CCDC91 and GGA2

Number of citations of the paper that reports this interaction (PubMedID 12808037)
46

Data Source:
HPRD (in vivo, in vitro)

		CCDC91	GGA2
Description		coiled-coil domain containing 91	golgi associated, gamma adaptin ear containing, ARF binding protein 2
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GO Annotations	Cellular Component	Nucleoplasm Golgi Apparatus Trans-Golgi Network Cytosol Membrane	Endosome Golgi Apparatus Trans-Golgi Network Endosome Membrane Membrane Clathrin-coated Vesicle Early Endosome Membrane
	Molecular Function	Protein Binding Identical Protein Binding	Protein Binding Small GTPase Binding Phosphatidylinositol Binding Ubiquitin Binding
	Biological Process	Protein Transport Golgi Vesicle Transport Golgi To Lysosome Transport	Intracellular Protein Transport Golgi To Plasma Membrane Transport Protein Transport Vesicle-mediated Transport Protein Localization To Cell Surface Golgi To Plasma Membrane Protein Transport
Pathways			TBC/RABGAPs Amyloid fiber formation
Drugs
Diseases
GWAS		Adverse response to drug ( 30420678) Appendicular lean mass ( 33097823) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Bone ultrasound measurement (velocity of sound) ( 28472463) Brain morphology (MOSTest) ( 32665545) Breast size ( 27182965) Chronic obstructive pulmonary disease ( 30804561 33909500) FEV1 ( 30804560) Finger osteoarthritis severity (hand Klsum) ( 33055079) Glaucoma (primary open-angle) ( 33627673) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Hand osteoarthritis severity (hand Klsum) ( 33055079) Heel bone mineral density ( 30598549) Height ( 25282103 23563607 31562340 20881960 28552196) High light scatter reticulocyte count ( 32888494) Hip circumference adjusted for BMI ( 34021172 25673412) Immature fraction of reticulocytes ( 32888494) Lumbar spine bone mineral density (trabecular) ( 27476799) Lung function (FEV1) ( 26635082 28166213) Lung function (FVC) ( 26635082 28166213 30804560) Lung function (low FEV1 vs high FEV1) ( 26423011) Lung function in never smokers (low FEV1 vs high FEV1) ( 26423011) Narrowest width of the femoral neck ( 30888730) Obesity-related traits ( 23251661) Ossification of the posterior longitudinal ligament of the spine ( 25064007) Osteoarthritis of the hand ( 28855172) Peak expiratory flow ( 30804560) Reticulocyte fraction of red cells ( 32888494) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 28448500 25673412 34021172)
Interacting Genes		11 interacting genes: AP1G1 CDC37 DAPK2 ECT2 EWSR1 GGA1 GGA2 LNX1 PRR5L SYNRG TESC	43 interacting genes: ADRA2B AFTPH AP1G1 APP ARF1 ARF3 ATXN1 BACE1 BACE2 CA8 CCDC91 CLINT1 CLTC ETS1 FBXO7 GGA1 GGA3 GOLGA2 GTPBP4 HGS HTT IGF2R JUN LRP3 M6PR MAP3K1 MEMO1 NPM1 PIN1 RABEP1 RABGEF1 RNF11 RTN4IP1 SORL1 SORT1 SPG21 STAB1 SYNRG TOLLIP TP53 TRIM23 VPS18 ZNF536
Entrez ID		55297	23062
HPRD ID		16905	09347
Ensembl ID		ENSG00000123106	ENSG00000103365
Uniprot IDs		Q05D28 Q7Z6B0	Q9UJY4
PDB IDs		1OM9	1MHQ
Enriched GO Terms of Interacting Partners?		Establishment Of Protein Localization Small GTPase Binding Clathrin-coated Vesicle Protein Transport Post-Golgi Vesicle-mediated Transport AP-1 Adaptor Complex Trans-Golgi Network Protein Localization To Plasma Membrane Golgi To Plasma Membrane Protein Transport Protein Localization To Cell Surface Intracellular Protein Transport Protein Localization To Cell Periphery Intracellular Protein Localization Regulation Of Cytokinesis, Actomyosin Contractile Ring Assembly Establishment Of Protein Localization To Plasma Membrane Positive Regulation Of Eosinophil Chemotaxis Autophagosome Lumen Golgi Vesicle Transport Golgi To Plasma Membrane Transport Protein Localization To Membrane Synaptic Vesicle Budding From Endosome Golgi Apparatus HSP90-CDC37 Chaperone Complex Positive Regulation Of Eosinophil Migration Positive Regulation Of Intracellular Protein Transport Positive Regulation Of Transport Centralspindlin Complex Regulation Of Protein Phosphorylation Positive Regulation Of Sodium:proton Antiporter Activity Ubiquitin Binding Cellular Localization Phosphatidylinositol Binding Regulation Of Phosphorylation Dolichyl-phosphate-mannose-protein Mannosyltransferase Activity Basolateral Protein Secretion Positive Regulation Of Natural Killer Cell Degranulation	Vesicle-mediated Transport Intracellular Transport Early Endosome Endosome Cellular Localization Establishment Of Protein Localization Establishment Of Localization In Cell Protein Transport Intracellular Protein Transport Endocytosis Golgi Apparatus Lysosomal Transport Trans-Golgi Network Import Into Cell Intracellular Protein Localization Vacuolar Transport Clathrin-coated Vesicle Golgi Vesicle Transport Recycling Endosome Post-Golgi Vesicle-mediated Transport Receptor-mediated Endocytosis Protein Targeting To Lysosome Protein Targeting Perinuclear Region Of Cytoplasm Establishment Of Protein Localization To Organelle Protein Targeting To Vacuole Protein-containing Complex Trans-Golgi Network Membrane Protein Localization To Lysosome Endosome Membrane Establishment Of Protein Localization To Vacuole Early Endosome Membrane Cytoplasmic Vesicle Cytosolic Transport Clathrin-coated Pit Retromer Complex Binding Golgi To Lysosome Transport Nuclear Envelope Lumen Lysosome Protein Localization To Organelle AP-1 Adaptor Complex Endosomal Transport Protein Localization To Vacuole Ubiquitin Binding Protein Transporter Activity Regulation Of Amyloid Precursor Protein Catabolic Process Trans-Golgi Network Transport Vesicle Golgi To Vacuole Transport Vesicle-mediated Transport To The Plasma Membrane Amyloid-beta Metabolic Process
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