CLOCK and RARA

Number of citations of the paper that reports this interaction (PubMedID 11439184)
0

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BioGRID (pull down)

		CLOCK	RARA
Description		clock circadian regulator	retinoic acid receptor alpha
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Chromosome Cytoplasm Cytosol Chromatoid Body CLOCK-BMAL Transcription Complex	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Nucleolus Cytoplasm Cytosol Plasma Membrane Actin Cytoskeleton Dendrite Protein-containing Complex Perinuclear Region Of Cytoplasm RNA Polymerase II Transcription Regulator Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Histone Acetyltransferase Activity Protein Binding Transferase Activity Acyltransferase Activity Chromatin DNA Binding Sequence-specific DNA Binding Protein Dimerization Activity Protein-lysine-acetyltransferase Activity E-box Binding Sequence-specific Double-stranded DNA Binding	MRNA Regulatory Element Binding Translation Repressor Activity Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity Transcription Coactivator Binding Retinoic Acid Binding DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Signaling Receptor Binding Protein Binding Zinc Ion Binding Enzyme Binding Protein Domain Specific Binding Chromatin DNA Binding Histone Deacetylase Binding Protein Kinase B Binding Sequence-specific DNA Binding Retinoic Acid-responsive Element Binding Metal Ion Binding MRNA 5'-UTR Binding Protein Kinase A Binding Alpha-actinin Binding Heterocyclic Compound Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	DNA Damage Checkpoint Signaling Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Protein Acetylation DNA Damage Response Signal Transduction Spermatogenesis Circadian Rhythm Photoperiodism Regulation Of Gene Expression Circadian Regulation Of Gene Expression Regulation Of Hair Cycle Regulation Of Circadian Rhythm Positive Regulation Of Circadian Rhythm Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Positive Regulation Of Inflammatory Response Regulation Of Insulin Secretion Positive Regulation Of NF-kappaB Transcription Factor Activity Response To Redox State Cellular Response To Ionizing Radiation Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Ureteric Bud Development Neural Tube Closure Liver Development Glandular Epithelial Cell Development Outflow Tract Septum Morphogenesis Growth Plate Cartilage Development Regulation Of DNA-templated Transcription Protein Phosphorylation Germ Cell Development Spermatogenesis Female Pregnancy Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Male Gonad Development Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Translation Hippocampus Development Cell Differentiation Prostate Gland Development Regulation Of Granulocyte Differentiation Negative Regulation Of Granulocyte Differentiation Embryonic Camera-type Eye Development Regulation Of Myelination Response To Estradiol Response To Retinoic Acid Negative Regulation Of Type II Interferon Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-13 Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of Interleukin-5 Production Response To Vitamin A Response To Cytokine Multicellular Organism Growth MRNA Transcription By RNA Polymerase II Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Apoptotic Cell Clearance Response To Ethanol Negative Regulation Of Cell Differentiation Positive Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Cell Cycle Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Synaptic Plasticity Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Binding Ventricular Cardiac Muscle Cell Differentiation Sertoli Cell Fate Commitment Limb Development Face Development Bone Development Trachea Cartilage Development Chondroblast Differentiation Negative Regulation Of Cartilage Development Cellular Response To Lipopolysaccharide Cellular Response To Retinoic Acid Cellular Response To Estrogen Stimulus Nuclear Protein Quality Control By The Ubiquitin-proteasome System Regulation Of Hematopoietic Progenitor Cell Differentiation Negative Regulation Of MiRNA Transcription
