PPP3R1 and WDPCP

		PPP3R1	WDPCP
Description		protein phosphatase 3 regulatory subunit B, alpha	WD repeat containing planar cell polarity effector
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Calcineurin Complex Protein Serine/threonine Phosphatase Complex Membrane Sarcolemma Synapse Schaffer Collateral - CA1 Synapse Hippocampal Mossy Fiber To CA3 Synapse Parallel Fiber To Purkinje Cell Synapse Postsynapse Glutamatergic Synapse	Cytoplasm Cytoskeleton Plasma Membrane Cilium Axoneme Cell Cortex Membrane Apical Plasma Membrane Cell Projection Axonemal Basal Plate
	Molecular Function	Phosphoprotein Phosphatase Activity Calcium-dependent Protein Serine/threonine Phosphatase Activity Calcium Ion Binding Protein Binding Calmodulin Binding Calcium-dependent Protein Serine/threonine Phosphatase Regulator Activity Phosphatase Binding Protein Domain Specific Binding Metal Ion Binding	Phosphatidylinositol Binding
	Biological Process	Branching Involved In Blood Vessel Morphogenesis Epithelial To Mesenchymal Transition Protein Import Into Nucleus Heart Development Schwann Cell Development Myelination In Peripheral Nervous System Calcineurin-NFAT Signaling Cascade Protein Localization To Nucleus Positive Regulation Of Transcription By RNA Polymerase II Lung Epithelial Cell Differentiation Positive Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Synaptic Vesicle Cycle Regulation Of Postsynaptic Neurotransmitter Receptor Internalization Postsynaptic Modulation Of Chemical Synaptic Transmission Positive Regulation Of Calcium Ion Import Across Plasma Membrane Negative Regulation Of Calcium Ion Import Across Plasma Membrane	Establishment Of Planar Polarity Kidney Development Auditory Receptor Cell Morphogenesis Smoothened Signaling Pathway Nervous System Development Regulation Of Fibroblast Migration Regulation Of Embryonic Cell Shape Neural Tube Development Cell Projection Organization Septin Cytoskeleton Organization Regulation Of Protein Localization Intraciliary Transport Embryonic Digit Morphogenesis Camera-type Eye Development Tongue Morphogenesis Cilium Organization Establishment Of Protein Localization Embryonic Organ Development Regulation Of Focal Adhesion Assembly Digestive System Development Roof Of Mouth Development Cilium Assembly Respiratory System Development Circulatory System Development Podocyte Cell Migration Regulation Of Ruffle Assembly Regulation Of Cilium Assembly Regulation Of Establishment Of Cell Polarity
Pathways		Activation of BAD and translocation to mitochondria DARPP-32 events Calcineurin activates NFAT Calcineurin activates NFAT FCERI mediated Ca+2 mobilization Ca2+ pathway CLEC7A (Dectin-1) induces NFAT activation
Drugs		Myristic acid Voclosporin
Diseases
GWAS		General cognitive ability ( 29844566) Height ( 25282103) Hip index ( 34021172) Intelligence (MTAG) ( 29326435) Schizophrenia ( 30285260) Urinary potassium excretion ( 31409800)	Academic attainment (English) ( 33594131) Anxiety ( 33859377) Asthma and attention deficit hyperactivity disorder ( 31619474) Childhood ear infection ( 27182965) Cutaneous malignant melanoma ( 26237428) Depression ( 33859377) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) General factor of neuroticism ( 30867560) General risk tolerance (MTAG) ( 30643258) Number of sexual partners ( 30643258) Obesity-related traits ( 23251661) Prostate cancer ( 31562322) Regular attendance at a religious group ( 29970889) Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		12 interacting genes: CABP1 CABP2 CABP5 CHRNA6 MAP3K5 MYC NAP1L2 NFATC1 NFATC2 PPP3CA PPP3CC RCAN1
Entrez ID		5534	51057
HPRD ID		03195	14228
Ensembl ID		ENSG00000221823	ENSG00000143951
Uniprot IDs		P63098	O95876
