EPB41L1 and DRD3

Number of citations of the paper that reports this interaction (PMID 12181426)
22

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		EPB41L1	DRD3
Gene Name		erythrocyte membrane protein band 4.1-like 1	dopamine receptor D3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Cytoskeleton Plasma Membrane Extrinsic Component Of Membrane	Plasma Membrane Integral Component Of Plasma Membrane Endocytic Vesicle Cell Projection Apical Part Of Cell
	Molecular Function	Actin Binding Structural Molecule Activity	Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go Protein Binding Drug Binding Protein Domain Specific Binding D1 Dopamine Receptor Binding Dopamine Binding
	Biological Process	Synaptic Transmission Cortical Actin Cytoskeleton Organization	Negative Regulation Of Transcription From RNA Polymerase II Promoter Synaptic Transmission, Dopaminergic Response To Amphetamine Regulation Of Blood Volume By Renin-angiotensin G-protein Coupled Receptor Internalization Cellular Calcium Ion Homeostasis G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Learning Or Memory Learning Locomotory Behavior Positive Regulation Of Cell Proliferation Visual Learning Regulation Of Dopamine Secretion Regulation Of Lipid Metabolic Process Regulation Of CAMP Metabolic Process Negative Regulation Of Sodium:proton Antiporter Activity Positive Regulation Of Cytokinesis Circadian Regulation Of Gene Expression Response To Histamine Social Behavior Gastric Emptying Positive Regulation Of Renal Sodium Excretion Regulation Of Multicellular Organism Growth Response To Cocaine Dopamine Metabolic Process Response To Drug Response To Morphine Regulation Of Circadian Sleep/wake Cycle, Sleep Response To Ethanol Negative Regulation Of Blood Pressure Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Transcription From RNA Polymerase II Promoter Acid Secretion Behavioral Response To Cocaine Negative Regulation Of Oligodendrocyte Differentiation Arachidonic Acid Secretion Negative Regulation Of Protein Secretion Musculoskeletal Movement, Spinal Reflex Action Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Protein Kinase B Signaling Prepulse Inhibition Negative Regulation Of Dopamine Receptor Signaling Pathway Positive Regulation Of Dopamine Receptor Signaling Pathway Regulation Of Locomotion Involved In Locomotory Behavior
Pathways		Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity Trafficking of AMPA receptors Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Transmission across Chemical Synapses
Drugs			Ziprasidone Cabergoline Ropinirole Olanzapine Clozapine Sulpiride Remoxipride Pramipexole Haloperidol Lisuride Apomorphine Risperidone Dopamine Pimozide Domperidone Pergolide Bromocriptine Quetiapine Levodopa Aripiprazole Chlorprothixene Paliperidone Yohimbine Methotrimeprazine Iloperidone Rotigotine Asenapine Amisulpride
Diseases
GWAS		Height ( 23563607)
Protein-Protein Interactions		16 interactors: AGAP2 APP ARHGAP1 DRD2 DRD3 GRIA1 GRIA4 ITPR1 NUMA1 POT1 SRPK2 STARD13 TERF1 YWHAB YWHAQ YWHAZ	15 interactors: CLIC6 EEF1B2 EEF1G EPB41 EPB41L1 EPB41L2 FLNA GIPC1 GNAI1 GRB2 MPDZ NCK1 NCS1 RDX USP48
Entrez ID		2036	1814
HPRD ID		04193	00540
Ensembl ID		ENSG00000088367	ENSG00000151577
Uniprot IDs		B7Z653 Q9H4G0	E9PCM4
PDB IDs
Enriched GO Terms of Interacting Partners?		Neuron-neuron Synaptic Transmission Positive Regulation Of Organelle Organization Regulation Of Signaling Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Catalytic Activity Intracellular Signal Transduction Signal Transduction Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Cell Cycle Regulation Of Locomotion Involved In Locomotory Behavior Negative Regulation Of Dopamine Receptor Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Signal Transduction Signaling Positive Regulation Of Catalytic Activity Cell Communication Receptor Internalization Regulation Of Establishment Of Protein Localization Ionotropic Glutamate Receptor Signaling Pathway