RMDN3 and VAMP3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RMDN3	VAMP3
Description		regulator of microtubule dynamics 3	vesicle associated membrane protein 3
Image			No pdb structure
GO Annotations	Cellular Component	Spindle Pole Nucleus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Spindle Cytoskeleton Microtubule Spindle Microtubule Membrane Organelle Membrane Contact Site Intercellular Bridge Mitotic Spindle Pole Presynapse Postsynapse Glutamatergic Synapse	Endosome Early Endosome Cytosol Plasma Membrane Cell Surface Membrane Transport Vesicle Clathrin-coated Vesicle Secretory Granule Clathrin-coated Endocytic Vesicle Membrane Phagocytic Vesicle Membrane SNARE Complex Cytoplasmic Vesicle Early Endosome Membrane Trans-Golgi Network Membrane Neuron Projection Intracellular Membrane-bounded Organelle Synapse Phagocytic Vesicle Perinuclear Region Of Cytoplasm Recycling Endosome Recycling Endosome Membrane
	Molecular Function	Protein Binding Microtubule Binding	SNAP Receptor Activity Protein Binding Syntaxin-1 Binding
	Biological Process	Intracellular Calcium Ion Homeostasis Apoptotic Process Cell Differentiation	Positive Regulation Of Receptor Recycling Positive Regulation Of Immunoglobulin Production Exocytosis Vesicle Docking Involved In Exocytosis Vesicle Fusion Protein Transport Vesicle-mediated Transport Calcium-ion Regulated Exocytosis Substrate Adhesion-dependent Cell Spreading SNARE Complex Assembly Retrograde Transport, Endosome To Golgi Golgi To Plasma Membrane Protein Transport Establishment Of Localization In Cell Membrane Fusion Protein-containing Complex Assembly Mucus Secretion Cellular Response To Type II Interferon Negative Regulation Of Secretion By Cell Regulation Of Histamine Secretion By Mast Cell
Pathways			ER-Phagosome pathway Retrograde transport at the Trans-Golgi-Network Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOQ GTPase cycle RHOH GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle RHOF GTPase cycle
Drugs
Diseases
GWAS		Anxiety and stress-related disorders ( 31116379) Malaria ( 31844061) Refractive error ( 32231278)	Crohn's disease ( 21102463 28067908) DHEAS levels ( 34748635) Inflammatory bowel disease ( 28067908) Morning vs. evening chronotype ( 26835600) Periodontal microbiota ( 22699663) Ulcerative colitis ( 28067908)
Interacting Genes		26 interacting genes: CYB561D2 EGFL8 EMP3 FAM3C GIMAP1 LHFPL5 NRM PELI2 PLP1 PSEN1 SLC13A3 SLC30A8 STX2 STX3 TF TFRC TMEM100 TMEM140 TMEM147 TMEM203 TMEM243 VAMP3 VAPA VKORC1 YWHAB YWHAG	63 interacting genes: ACAP1 AHNAK2 AIG1 APP AQP6 ARL13B BCAP31 BCL2L13 BIK BSCL2 BSND CD79A CIAO2A CLDN7 CLEC14A COMT DDB1 DNAJC5 EBP ELOVL4 ERGIC3 FAM174A FAM209A FAM210B GORAB GPX8 HSD17B13 IKBKG KCNK5 LHFPL5 LMNA MGST2 MGST3 NELFE NEMP1 PDZK1IP1 PLEKHO1 PTGES RETREG3 RMDN3 SAR1A SCN3B SLC10A1 SLC10A6 SLC16A2 SNAP23 STX16 STX1A STX2 STX3 STX4 TM4SF19 TM4SF20 TMEM237 TMEM31 TMEM35A TMEM52B TMEM86B TMPPE TMX2 VAMP2 VEGFD VSIR
Entrez ID		55177	9341
HPRD ID		07687	04711
Ensembl ID		ENSG00000137824	ENSG00000049245
Uniprot IDs		Q96TC7	Q15836 Q6FGG2
PDB IDs		7CC7
Enriched GO Terms of Interacting Partners?		Membrane Organelle Localization By Membrane Tethering Membrane Docking SNAP Receptor Activity SNARE Complex Establishment Of Protein Localization Myeloid Leukocyte Differentiation HFE-transferrin Receptor Complex Membrane Fusion Vesicle Docking Intracellular Protein Localization Clathrin-coated Endocytic Vesicle Membrane Vesicle Positive Regulation Of Receptor Recycling Cytoplasmic Vesicle Intracellular Monoatomic Cation Homeostasis Intracellular Monoatomic Ion Homeostasis Inorganic Ion Homeostasis Vacuole Vesicle Fusion Organelle Membrane Fusion Myeloid Cell Differentiation Melanosome Secretory Granule Perinuclear Region Of Cytoplasm Regulation Of Receptor Recycling Nuclear Membrane Monoatomic Cation Homeostasis Monoatomic Ion Homeostasis Endoplasmic Reticulum Membrane Multicellular Organismal-level Iron Ion Homeostasis Positive Regulation Of Signaling Positive Regulation Of Coagulation Organelle Fusion Intracellular Chemical Homeostasis Response To Iron Ion Vesicle Organization Recycling Endosome Early Endosome Endoplasmic Reticulum Amide Transport Negative Regulation Of Core Promoter Binding High-affinity Sodium:dicarboxylate Symporter Activity Vitamin-K-epoxide Reductase (warfarin-insensitive) Activity Chemical Homeostasis Plasma Membrane Bounded Cell Projection Organization Regulation Of Protein Localization To Nucleus Metal Ion Transport Protein Binding Protein Sequestering Activity	Membrane SNAP Receptor Activity SNARE Complex Vesicle Fusion Organelle Membrane Fusion SNARE Binding Protein Binding Organelle Fusion Glutathione Peroxidase Activity Membrane Fusion Vesicle Docking Exocytosis Organelle Localization By Membrane Tethering SNARE Complex Assembly Secretion By Cell Specific Granule Vesicle Organization Membrane Docking Endoplasmic Reticulum Membrane Signal Release Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex Positive Regulation Of Protein Localization To Cell Surface Endomembrane System Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Endoplasmic Reticulum Secretion Membrane Organization Leukotriene-C4 Synthase Activity Bile Acid:sodium Symporter Activity Glutathione Transferase Activity Positive Regulation Of Synaptic Transmission Cornified Envelope Assembly Cellular Oxidant Detoxification Synaptic Vesicle Exocytosis ATP-dependent Protein Binding Prostanoid Metabolic Process Establishment Of Localization In Cell Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Vesicle-mediated Transport In Synapse Unsaturated Fatty Acid Metabolic Process Regulation Of Protein Localization To Cell Surface Icosanoid Metabolic Process Protein Transport Icosanoid Biosynthetic Process Plasma Membrane Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Glutathione Binding Cellular Detoxification Nuclear Envelope Lumen
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