LRRC1 and CRMP1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		LRRC1	CRMP1
Description		leucine rich repeat containing 1	collapsin response mediator protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Membrane	Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Actin Cytoskeleton Dendrite Growth Cone Midbody Cell Projection Neuronal Cell Body Perikaryon Presynapse Postsynapse
	Molecular Function		Dihydropyrimidinase Activity Protein Binding Hydrolase Activity Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Cyclic Amides Filamin Binding Identical Protein Binding Phosphoprotein Binding
	Biological Process		Nucleobase-containing Compound Metabolic Process Pyrimidine Nucleobase Catabolic Process Nervous System Development Negative Regulation Of Neuron Projection Development Semaphorin-plexin Signaling Pathway Regulation Of Postsynapse Assembly
Pathways		RND2 GTPase cycle	CRMPs in Sema3A signaling
Drugs
Diseases
GWAS		Heel bone mineral density ( 30598549) Hip index ( 34021172) Metabolite levels ( 23823483) Motor coordination ( 34177493)	Blood trace element (Zn levels) ( 23720494) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Metabolite levels ( 23823483) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		6 interacting genes: APP CEP126 CRMP1 DLG1 DLG4 ERBIN	81 interacting genes: AGR2 ALDH2 AMFR ANXA7 AP3M1 ARL15 AXIN1 BID BTBD2 CACNA1A CCDC106 CCL18 CCT7 CDK5RAP2 CDK5RAP3 DDX18 DISC1 DNAJB11 DPYSL2 DUSP4 EEF1D EIF2S2 EPN1 EXOSC8 FAS FTH1 FUBP1 FXR1 GNE GOLGA2 HDHD2 HGS HMGB1 HNRNPH1 HNRNPH3 HNRNPUL1 HSPE1 HTT IL33 KLHL20 LRRC1 LRRK2 LSM2 MAP3K20 MAPK8IP2 MCM3AP MOB4 MRPS12 NAT9 NDUFV2 NVL PAFAH1B3 PFN1 PLA2G2A PMF1 PPP1R8 PSMD11 RACK1 RGL2 RGS2 ROCK1 RPA2 RPS6KA5 RSPH1 RTN4 SAT1 SEPHS1 SERPINB9 SNRPG SPRY2 SRC TFG TK1 TRIP13 TSC22D1 UBE2A UBE2B VCP VIM YAE1 ZNF24
Entrez ID		55227	1400
HPRD ID		06430	03913
Ensembl ID		ENSG00000137269	ENSG00000072832
Uniprot IDs		Q9BTT6	B3KT07 B3KV96 E9PD68 Q14194 Q96I11 X5DNI1
PDB IDs			4B3Z
Enriched GO Terms of Interacting Partners?		Postsynapse Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Synaptic Membrane NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Neuromuscular Junction Acetylcholine Receptor Binding Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Establishment Or Maintenance Of Cell Polarity Regulation Of Long-term Neuronal Synaptic Plasticity Cell Junction Presynapse Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Excitatory Postsynaptic Potential Protein Localization To Postsynaptic Membrane Ionotropic Glutamate Receptor Binding Protein Localization To Postsynapse Ligand-gated Ion Channel Signaling Pathway Cell Adhesion Neuron Projection Organization Chemical Synaptic Transmission Modulation Of Excitatory Postsynaptic Potential Receptor Localization To Synapse Receptor Clustering Glutamate Receptor Signaling Pathway Neuron Projection Trans-synaptic Signaling Synaptic Signaling Regulation Of Neuronal Synaptic Plasticity System Development Protein Localization To Synapse Cytoplasmic Microtubule Organization Protein-containing Complex Localization Regulation Of Receptor Internalization Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Membrane Potential Dendrite Amylin Binding Positive Regulation Of Toll Signaling Pathway Cell Projection Protein Localization To Cell Junction P2Y1 Nucleotide Receptor Binding Basement Membrane Supramolecular Fiber Organization Regulation Of Chemokine Production Regulation Of Non-canonical NF-kappaB Signal Transduction Kinase Binding	Cytoplasm Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cytosol Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Identical Protein Binding RNA Binding Positive Regulation Of Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Proteolysis Protein Binding Protein-containing Complex Organization Organelle Organization Regulation Of Signal Transduction Cytoskeleton Organization Regulation Of Proteolysis Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Programmed Cell Death Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Mitochondrial Membrane Potential Cellular Component Assembly Nucleus Regulation Of Programmed Cell Death Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Apoptotic Process Regulation Of Protein Binding Regulation Of MAPK Cascade Protein-containing Complex Assembly Regulation Of Apoptotic Process Perinuclear Region Of Cytoplasm BAT3 Complex Binding Regulation Of Wnt Signaling Pathway Regulation Of Mitochondrial Depolarization Catabolic Process Positive Regulation Of Autophagy Regulation Of Cellular Response To Stress Regulation Of Protein Metabolic Process Regulation Of CAMKK-AMPK Signaling Cascade Negative Regulation Of Hippo Signaling HULC Complex Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Branching Morphogenesis Of A Nerve Ubiquitin-like Protein Ligase Binding Macromolecule Metabolic Process Microtubule Cytoskeleton Organization
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