PDB IDs		1AUI 1M63 1MF8 2P6B 3LL8 4F0Z 4OR9 4ORA 4ORC 5SVE 6NUC 6NUF 6NUU 7U0T 9B9G 9CHU 9CHV 9CHX	7Q3D
Enriched GO Terms of Interacting Partners?		Calcineurin-NFAT Signaling Cascade Calcineurin-mediated Signaling Calcium-mediated Signaling Negative Regulation Of Smooth Muscle Cell Differentiation Intracellular Signaling Cassette Myotube Cell Development Regulation Of Calcineurin-mediated Signaling Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Smooth Muscle Cell Differentiation Calmodulin-dependent Protein Phosphatase Activity Calcium Channel Regulator Activity Negative Regulation Of Calcium Ion Import Across Plasma Membrane Calcineurin Complex Signal Transduction Striated Muscle Cell Development Negative Regulation Of Muscle Cell Differentiation Protein Serine/threonine Phosphatase Complex Positive Regulation Of Kidney Development Positive Regulation Of Calcium Ion Import Across Plasma Membrane Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Muscle Cell Development Regulation Of Calcium-mediated Signaling Regulation Of Cell Differentiation Negative Regulation Of Calcium Ion Import Regulation Of Calcium Ion Import Across Plasma Membrane Positive Regulation Of Calcineurin-NFAT Signaling Cascade Negative Regulation Of Cell Differentiation Regulation Of Developmental Process Intracellular Signal Transduction Positive Regulation Of Calcium Ion Import Skeletal Muscle Fiber Development Regulation Of Muscle Cell Differentiation Regulation Of Kidney Development Negative Regulation Of Calcium Ion Transmembrane Transport Negative Regulation Of Developmental Process Regulation Of Calcium Ion Import Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation Acinar Cell Proliferation Positive Regulation Of Acinar Cell Proliferation SCF Ubiquitin Ligase Complex Binding Negative Regulation Of Angiotensin-activated Signaling Pathway Negative Regulation Of Calcium Ion Transport Regulation Of Cell Proliferation Involved In Kidney Morphogenesis Axonemal Basal Plate Positive Regulation Of Calcium-mediated Signaling Calcium Ion Binding Positive Regulation Of Calcium Ion Transmembrane Transport Response To Ischemia Excitatory Postsynaptic Potential Negative Regulation Of Cation Transmembrane Transport	Calcium-dependent Protein Serine/threonine Phosphatase Activity Negative Regulation Of Cation Transmembrane Transport Negative Regulation Of Monoatomic Ion Transport Negative Regulation Of Transmembrane Transport Negative Regulation Of Monoatomic Ion Transmembrane Transport Cytosol Regulation Of Protein Stability Astral Microtubule Nuclear Polyadenylation-dependent MRNA Catabolic Process RRNA Transport RRNA Import Into Mitochondrion Positive Regulation Of Mitochondrial RNA Catabolic Process Mitochondrial Degradosome Mitochondrial MRNA Catabolic Process Polyribonucleotide Nucleotidyltransferase Activity Negative Regulation Of Hypoxia-inducible Factor-1alpha Signaling Pathway Positive Regulation Of Cholesterol Import Positive Regulation Of Endosome To Plasma Membrane Protein Transport Negative Regulation Of Calcium Ion Import Across Plasma Membrane Calcium-dependent Protein Serine/threonine Phosphatase Regulator Activity Calcineurin Complex ScaRNA Localization To Cajal Body N-acetyllactosaminide Beta-1,3-N-acetylglucosaminyltransferase Activity Poly-N-acetyllactosamine Biosynthetic Process Mitochondrial MRNA Polyadenylation Mitochondrial RNA 3'-end Processing Exoribonuclease Complex RNA Import Into Mitochondrion Positive Regulation Of MiRNA Catabolic Process Mitochondrial RNA 5'-end Processing Regulation Of Cholesterol Import Regulation Of Plasma Lipoprotein Particle Levels
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