CLOCK and DELEC1

Number of citations of the paper that reports this interaction (PubMedID 23555304)
45

Data Source:
BioGRID (two hybrid)

		CLOCK	DELEC1
Description		clock circadian regulator	deleted in esophageal cancer 1
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Chromosome Cytoplasm Cytosol Chromatoid Body CLOCK-BMAL Transcription Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Histone Acetyltransferase Activity Protein Binding Transferase Activity Acyltransferase Activity Chromatin DNA Binding Sequence-specific DNA Binding Protein Dimerization Activity Protein-lysine-acetyltransferase Activity E-box Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	DNA Damage Checkpoint Signaling Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Protein Acetylation DNA Damage Response Signal Transduction Spermatogenesis Circadian Rhythm Photoperiodism Regulation Of Gene Expression Circadian Regulation Of Gene Expression Regulation Of Hair Cycle Regulation Of Circadian Rhythm Positive Regulation Of Circadian Rhythm Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Positive Regulation Of Inflammatory Response Regulation Of Insulin Secretion Positive Regulation Of NF-kappaB Transcription Factor Activity Response To Redox State Cellular Response To Ionizing Radiation Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway	Negative Regulation Of Cell Population Proliferation
Pathways		BMAL1:CLOCK,NPAS2 activates circadian expression BMAL1:CLOCK,NPAS2 activates circadian expression PPARA activates gene expression HATs acetylate histones Heme signaling Expression of BMAL (ARNTL), CLOCK, and NPAS2 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK
Drugs
Diseases
GWAS		A body shape index ( 34021172) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Coronary artery disease ( 33020668) Cortical surface area (MOSTest) ( 32665545) Height ( 25282103) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Neutrophil percentage of white cells ( 32888494) Personality dimensions ( 18957941) Subcortical volume (MOSTest) ( 32665545) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		26 interacting genes: ARNT BHLHE41 BMAL1 BMAL2 CRY1 CRY2 CSNK1E CSNK2B DBP DELEC1 EP300 KAT2B PER2 PER3 PPP1CA PPP1CB PPP1CC PPP2R1B PPP2R5D PPP2R5E RARA RHOA RORB RORC RXRA SIRT1	29 interacting genes: BHLHE41 BMAL1 CIPC CLOCK CRY1 CRY2 CSNK1E CSNK2A1 CSNK2A2 CSNK2B EZH2 FBXL15 GSK3B NFIL3 NONO NPAS2 NR1D2 PER1 PER2 PPP1CA PPP1CB PPP1CC PPP2CA PPP2R1A PPP2R1B PPP2R5D PPP2R5E RORB RORC
Entrez ID		9575	50514
HPRD ID		03508	16068
Ensembl ID		ENSG00000134852	ENSG00000173077
Uniprot IDs		O15516 Q3ZCT4 Q53EU0
PDB IDs		4H10 6QPJ
Enriched GO Terms of Interacting Partners?		Circadian Regulation Of Gene Expression Rhythmic Process Circadian Rhythm Regulation Of Circadian Rhythm Entrainment Of Circadian Clock Entrainment Of Circadian Clock By Photoperiod Photoperiodism Regulation Of Transcription By RNA Polymerase II Response To Light Stimulus Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Intracellular Receptor Signaling Pathway Chromatin Nucleus Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of RNA Metabolic Process Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Glucose Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Response To Radiation Nuclear Receptor Activity Gluconeogenesis Hexose Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Carbohydrate Metabolic Process PTW/PP1 Phosphatase Complex Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Aryl Hydrocarbon Receptor Complex Negative Regulation Of Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Metabolic Process Regulation Of Small Molecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Receptor Binding Negative Regulation Of Circadian Rhythm Carbohydrate Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Glucose Metabolic Process Positive Regulation Of RNA Metabolic Process Peptidyl-lysine Acetylation Negative Regulation Of Macromolecule Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Macromolecule Biosynthetic Process	Rhythmic Process Regulation Of Circadian Rhythm Circadian Rhythm Circadian Regulation Of Gene Expression Photoperiodism Entrainment Of Circadian Clock By Photoperiod Entrainment Of Circadian Clock Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Protein Phosphatase Type 2A Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Circadian Rhythm Protein Kinase CK2 Complex Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Chromatin Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process CLOCK-BMAL Transcription Complex E-box Binding Glycogen Metabolic Process Response To Light Stimulus Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process Polysaccharide Metabolic Process PTW/PP1 Phosphatase Complex Energy Reserve Metabolic Process Regulation Of Metabolic Process Regulation Of Type B Pancreatic Cell Development Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Signal Transduction Protein Serine/threonine Phosphatase Activity Regulation Of Signal Transduction Regulation Of Gene Expression Regulation Of RNA Metabolic Process Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Cell Communication Negative Regulation Of Signaling Protein Phosphatase Regulator Activity
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