TMEM38B and AQP1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TMEM38B	AQP1
Description		transmembrane protein 38B	aquaporin 1 (Colton blood group)
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Nuclear Membrane Sarcoplasmic Reticulum Membrane	Nucleus Cytoplasm Plasma Membrane Brush Border Basal Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Axon Brush Border Membrane Nuclear Membrane Sarcolemma Apical Part Of Cell Extracellular Exosome Ankyrin-1 Complex
	Molecular Function	Potassium Channel Activity Protein Binding Identical Protein Binding	Intracellularly CGMP-activated Cation Channel Activity Potassium Channel Activity Water Transmembrane Transporter Activity Protein Binding Ammonium Channel Activity Potassium Ion Transmembrane Transporter Activity Glycerol Transmembrane Transporter Activity Water Channel Activity Channel Activity Transmembrane Transporter Activity Nitric Oxide Transmembrane Transporter Activity Carbon Dioxide Transmembrane Transporter Activity Identical Protein Binding Ephrin Receptor Binding Hydrogen Peroxide Channel Activity
	Biological Process	Ossification Monoatomic Ion Transport Potassium Ion Transport Endoplasmic Reticulum Organization Phospholipid Biosynthetic Process Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Bone Mineralization Monoatomic Ion Transmembrane Transport Lung Alveolus Development Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Establishment Of Localization In Cell Bone Development Lung Epithelial Cell Differentiation Secretion By Lung Epithelial Cell Involved In Lung Growth Extracellular Matrix Constituent Secretion Cellular Response To Caffeine Potassium Ion Transmembrane Transport Release Of Sequestered Calcium Ion Into Cytosol By Endoplasmic Reticulum	Renal Water Homeostasis Glomerular Filtration Renal Water Transport Potassium Ion Transport Water Transport Cell Volume Homeostasis Hyperosmotic Response Intracellular Water Homeostasis Fibroblast Migration Positive Regulation Of Fibroblast Migration Carbon Dioxide Transport Glycerol Transmembrane Transport Cell Migration Sensory Perception Of Pain Cellular Homeostasis CGMP-mediated Signaling Lateral Ventricle Development Pancreatic Juice Secretion Nitric Oxide Transport Establishment Or Maintenance Of Actin Cytoskeleton Polarity Secretion By Cell Cerebrospinal Fluid Secretion Secretory Granule Organization Cellular Response To UV Transepithelial Water Transport Carbon Dioxide Transmembrane Transport Wound Healing Odontogenesis Negative Regulation Of Apoptotic Process Lipid Digestion Positive Regulation Of Angiogenesis Positive Regulation Of Saliva Secretion Positive Regulation Of Fibroblast Proliferation Camera-type Eye Morphogenesis Defense Response To Gram-negative Bacterium Multicellular Organismal-level Water Homeostasis Corticotropin Secretion Establishment Of Localization In Cell Transmembrane Transport Renal Water Absorption Cellular Response To Hydrogen Peroxide Cellular Response To Mechanical Stimulus Cellular Response To Copper Ion Cellular Response To Mercury Ion Cellular Response To Retinoic Acid Cellular Response To CAMP Cellular Response To Hypoxia Cellular Response To Salt Stress Cellular Hyperosmotic Response Cellular Response To Dexamethasone Stimulus Cellular Response To Nitric Oxide Potassium Ion Transmembrane Transport Metanephric Descending Thin Limb Development Metanephric Proximal Straight Tubule Development Metanephric Proximal Convoluted Tubule Segment 2 Development Metanephric Glomerulus Vasculature Development Ammonium Transmembrane Transport Hydrogen Peroxide Transmembrane Transport Monoatomic Cation Transmembrane Transport
Pathways			Erythrocytes take up carbon dioxide and release oxygen Erythrocytes take up oxygen and release carbon dioxide Vasopressin regulates renal water homeostasis via Aquaporins Passive transport by Aquaporins Developmental Lineage of Pancreatic Ductal Cells
Drugs			Acetazolamide B-nonylglucoside Mersalyl
Diseases
