DELEC1 and PPP2R5E

Number of citations of the paper that reports this interaction (PubMedID 23555304)
45

Data Source:
BioGRID (two hybrid)

		DELEC1	PPP2R5E
Description		deleted in esophageal cancer 1	protein phosphatase 2 regulatory subunit B'epsilon
Image		No pdb structure
GO Annotations	Cellular Component		Protein Phosphatase Type 2A Complex Nucleus Cytoplasm Cytosol
	Molecular Function		Protein Binding Protein Phosphatase Regulator Activity Protein Phosphatase Activator Activity
	Biological Process	Negative Regulation Of Cell Population Proliferation	Signal Transduction
Pathways			Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Co-stimulation by CD28 Co-inhibition by CTLA4 Platelet sensitization by LDL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Signaling by GSK3beta mutants CTNNB1 S33 mutants aren't phosphorylated CTNNB1 S37 mutants aren't phosphorylated CTNNB1 S45 mutants aren't phosphorylated CTNNB1 T41 mutants aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex RHO GTPases Activate Formins RAF activation Negative regulation of MAPK pathway PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS			Low density lipoprotein cholesterol levels ( 32154731) Response to antineoplastic agents ( 21659360) Schizophrenia ( 33169155) Systolic blood pressure ( 28135244) Triglyceride levels ( 32154731)
Interacting Genes		29 interacting genes: BHLHE41 BMAL1 CIPC CLOCK CRY1 CRY2 CSNK1E CSNK2A1 CSNK2A2 CSNK2B EZH2 FBXL15 GSK3B NFIL3 NONO NPAS2 NR1D2 PER1 PER2 PPP1CA PPP1CB PPP1CC PPP2CA PPP2R1A PPP2R1B PPP2R5D PPP2R5E RORB RORC	23 interacting genes: APP BHLHE41 BTG3 BUB1B CHEK2 CLOCK CRY1 CRY2 CSNK1E CSNK2B DELEC1 DOCK9 ENO1 FBXW11 GPRASP3 OGT PPP1CA PPP2CA PPP2R1B RACGAP1 RORC SGO1 SMAD9
Entrez ID		50514	5529
HPRD ID		16068	09040
Ensembl ID		ENSG00000173077	ENSG00000154001
Uniprot IDs			Q16537
PDB IDs			8UWB
Enriched GO Terms of Interacting Partners?		Rhythmic Process Regulation Of Circadian Rhythm Circadian Rhythm Circadian Regulation Of Gene Expression Photoperiodism Entrainment Of Circadian Clock By Photoperiod Entrainment Of Circadian Clock Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Protein Phosphatase Type 2A Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Circadian Rhythm Protein Kinase CK2 Complex Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Chromatin Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process CLOCK-BMAL Transcription Complex E-box Binding Glycogen Metabolic Process Response To Light Stimulus Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process Polysaccharide Metabolic Process PTW/PP1 Phosphatase Complex Energy Reserve Metabolic Process Regulation Of Metabolic Process Regulation Of Type B Pancreatic Cell Development Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Signal Transduction Protein Serine/threonine Phosphatase Activity Regulation Of Signal Transduction Regulation Of Gene Expression Regulation Of RNA Metabolic Process Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Cell Communication Negative Regulation Of Signaling Protein Phosphatase Regulator Activity	Circadian Regulation Of Gene Expression Circadian Rhythm Rhythmic Process Regulation Of Circadian Rhythm Photoperiodism Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Regulation Of Small Molecule Metabolic Process Nucleus Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Regulation Of Signal Transduction Blue Light Signaling Pathway DNA (6-4) Photolyase Activity Deoxyribodipyrimidine Photo-lyase Activity Blue Light Photoreceptor Activity RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Regulation Of Carbohydrate Catabolic Process Response To Lead Ion Positive Regulation Of Circadian Rhythm Regulation Of ATP Metabolic Process Entrainment Of Circadian Clock By Photoperiod Regulation Of Purine Nucleotide Metabolic Process Negative Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Entrainment Of Circadian Clock Positive Regulation Of Proteolysis Negative Regulation Of Signal Transduction Regulation Of Proteolysis Meiotic Sister Chromatid Cohesion, Centromeric Negative Regulation Of Glucocorticoid Secretion Regulation Of Glucose Metabolic Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cytoplasm Response To Radiation Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Sister Chromatid Cohesion Response To Blue Light Regulation Of Generation Of Precursor Metabolites And Energy Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Glycolytic Process Positive Regulation Of Small Molecule Metabolic Process Regulation Of Cell Cycle Negative Regulation Of RNA Metabolic Process E-box Binding Photoreceptor Activity Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?