NOS3 and NOSTRIN

Number of citations of the paper that reports this interaction (PMID 12446846)
18

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		NOS3	NOSTRIN
Gene Name		nitric oxide synthase 3 (endothelial cell)	nitric oxide synthase trafficking
Image
Gene Ontology Annotations	Cellular Component	Golgi Membrane Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Caveola Endocytic Vesicle Membrane	Nucleus Cytoskeleton Plasma Membrane Endocytic Vesicle Membrane
	Molecular Function	Actin Monomer Binding NADPH-hemoprotein Reductase Activity Nitric-oxide Synthase Activity Iron Ion Binding Protein Binding Calmodulin Binding FMN Binding Heme Binding Tetrahydrobiopterin Binding Arginine Binding Cadmium Ion Binding Flavin Adenine Dinucleotide Binding NADP Binding	DNA Binding Protein Binding
	Biological Process	Angiogenesis Ovulation From Ovarian Follicle In Utero Embryonic Development Blood Vessel Remodeling Regulation Of Sodium Ion Transport Regulation Of The Force Of Heart Contraction By Chemical Signal Regulation Of Systemic Arterial Blood Pressure By Endothelin Arginine Catabolic Process Nitric Oxide Biosynthetic Process Mitochondrion Organization Nitric Oxide Mediated Signal Transduction Blood Coagulation Regulation Of Blood Pressure Negative Regulation Of Cell Proliferation Response To Heat Negative Regulation Of Platelet Activation Negative Regulation Of Muscle Hyperplasia Smooth Muscle Hyperplasia Lung Development Positive Regulation Of Guanylate Cyclase Activity Lipopolysaccharide-mediated Signaling Pathway Response To Fluid Shear Stress Negative Regulation Of Potassium Ion Transport Endothelial Cell Migration Small Molecule Metabolic Process Positive Regulation Of Angiogenesis Negative Regulation Of Blood Pressure Positive Regulation Of Vasodilation Nitric Oxide Metabolic Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Blood Vessel Size Regulation Of Nitric-oxide Synthase Activity Negative Regulation Of Hydrolase Activity Interaction With Host Negative Regulation Of Calcium Ion Transport Oxidation-reduction Process Phagosome Maturation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors	Endocytosis Signal Transduction Small Molecule Metabolic Process Negative Regulation Of Transcription, DNA-templated Nitric Oxide Metabolic Process Regulation Of Nitric-oxide Synthase Activity
Pathways		Phagosomal maturation (early endosomal stage) VEGFA-VEGFR2 Pathway eNOS activation Metabolism of nitric oxide Platelet homeostasis Signaling by VEGF VEGFR2 mediated vascular permeability NOSTRIN mediated eNOS trafficking NOSIP mediated eNOS trafficking Latent infection of Homo sapiens with Mycobacterium tuberculosis Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation Nitric oxide stimulates guanylate cyclase eNOS activation and regulation	Metabolism of nitric oxide NOSTRIN mediated eNOS trafficking eNOS activation and regulation
Drugs		L-Arginine L-Citrulline Tetrahydrobiopterin Miconazole N,N-dimethylarginine L-N(Omega)-Nitroarginine-2,4-L-Diaminobutyric Amide L-2-Amino-4-(Guanidinooxy)Butyric Acid 3-Bromo-7-Nitroindazole N-{(4s)-4-Amino-5-[(2-Aminoethyl)Amino]Pentyl}-N\'-Nitroguanidine N-(3-(Aminomethyl)Benzyl)Acetamidine 1,2,4-Triazole-Carboxamidine L-N(Omega)-Nitroarginine-(4r)-Amino-L-Proline Amide S,S\'-(1,4-Phenylene-Bis(1,2-Ethanediyl))Bis-Isothiourea 7-Nitroindazole Ethylisothiourea 2-Aminothiazoline Se-Ethyl-Isoselenourea (6r,1\'r,2\'s)-5,6,7,8 Tetrahydrobiopterin 2,4-Diamino-6-Phenyl-5,6,7,8,-Tetrahydropteridine N1,N14-Bis((S-Methyl)Isothioureido)Tetradecane Hydroxydimethylarsine Oxide Heme 7-Nitroindazole-2-Carboxamidine 6-Nitroindazole N-Omega-Hydroxy-L-Arginine N5-Iminoethyl-L-Ornithine 5,6-Cyclic-Tetrahydropteridine S-Ethyl-N-Phenyl-Isothiourea S,S\'-(1,3-Phenylene-Bis(1,2-Ethanediyl))Bis-Isothiourea 6s-5,6,7,8-Tetrahydrobiopterin S-(Dimethylarsenic)Cysteine L-Homoarginine S-Isopropyl-Isothiourea Nitroarginine 5-Nitroindazole N-(Chlorophenyl)-N\'-Hydroxyguanidine (3S,5E)-3-propyl-3,4-dihydrothieno[2,3-f][1,4]oxazepin-5(2H)-imine 5-{4-[(3,5-DIFLUOROBENZYL)AMINO]PHENYL}-6-ETHYLPYRIMIDINE-2,4-DIAMINE ETHYL 4-[(4-METHYLPYRIDIN-2-YL)AMINO]PIPERIDINE-1-CARBOXYLATE N-{(3S,4S)-4-[(6-AMINO-4-METHYLPYRIDIN-2-YL)METHYL]PYRROLIDIN-3-YL}-N\'-(4-CHLOROBENZYL)ETHANE-1,2-DIAMINE N-{(3R,4S)-4-[(6-amino-4-methylpyridin-2-yl)methyl]pyrrolidin-3-yl}-N\'-(3-chlorobenzyl)ethane-1,2-diamine
Diseases
GWAS
