MOS and MAP2K2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MOS	MAP2K2
Description		MOS proto-oncogene, serine/threonine kinase	mitogen-activated protein kinase kinase 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Extracellular Region Nucleus Cytoplasm Mitochondrion Early Endosome Late Endosome Peroxisomal Membrane Endoplasmic Reticulum Golgi Apparatus Cytosol Microtubule Cell-cell Junction Focal Adhesion Cytoplasmic Side Of Plasma Membrane Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity MAP-kinase Scaffold Activity Protein Binding ATP Binding Kinase Activity Transferase Activity PDZ Domain Binding Protein Serine/threonine Kinase Activator Activity Metal Ion Binding Molecular Adaptor Activity Scaffold Protein Binding Protein Serine Kinase Activity
	Biological Process	MAPK Cascade Meiotic Spindle Organization Oocyte Maturation Chromatin Organization Signal Transduction Regulation Of Meiotic Nuclear Division Positive Regulation Of MAPK Cascade Establishment Of Meiotic Spindle Orientation Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Metaphase/anaphase Transition Of Meiotic Cell Cycle	MAPK Cascade Heart Development Positive Regulation Of Gene Expression Schwann Cell Development Thyroid Gland Development Regulation Of Stress-activated MAPK Cascade Peptidyl-serine Autophosphorylation ERBB2-ERBB3 Signaling Pathway Myelination Positive Regulation Of DNA-templated Transcription Insulin-like Growth Factor Receptor Signaling Pathway Thymus Development Regulation Of Axon Regeneration Positive Regulation Of Axonogenesis Face Development Lung Morphogenesis Trachea Formation Epithelial Cell Proliferation Involved In Lung Morphogenesis ERK1 And ERK2 Cascade Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Golgi Inheritance Positive Regulation Of Cell Motility Regulation Of Early Endosome To Late Endosome Transport
Pathways			MAPK1 (ERK2) activation Frs2-mediated activation Signal transduction by L1 Uptake and function of anthrax toxins RAF activation MAP2K and MAPK activation Negative feedback regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by MAP2K mutants Signaling by RAF1 mutants
Drugs			Bosutinib Trametinib Selumetinib Binimetinib Fostamatinib Pimasertib
Diseases			Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
GWAS		Height ( 18391951) Refractive error ( 32231278)	Eosinophil count ( 32888494) Heel bone mineral density ( 30598549) Height ( 29782485) Lymphocyte count ( 32888494) Pulse pressure ( 30224653) White blood cell count ( 32888494)
Interacting Genes		57 interacting genes: ACTN2 ASB6 ATRIP BICD2 BMPR2 BORCS6 CALCOCO2 CBY2 CCDC102B CCDC136 CCDC33 CCNDBP1 CFTR DYDC1 DZIP1 GFAP GOLGA2 GOLGA6A GOLGA6L9 GRAP2 HOMER3 HOMEZ HSPA1A IKZF1 KCTD6 KIFAP3 KIFC3 KRT13 KRT15 KRT27 KRT31 KRT33B KRT34 KRT40 KRTAP1-3 LZTS2 MAP2K2 MEOX2 MID2 MIPOL1 MTMR9 MTUS2 MYOD1 NBPF19 NOTCH2NLA PICK1 PPP2R5A PSTPIP1 RHOU SEC24C SSX2IP TP53BP2 TRAF1 TRAF2 TRIM27 USHBP1 ZBTB2	20 interacting genes: ARAF BRAF CASP9 CCNDBP1 CNKSR1 COPS5 DUSP3 GRIN1 GRIN2D HNRNPK LAMTOR3 LIG4 MAPK1 MAPK3 MAPK8 MOS RAF1 RGS12 RIPOR2 ZNF207
Entrez ID		4342	5605
HPRD ID		01816	03164
Ensembl ID		ENSG00000172680	ENSG00000126934
Uniprot IDs		P00540	B3KS97 P36507
PDB IDs			1S9I 4H3Q
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Skin Epidermis Cytoskeleton Intermediate Filament Organization Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament Structural Molecule Activity Supramolecular Fiber Organization Identical Protein Binding Cytosol Cytoskeleton Organization Protein Binding Epithelial Cell Differentiation Morphogenesis Of An Epithelium Organelle Organization Centrosome Tissue Morphogenesis Thioesterase Binding Cytoplasm Golgi Cis Cisterna	MAPK Cascade MAP Kinase Kinase Kinase Activity Face Development Thyroid Gland Development Intracellular Signal Transduction Protein Serine Kinase Activity ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Intracellular Signaling Cassette Protein Serine/threonine Kinase Activity Thymus Development Regulation Of Signal Transduction Regulation Of MAPK Cascade MAP Kinase Activity Pseudopodium Protein Kinase Activity Schwann Cell Development ERBB Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Peptidyl-serine Phosphorylation Stress-activated MAPK Cascade ERBB2 Signaling Pathway Regulation Of Intracellular Signal Transduction Stress-activated Protein Kinase Signaling Cascade Signal Transduction Kinase Activity Interleukin-34-mediated Signaling Pathway Hematopoietic Or Lymphoid Organ Development Regulation Of Peptidyl-serine Phosphorylation Cytoplasm Regulation Of Chromosome Organization Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Golgi Inheritance Caveolin-mediated Endocytosis Positive Regulation Of Macrophage Proliferation Positive Regulation Of Synaptic Transmission NMDA Glutamate Receptor Activity Glutamate Binding Cardiac Neural Crest Cell Development Involved In Heart Development Trachea Formation Regulation Of Granulocyte Chemotaxis Response To Epidermal Growth Factor Negative Regulation Of Apoptotic Process ERK1 And ERK2 Cascade Long-term Synaptic Potentiation Protein Phosphorylation Negative Regulation Of Programmed Cell Death NMDA Selective Glutamate Receptor Complex Glutamate-gated Calcium Ion Channel Activity
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?