NOS3

Description		nitric oxide synthase 3
Image
GO Annotations	Cellular Component	Golgi Membrane Nucleus Cytoplasm Golgi Apparatus Cytosol Cytoskeleton Plasma Membrane Caveola Membrane Endocytic Vesicle Membrane
	Molecular Function	Actin Monomer Binding Nitric-oxide Synthase Activity Protein Binding Calmodulin Binding FMN Binding Superoxide-generating NAD(P)H Oxidase Activity Oxidoreductase Activity Heme Binding Tetrahydrobiopterin Binding Arginine Binding Cadmium Ion Binding Metal Ion Binding Flavin Adenine Dinucleotide Binding NADP Binding Scaffold Protein Binding
	Biological Process	Angiogenesis Ovulation From Ovarian Follicle In Utero Embryonic Development Blood Vessel Remodeling Regulation Of Sodium Ion Transport Regulation Of The Force Of Heart Contraction By Chemical Signal Regulation Of Systemic Arterial Blood Pressure By Endothelin Aortic Valve Morphogenesis Pulmonary Valve Morphogenesis Endocardial Cushion Morphogenesis L-arginine Catabolic Process Nitric Oxide Biosynthetic Process Potassium Ion Transport Calcium Ion Transport Mitochondrion Organization Nitric Oxide Mediated Signal Transduction Blood Circulation Regulation Of Blood Pressure Negative Regulation Of Cell Population Proliferation Response To Heat Response To Hormone Negative Regulation Of Platelet Activation Positive Regulation Of Gene Expression Negative Regulation Of Muscle Hyperplasia Smooth Muscle Hyperplasia Removal Of Superoxide Radicals Lung Development Regulation Of Nervous System Process Lipopolysaccharide-mediated Signaling Pathway Response To Lipopolysaccharide Response To Fluid Shear Stress Vasodilation Negative Regulation Of Potassium Ion Transport Positive Regulation Of Blood Vessel Endothelial Cell Migration Endothelial Cell Migration Cell Redox Homeostasis Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Angiogenesis Negative Regulation Of Blood Pressure Tetrahydrobiopterin Metabolic Process Nitric Oxide Metabolic Process Negative Regulation Of Smooth Muscle Cell Proliferation Homeostasis Of Number Of Cells Within A Tissue Establishment Of Localization In Cell Negative Regulation Of Calcium Ion Transport Ventricular Septum Morphogenesis Negative Regulation Of Biomineral Tissue Development Blood Vessel Diameter Maintenance Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Pathways		ROS and RNS production in phagocytes Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation eNOS activation eNOS activation NOSTRIN mediated eNOS trafficking NOSIP mediated eNOS trafficking Nitric oxide stimulates guanylate cyclase VEGFR2 mediated vascular permeability Extra-nuclear estrogen signaling High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Drugs		Arginine Citrulline Sapropterin Nitric Oxide Miconazole N,N-dimethylarginine L-N(omega)-Nitroarginine-2,4-L-diaminobutyric amide Canavanine 3-Bromo-7-Nitroindazole N-{(4S)-4-Amino-5-[(2-aminoethyl)amino]pentyl}-N'-nitroguanidine N-[3-(aminomethyl)benzyl]acetamidine 1,2,4-Triazole-Carboxamidine L-N(omega)-nitroarginine-(4R)-amino-L-proline amide S,S'-(1,4-Phenylene-Bis(1,2-Ethanediyl))Bis-Isothiourea 7-Nitroindazole S-Ethylisothiourea 2-Aminothiazoline Se-Ethyl-Isoselenourea 2,4-Diamino-6-Phenyl-5,6,7,8,-Tetrahydropteridine N1,N14-Bis((S-Methyl)Isothioureido)Tetradecane Cacodylic acid 7-Nitroindazole-2-Carboxamidine 6-Nitroindazole N(5)-[(hydroxyamino)(imino)methyl]-L-ornithine N(G)-Iminoethylornithine 5,6-Cyclic-Tetrahydropteridine S-Ethyl-N-Phenyl-Isothiourea S,S'-(1,3-Phenylene-Bis(1,2-Ethanediyl))Bis-Isothiourea 6S-5,6,7,8-Tetrahydrobiopterin S-(Dimethylarsenic)Cysteine L-homoarginine S-Isopropyl-Isothiourea Nitroarginine 5-Nitroindazole N-(Chlorophenyl)-N'-hydroxyguanidine (3S,5E)-3-propyl-3,4-dihydrothieno[2,3-f][1,4]oxazepin-5(2H)-imine 5-{4-[(3,5-DIFLUOROBENZYL)AMINO]PHENYL}-6-ETHYLPYRIMIDINE-2,4-DIAMINE ETHYL 4-[(4-METHYLPYRIDIN-2-YL)AMINO]PIPERIDINE-1-CARBOXYLATE N-{(3S,4S)-4-[(6-AMINO-4-METHYLPYRIDIN-2-YL)METHYL]PYRROLIDIN-3-YL}-N'-(4-CHLOROBENZYL)ETHANE-1,2-DIAMINE N-{(3R,4S)-4-[(6-amino-4-methylpyridin-2-yl)methyl]pyrrolidin-3-yl}-N'-(3-chlorobenzyl)ethane-1,2-diamine Levamlodipine