Protein-Protein Interactions		46 interactors: A2M ACTN2 ACTN4 AGTR1 AKT1 APOE APP BDKRB2 BDNF CALM1 CAV1 CDC37 CEP55 EDNRB EFEMP1 EFEMP2 ELAVL1 ELAVL3 EXOC6 EXOSC1 FIS1 GCDH GOLGA2 H3F3A HSP90AA1 HTRA1 IMMT KANK2 MAGEA11 MAST1 MPRIP NMT1 NOSIP NOSTRIN PAXIP1 PI4K2A PPP2R5A PSEN1 PSEN2 RNF31 RNF32 SP1 ST13 TECR TXNDC11 UMPS	4 interactors: APC KDM1A NOS3 PRMT6
Entrez ID		4846	115677
HPRD ID		01224	06324
Ensembl ID		ENSG00000164867	ENSG00000163072
Uniprot IDs		A0S0A6 P29474	Q8IVI9
PDB IDs		1M9J 1M9K 1M9M 1M9Q 1M9R 1NIW 2LL7 3EAH 3NOS	2YUN
Enriched GO Terms of Interacting Partners?		Regulation Of Nitric-oxide Synthase Activity Regulation Of Oxidoreductase Activity Nitric Oxide Metabolic Process Reactive Nitrogen Species Metabolic Process Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Secretion Cellular Metal Ion Homeostasis Regulation Of Cellular Protein Metabolic Process Cellular Cation Homeostasis Regulation Of Body Fluid Levels Cellular Ion Homeostasis Metal Ion Homeostasis Regulation Of Protein Metabolic Process Cellular Chemical Homeostasis Regulation Of Cellular Amino Acid Metabolic Process Cellular Homeostasis Response To Abiotic Stimulus Ion Homeostasis Positive Regulation Of Cellular Protein Metabolic Process Blood Coagulation Homeostatic Process Hemostasis Reactive Oxygen Species Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process Exocytosis Positive Regulation Of Protein Metabolic Process Regulation Of Cellular Ketone Metabolic Process Platelet Degranulation Regulation Of Blood Vessel Size Secretion By Cell Chemical Homeostasis Regulation Of Tube Size Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Protein Metabolic Process Response To Wounding Negative Regulation Of Phosphorylation Regulation Of Cellular Component Organization Positive Regulation Of Oxidoreductase Activity Negative Regulation Of Ion Transport Wound Healing Establishment Of Localization In Cell Signaling Signal Transduction Negative Regulation Of Protein Phosphorylation Platelet Activation Positive Regulation Of Ion Transport Regulation Of Catalytic Activity Cell Communication Negative Regulation Of Cellular Metabolic Process	Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Chromosome Organization Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Primitive Erythrocyte Differentiation Negative Regulation Of Protein Metabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Chromosome Organization Regulation Of Myeloid Cell Differentiation Histone H3-R2 Methylation Smooth Muscle Hyperplasia Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process Organelle Organization Negative Regulation Of Signal Transduction Regulation Of Chromosome Organization Response To Stress Negative Regulation Of Signaling Smooth Muscle Adaptation Negative Regulation Of Odontogenesis Negative Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Muscle Hyperplasia Regulation Of Systemic Arterial Blood Pressure By Endothelin Regulation Of Apoptotic Process Regulation Of Cell Proliferation Regulation Of Cell Death Metaphase/anaphase Transition Of Mitotic Cell Cycle Leukocyte Differentiation Histone H3-K9 Demethylation Regulation Of The Force Of Heart Contraction By Chemical Signal Negative Regulation Of Histone H3-K4 Methylation Canonical Wnt Signaling Pathway Involved In Negative Regulation Of Apoptotic Process Histone H3-K4 Demethylation Arginine Catabolic Process Histone Modification Positive Regulation Of Megakaryocyte Differentiation Cell Development Negative Regulation Of Intracellular Signal Transduction Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Positive Regulation Of Guanylate Cyclase Activity Blood Coagulation Hemostasis Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Positive Regulation Of Hormone Biosynthetic Process Ovulation From Ovarian Follicle Positive Regulation Of Microtubule Polymerization Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
Tagcloud ?		antidepressants attacks bed favorable genotype genotypes gg glu298asp gt headaches instructed invited medications migraine month night nortriptyline numerical participate polymorphism prophylaxis rating rd st tcas tricyclic tt verbal
Tagcloud (Difference) ?		antidepressants attacks bed favorable genotype genotypes gg glu298asp gt headaches instructed invited medications migraine month night nortriptyline numerical participate polymorphism prophylaxis rating rd st tcas tricyclic tt verbal
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