GWAS		Age at voice drop ( 27182965) Alcohol consumption (drinks per week) ( 30679032 30643258) Apolipoprotein A1 levels ( 32203549) Bisphosphonate-associated atypical femoral fracture ( 31006051) Blond vs. brown/black hair color ( 30531825) Body mass index ( 28892062) Cognitive decline rate in late mild cognitive impairment ( 26252872) Cutaneous malignant melanoma ( 26237428) Daytime nap ( 33568662) Lung function (FEV1/FVC) ( 30061609) Melanoma ( 28212542) Menarche (age at onset) ( 19448620 29773799 27182965 25231870 21102462) Protein quantitative trait loci ( 18464913) Pubertal anthropometrics ( 23449627) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 28448500)	Fractures ( 30598549) Heel bone mineral density ( 28869591 30598549) hemolysis of donated blood (osmotic) ( 34014839) Huntington's disease progression ( 28642124) Kidney stones ( 31729369) Nephrolithiasis ( 22396660) Systolic blood pressure ( 30224653) Total body bone mineral density ( 29304378) Triglyceride levels ( 34074324) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		1 interacting genes: AQP1	134 interacting genes: ADAMTSL4 AMOT AQP6 BCL2L13 BEGAIN BLZF1 BMF CCDC136 CCDC57 CCDC85B CCNDBP1 CD79A CDR2 CEP44 CLDN5 COMP CPLX4 CREB3 CRTAC1 CSRNP1 CYSRT1 EFEMP2 EPHB2 ESM1 EVI2B FAM161A FAM209A FNDC9 FOS FSD2 GET1 GJB5 GLI1 GOLGA2 GPR37L1 GPRASP3 GPX8 IFT20 IGFBP6 IHO1 IKZF2 IKZF3 IL21R KCNK5 KCTD17 KCTD9 KHDRBS3 KIAA1958 KLHL26 KRT31 KRT33B KRT37 KRT40 KRTAP1-1 KRTAP1-5 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP12-4 KRTAP3-2 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP6-2 KRTAP9-2 KRTAP9-8 LCE1A LDLRAD1 LDOC1 LIME1 LMNA LPXN LRRC59 MDFI MGST3 MID2 MIF4GD MKRN3 MRM1 MTUS2 MUC1 MYF5 NBPF19 NBPF22P NBPF6 NOTCH2NLA NUTM1 PGPEP1 PICK1 PLA2G10 PLSCR2 PPARA PRDM14 PRDM6 RBAK REL RGS17 RGS20 RIMBP3 RNF122 SAR1A SIAH1 SIVA1 SLC15A2 SLC39A2 SPDYA SPRED1 SPRED2 SPRY2 SPRY3 SPRYD7 SSMEM1 TCF4 TMEM237 TMEM38B TMEM45B TMEM80 TMPRSS2 TNK2 TNS2 TRAF1 TRAF2 TRIM23 TRIM37 TRIM41 TRIM42 TRIM7 TRIP6 TSC1 ZBTB39 ZIM2 ZNF16 ZNF398 ZNF792
Entrez ID		55151	358
HPRD ID		15538	00140
Ensembl ID		ENSG00000095209	ENSG00000240583
Uniprot IDs		A0A0A0MRS4 Q9NVV0	A0A024RA31 P29972
PDB IDs			1FQY 1H6I 1IH5 4CSK 6POJ 7UZE 8CT2 8CTE
Enriched GO Terms of Interacting Partners?		Metanephric Descending Thin Limb Development Metanephric Proximal Straight Tubule Development Nitric Oxide Transmembrane Transporter Activity Metanephric Proximal Convoluted Tubule Segment 2 Development Metanephric Glomerulus Vasculature Development Glycerol Transmembrane Transporter Activity Corticotropin Secretion Nitric Oxide Transport Establishment Or Maintenance Of Actin Cytoskeleton Polarity Cerebrospinal Fluid Secretion Renal Water Absorption Carbon Dioxide Transmembrane Transporter Activity Positive Regulation Of Saliva Secretion Glomerulus Vasculature Development Water Transmembrane Transporter Activity Cellular Response To Mercury Ion Transepithelial Water Transport Hydrogen Peroxide Transmembrane Transport Hydrogen Peroxide Channel Activity Potassium Ion Transmembrane Transporter Activity Intracellularly CGMP-activated Cation Channel Activity Carbon Dioxide Transmembrane Transport Lipid Digestion Pancreatic Juice Secretion Ankyrin-1 Complex Glycerol Transmembrane Transport Intracellular Water Homeostasis Renal Water Transport Regulation Of Saliva Secretion Ammonium Channel Activity Polyol Transmembrane Transport Response To Mercury Ion Ammonium Transmembrane Transport Cellular Response To Salt Stress Positive Regulation Of Digestive System Process Epithelial Fluid Transport Metanephric Nephron Tubule Development Lateral Ventricle Development Water Channel Activity Metanephric Tubule Development Metanephric Epithelium Development Carbon Dioxide Transport Cellular Response To Nitric Oxide Positive Regulation Of Fibroblast Migration Glomerular Filtration Cellular Response To Reactive Nitrogen Species Cellular Hyperosmotic Response Renal Water Homeostasis Response To Salt Stress Fibroblast Migration	Intermediate Filament Keratin Filament Protein Binding Identical Protein Binding Negative Regulation Of Lens Fiber Cell Differentiation Hair Cycle Regulation Of Lens Fiber Cell Differentiation Tumor Necrosis Factor Receptor Binding Cellular Developmental Process
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