Pathways		BMAL1:CLOCK,NPAS2 activates circadian expression BMAL1:CLOCK,NPAS2 activates circadian expression PPARA activates gene expression HATs acetylate histones Heme signaling Expression of BMAL (ARNTL), CLOCK, and NPAS2 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK	Nuclear Receptor transcription pathway SUMOylation of intracellular receptors Signaling by Retinoic Acid Activation of anterior HOX genes in hindbrain development during early embryogenesis Transcriptional regulation of granulopoiesis Transcriptional regulation of granulopoiesis TGFBR3 expression
Drugs			Adapalene Acitretin Alitretinoin Tretinoin Tazarotene Etretinate Isotretinoin Tamibarotene LGD-1550 Trifarotene
Diseases			Isolated orofacial clefts, including: Cleft lip with or without cleft palate; Cleft palate Acute myeloid leukemia (AML)
GWAS		A body shape index ( 34021172) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Coronary artery disease ( 33020668) Cortical surface area (MOSTest) ( 32665545) Height ( 25282103) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Neutrophil percentage of white cells ( 32888494) Personality dimensions ( 18957941) Subcortical volume (MOSTest) ( 32665545) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Asthma ( 31619474)
Interacting Genes		26 interacting genes: ARNT BHLHE41 BMAL1 BMAL2 CRY1 CRY2 CSNK1E CSNK2B DBP DELEC1 EP300 KAT2B PER2 PER3 PPP1CA PPP1CB PPP1CC PPP2R1B PPP2R5D PPP2R5E RARA RHOA RORB RORC RXRA SIRT1	96 interacting genes: ACTN4 AKT1 ALOX15B ALX1 ARID1A ARID5A BAG1 BBS4 BMAL1 BTG1 CCND3 CCNDBP1 CDK7 CEBPA CLOCK CNOT1 COPS2 E2F1 ESR1 FGFR1 FN1 FOXO1 GADD45G GATA2 HDAC1 HDAC3 HDAC4 HMGA1 HR IRX4 ITGB1BP2 KAT2B KDM5A KLF5 LRIF1 MAPK6 MCRS1 MDM2 MECR MED1 MED25 MED6 MMS19 NCOA1 NCOA2 NCOA3 NCOA6 NCOR1 NCOR2 NKX2-1 NPAS2 NR0B2 NR1H2 NR1H3 NR2C1 NR2E3 NR3C1 NRBF2 NRIP1 NRIP2 NSD1 PARP1 PHF8 PIN1 PLEKHF2 PML PNRC2 POU2F1 PRAME PRDX6 PRKCA PSMC5 RXRA RXRB RXRG S100A3 SIRT1 SMARCD3 SNW1 SP1 SPEN SRC SRF STAT5B TADA3 TEKT4 THRB TNIP1 TOP2B TRIM24 TRIP4 UBE3A UBQLN1 UBR5 USP7 ZBTB16
Entrez ID		9575	5914
HPRD ID		03508	06769
Ensembl ID		ENSG00000134852	ENSG00000131759
Uniprot IDs		O15516 Q3ZCT4 Q53EU0	A8K840 A8MUP8 F1D8N9 P10276 Q6I9R7
PDB IDs		4H10 6QPJ	1DKF 1DSZ 3A9E 3KMR 3KMZ 4DQM 5K13 6XWG 7AOS 7APO 7QAA 7WQQ 9GFE 9GFI
Enriched GO Terms of Interacting Partners?		Circadian Regulation Of Gene Expression Rhythmic Process Circadian Rhythm Regulation Of Circadian Rhythm Entrainment Of Circadian Clock Entrainment Of Circadian Clock By Photoperiod Photoperiodism Regulation Of Transcription By RNA Polymerase II Response To Light Stimulus Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Intracellular Receptor Signaling Pathway Chromatin Nucleus Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of RNA Metabolic Process Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Glucose Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Response To Radiation Nuclear Receptor Activity Gluconeogenesis Hexose Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Carbohydrate Metabolic Process PTW/PP1 Phosphatase Complex Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Aryl Hydrocarbon Receptor Complex Negative Regulation Of Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Metabolic Process Regulation Of Small Molecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Receptor Binding Negative Regulation Of Circadian Rhythm Carbohydrate Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Glucose Metabolic Process Positive Regulation Of RNA Metabolic Process Peptidyl-lysine Acetylation Negative Regulation Of Macromolecule Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Macromolecule Biosynthetic Process	Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Nucleus Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Nucleoplasm Positive Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Chromatin Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Nuclear Retinoic Acid Receptor Binding Nuclear Receptor Binding Nuclear Receptor-mediated Signaling Pathway Negative Regulation Of Metabolic Process Hormone-mediated Signaling Pathway Intracellular Receptor Signaling Pathway Response To Hormone Nuclear Retinoid X Receptor Binding Rhythmic Process Transcription Regulator Complex Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Transcription Coactivator Activity Retinoic Acid Receptor Signaling Pathway Sequence-specific DNA Binding Regulation Of Developmental Process Chromatin Binding Nuclear Estrogen Receptor Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin DNA Binding
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