Negative Regulation Of Telomere Maintenance Via Telomerase Regulation Of Dopamine Receptor Signaling Pathway Intrinsic Apoptotic Signaling Pathway Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Positive Regulation Of Mitochondrion Organization Regulation Of Protein Localization Positive Regulation Of Signal Transduction Visual Learning Glutamate Receptor Signaling Pathway Visual Behavior Positive Regulation Of Metabolic Process Positive Regulation Of Cell Cycle Process Regulation Of Dopamine Uptake Involved In Synaptic Transmission Cellular Response To Stimulus Regulation Of Organelle Organization Response To Stimulus Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Negative Regulation Of Telomerase Activity Receptor Metabolic Process Associative Learning Regulation Of Telomere Maintenance Via Telomerase Learning Or Memory Positive Regulation Of Renal Sodium Excretion Response To Histamine G-protein Coupled Receptor Internalization Synaptic Transmission, Dopaminergic Positive Regulation Of Apoptotic Process Regulation Of Mitochondrion Organization Positive Regulation Of Programmed Cell Death Positive Regulation Of Hydrolase Activity	Cortical Actin Cytoskeleton Organization Cortical Cytoskeleton Organization Actin Cytoskeleton Organization Actin Filament-based Process Regulation Of Actin Filament Polymerization Platelet Activation Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Cytoskeleton Organization Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cap-dependent Translational Initiation Positive Regulation Of Cap-independent Translational Initiation Cell Activation Cell Projection Assembly Regulation Of Cellular Component Size Regulation Of Protein Complex Assembly Positive Regulation Of Translation In Response To Stress Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Phosphorylation Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress Positive Regulation Of Cytoplasmic Translation Regulation Of Actin Cytoskeleton Organization Regulation Of Protein Catabolic Process Regulation Of Actin Filament-based Process Peptidyl-serine Dephosphorylation Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Actin Filament Polymerization Cell-cell Signaling Blood Coagulation Hemostasis Negative Regulation Of Protein Catabolic Process Positive Regulation Of Protein Polymerization Posttranscriptional Regulation Of Gene Expression Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Regulation Of Protein Stability Phosphatidylinositol-mediated Signaling Regulation Of Cytoskeleton Organization G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Cell Projection Organization Positive Regulation Of Protein Complex Assembly Regulation Of Body Fluid Levels Translational Elongation Synaptic Transmission Wound Healing Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Substrate-dependent Cell Migration, Cell Extension Positive Regulation Of Signal Transduction Branching Involved In Labyrinthine Layer Morphogenesis
Tagcloud ?		11p15 13q21 15q15 17q23 19q13 20q11 avian b4galt5 betaglcnac cytoscan elongation erb erbb4 erythroblastic erythrocyte gains gal galactosyltransferase helicase heterozygozity loh peritoneal polypeptide rtel1 sox6 sry udp xp22 xq26	admissions binary binomial biweekly calls catechol computerized comt crisis exploratory genotyping heterozygote homozygote mcgill met monoamine pain painreportit record rs4680 rs6280 scd ser9gly sickle telephone utilization val val158met zero
Tagcloud (Difference) ?		11p15 13q21 15q15 17q23 19q13 20q11 avian b4galt5 betaglcnac cytoscan elongation erb erbb4 erythroblastic erythrocyte gains gal galactosyltransferase helicase heterozygozity loh peritoneal polypeptide rtel1 sox6 sry udp xp22 xq26	admissions binary binomial biweekly calls catechol computerized comt crisis exploratory genotyping heterozygote homozygote mcgill met monoamine pain painreportit record rs4680 rs6280 scd ser9gly sickle telephone utilization val val158met zero
Tagcloud (Intersection) ?