MOS and SEC24C

Number of citations: 56 (PubMedID 25416956)
Data Source: BioGRID (two hybrid)

		MOS	SEC24C
Name		MOS proto-oncogene, serine/threonine kinase	SEC24 homolog C, COPII component
Structure		No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol ER To Golgi Transport Vesicle Membrane Membrane COPII Vesicle Coat Cytoplasmic Vesicle Endoplasmic Reticulum Exit Site
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	SNARE Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	MAPK Cascade Meiotic Spindle Organization Oocyte Maturation Chromatin Organization Signal Transduction Regulation Of Meiotic Nuclear Division Positive Regulation Of MAPK Cascade Establishment Of Meiotic Spindle Orientation Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Metaphase/anaphase Transition Of Meiotic Cell Cycle	In Utero Embryonic Development Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Protein Transport Vesicle-mediated Transport COPII-coated Vesicle Cargo Loading
Pathways		None	Regulation of cholesterol biosynthesis by SREBP (SREBF) COPII-mediated vesicle transport MHC class II antigen presentation Cargo concentration in the ER SARS-CoV-2 activates/modulates innate and adaptive immune responses Antigen Presentation: Folding, assembly and peptide loading of class I MHC
GWAS		Height ( 18391951 ) Refractive error ( 32231278 )	Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143 ) Crohn's disease ( 28067908 ) Lung function (FEV1) ( 30175238 ) Self-rated health ( 27864402 )
Interacting Genes		57 interacting genes: ACTN2 ASB6 ATRIP BICD2 BMPR2 BORCS6 CALCOCO2 CBY2 CCDC102B CCDC136 CCDC33 CCNDBP1 CFTR DYDC1 DZIP1 GFAP GOLGA2 GOLGA6A GOLGA6L9 GRAP2 HOMER3 HOMEZ HSPA1A IKZF1 KCTD6 KIFAP3 KIFC3 KRT13 KRT15 KRT27 KRT31 KRT33B KRT34 KRT40 KRTAP1-3 LZTS2 MAP2K2 MEOX2 MID2 MIPOL1 MTMR9 MTUS2 MYOD1 NBPF19 NOTCH2NLA PICK1 PPP2R5A PSTPIP1 RHOU SEC24C SSX2IP TP53BP2 TRAF1 TRAF2 TRIM27 USHBP1 ZBTB2	10 interacting genes: APP CRYAA FBXO7 MIA2 MIA3 MOS SEC23A SEC23B SPP1 WIPF1
Entrez ID		4342	9632
HPRD ID		01816	06217
Ensembl ID		ENSG00000172680	ENSG00000176986
Uniprot IDs		P00540	P53992
PDB IDs		Not available	3EH2 6PU1 8CL3
GO Terms Enriched among Interactors		Structural Constituent Of Skin Epidermis Cytoskeleton Intermediate Filament Organization Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament Structural Molecule Activity Supramolecular Fiber Organization Identical Protein Binding Cytosol Cytoskeleton Organization Protein Binding Epithelial Cell Differentiation Morphogenesis Of An Epithelium Organelle Organization Centrosome Tissue Morphogenesis Thioesterase Binding Cytoplasm Golgi Cis Cisterna	Vesicle Cargo Loading Endoplasmic Reticulum Exit Site COPII-coated Vesicle Cargo Loading Endoplasmic Reticulum To Golgi Vesicle-mediated Transport COPII-coated Vesicle Budding Protein Localization To Endoplasmic Reticulum Exit Site Golgi Vesicle Transport Lipoprotein Transport Protein Localization To Endoplasmic Reticulum COPII Vesicle Coat Establishment Of Localization In Cell Cargo Receptor Activity Vesicle Budding From Membrane Vesicle-mediated Transport Intracellular Transport Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Perinuclear Region Of Cytoplasm Amylin Binding Positive Regulation Of Toll Signaling Pathway Endoplasmic Reticulum Lumen Establishment Of Protein Localization Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury ER To Golgi Transport Vesicle Membrane Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Regulation Of Lymphocyte Migration Cellular Localization Endoplasmic Reticulum Cytoplasmic Vesicle Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import Positive Regulation Of Estradiol Secretion PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Negative Regulation Of Metaphase/anaphase Transition Of Meiotic Cell Cycle Regulation Of Estradiol Secretion Lewy Body Core Response To Norepinephrine