DELEC1 and PER2

Number of citations of the paper that reports this interaction (PubMedID 23555304)
45

Data Source:
BioGRID (two hybrid)

		DELEC1	PER2
Description		deleted in esophageal cancer 1	period circadian regulator 2
Image		No pdb structure
GO Annotations	Cellular Component		Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Perinuclear Region Of Cytoplasm Cry-Per Complex
	Molecular Function		Transcription Cis-regulatory Region Binding Transcription Corepressor Binding Transcription Coactivator Activity Protein Binding
	Biological Process	Negative Regulation Of Cell Population Proliferation	Negative Regulation Of Transcription By RNA Polymerase II Response To Ischemia Neural Retina Development Glycogen Biosynthetic Process Gluconeogenesis Chromatin Remodeling Fatty Acid Metabolic Process Circadian Rhythm Regulation Of Vasoconstriction Lactate Biosynthetic Process Negative Regulation Of Protein Ubiquitination Circadian Regulation Of Gene Expression Regulation Of Circadian Rhythm Negative Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Rhythmic Process Regulation Of Neurogenesis Regulation Of Insulin Secretion White Fat Cell Differentiation Regulation Of Cell Cycle Regulation Of Glutamate Uptake Involved In Transmission Of Nerve Impulse Negative Regulation Of Fat Cell Proliferation Positive Regulation Of Cold-induced Thermogenesis
Pathways			Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex Phosphorylation and nuclear translocation of the CRY:PER:kinase complex Degradation of CRY and PER proteins Degradation of CRY and PER proteins
Drugs
Diseases			Familial advanced sleep phase syndrome
GWAS			Chronotype ( 26955885 27494321 30696823) Morning vs. evening chronotype ( 26835600 26955885 27494321)
Interacting Genes		29 interacting genes: BHLHE41 BMAL1 CIPC CLOCK CRY1 CRY2 CSNK1E CSNK2A1 CSNK2A2 CSNK2B EZH2 FBXL15 GSK3B NFIL3 NONO NPAS2 NR1D2 PER1 PER2 PPP1CA PPP1CB PPP1CC PPP2CA PPP2R1A PPP2R1B PPP2R5D PPP2R5E RORB RORC	20 interacting genes: BHLHE41 CLOCK CRY1 CRY2 CSNK1D CSNK1E CSNK2B DELEC1 ELOA LENG8 LMO4 MLH1 PER1 PER3 RORC TIMELESS TP53 TPT1 TPTEP2-CSNK1E UBL4A
Entrez ID		50514	8864
HPRD ID		16068	04575
Ensembl ID		ENSG00000173077	ENSG00000132326
Uniprot IDs			O15055
PDB IDs			6OF7 8D7M 8D7N 8D7O
Enriched GO Terms of Interacting Partners?		Rhythmic Process Regulation Of Circadian Rhythm Circadian Rhythm Circadian Regulation Of Gene Expression Photoperiodism Entrainment Of Circadian Clock By Photoperiod Entrainment Of Circadian Clock Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Protein Phosphatase Type 2A Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Circadian Rhythm Protein Kinase CK2 Complex Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Chromatin Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process CLOCK-BMAL Transcription Complex E-box Binding Glycogen Metabolic Process Response To Light Stimulus Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process Polysaccharide Metabolic Process PTW/PP1 Phosphatase Complex Energy Reserve Metabolic Process Regulation Of Metabolic Process Regulation Of Type B Pancreatic Cell Development Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Signal Transduction Protein Serine/threonine Phosphatase Activity Regulation Of Signal Transduction Regulation Of Gene Expression Regulation Of RNA Metabolic Process Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Cell Communication Negative Regulation Of Signaling Protein Phosphatase Regulator Activity	Circadian Rhythm Circadian Regulation Of Gene Expression Regulation Of Circadian Rhythm Rhythmic Process Photoperiodism Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Entrainment Of Circadian Clock Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription E-box Binding Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Blue Light Signaling Pathway DNA (6-4) Photolyase Activity Deoxyribodipyrimidine Photo-lyase Activity Blue Light Photoreceptor Activity Response To Light Stimulus Nucleus Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of Macromolecule Metabolic Process Kinase Binding Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Glucocorticoid Secretion Response To Radiation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process DNA Damage Response Response To Blue Light Regulation Of Primary Metabolic Process Cellular Response To Radiation Photoreceptor Activity DNA-binding Transcription Factor Binding Negative Regulation Of Circadian Rhythm Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Regulation Of Thymocyte Apoptotic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Non-canonical Wnt Signaling Pathway Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Intracellular Signal Transduction Hematopoietic Or Lymphoid Organ Development Regulation Of Glucose Metabolic Process Transcription Cis-regulatory Region Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Positive Regulation Of Circadian Rhythm Regulation Of RNA Biosynthetic Process
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