Blood-brain Barrier Toxin Transmembrane Transporter Activity Monoamine Transmembrane Transporter Activity Choline Transmembrane Transporter Activity Norepinephrine Transport Polyamine Transmembrane Transport Histamine Transport L-arginine Transmembrane Transporter Activity Acetylgalactosaminyltransferase Activity Negative Regulation Of Dendritic Cell Differentiation Cellular Response To Glucagon Stimulus Organic Cation Transmembrane Transporter Activity Efflux Transmembrane Transporter Activity L-arginine Transmembrane Transport Amine Transport Catecholamine Uptake Dopamine Uptake Activation Of Adenylate Cyclase Activity Azole Transmembrane Transport Quaternary Ammonium Group Transport Prostaglandin Transport Serotonin Transport Pyrimidine-containing Compound Transmembrane Transport L-amino Acid Transmembrane Transporter Activity
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