Diseases
GWAS		Appendicular lean mass ( 33097823) Coronary artery disease ( 26343387 29212778) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Diastolic blood pressure ( 27618448 27841878 28739976) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Estimated glomerular filtration rate ( 31451708) Eyebrow thickness ( 26926045) Hypertension ( 27618448) Mean arterial pressure ( 27618448) Mean platelet volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (beta blocking agents) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Medication use (HMG CoA reductase inhibitors) ( 31015401) Myocardial infarction ( 33532862) Offspring birth weight ( 31043758) Periventricular white matter hyperintensities ( 32517579) Platelet distribution width ( 32888494) Stroke ( 30383316) Systolic blood pressure ( 30578418 27841878 27618448) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962)
Novel Interacting Genes		1 novel interacting genes: RHEB
Interacting Genes		47 interacting genes: A2M ACTN2 ACTN4 AGTR1 AKT1 APOE APP BDKRB2 BDNF CALM1 CAV1 CDC37 CEP55 EDNRB EFEMP1 EFEMP2 ELAVL1 ELAVL3 EXOC6 EXOSC1 FIS1 GCDH GOLGA2 H3-3A HSP90AA1 HTRA1 IKZF3 IMMT KANK2 MAGEA11 MAST1 MPRIP NMT1 NOSIP NOSTRIN PAXIP1 PI4K2A PPP2R5A PSEN1 PSEN2 RNF31 RNF32 SP1 ST13 TECR TXNDC11 UMPS
Entrez ID		4846
HPRD ID		01224
Ensembl ID		ENSG00000164867
Uniprot IDs		A0S0A6 P29474
PDB IDs		1M9J 1M9K 1M9M 1M9Q 1M9R 1NIW 2LL7 2MG5 2N8J 3EAH 3NOS 4D1O 4D1P 5UO8 5UO9 5UOA 5UOB 5UOC 5VVB 5VVC 5VVD 5XOF 6AV6 6AV7 6CIE 6CIF 6NH1 6NH2 6NH3 6NH4 6NH5 6NH6 6NH7 6NH8 6NHF 6POU 6POV 6POW 6POX 6POY 6POZ 6PP0 6PP1 6PP2 6PP3 6PP4 7M56 7TSG 7TSH 7TSI 7TSK 7TSL 7TSM 7TSN 7TSO 7TSP 7UAO 8FGN 8FGO 8FGP 8FGQ 8FGR 8FGS 8FGT 8FGU 8UFR 8UFS 8UFT 8UFU
Enriched GO Terms of Interacting Partners?		Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Nitric Oxide Metabolic Process Regulation Of Programmed Cell Death Positive Regulation Of Amyloid Fibril Formation Reactive Nitrogen Species Metabolic Process Nitric Oxide Metabolic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Apoptotic Process Positive Regulation Of Nitric Oxide Metabolic Process Regulation Of Blood Circulation Lipoprotein Particle Positive Regulation Of Protein Metabolic Process Regulation Of Apoptotic Signaling Pathway Regulation Of Amyloid Fibril Formation Angiotensin-activated Signaling Pathway Phospholipase C-activating Angiotensin-activated Signaling Pathway Positive Regulation Of Catabolic Process Positive Regulation Of Protein Catabolic Process Platelet Alpha Granule Lumen Establishment Of Protein Localization Regulation Of Small Molecule Metabolic Process Transmembrane Transporter Binding Protein-containing Complex Regulation Of Lipid Transport Amyloid Precursor Protein Metabolic Process Astrocyte Activation Involved In Immune Response Regulation Of Metal Ion Transport Positive Regulation Of Amyloid Precursor Protein Catabolic Process Maintenance Of Location In Cell Intracellular Signal Transduction Identical Protein Binding Blood Vessel Diameter Maintenance Regulation Of Tube Size Positive Regulation Of Cholesterol Metabolic Process Regulation Of Endothelial Cell Proliferation Intermediate-density Lipoprotein Particle Growth Factor Receptor Binding Type 1 Angiotensin Receptor Binding Positive Regulation Of Small Molecule Metabolic Process Maintenance Of Location Regulation Of Defense Response Regulation Of Monoatomic Cation Transmembrane Transport Vasoconstriction Aspartic Endopeptidase Activity, Intramembrane Cleaving Protein Homodimerization Activity Protein Binding Regulation Of Monoatomic Ion Transport Regulation Of System Process Inorganic Ion Homeostasis Regulation Of Monoatomic Ion Transmembrane Transport
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