GABRB3 and AKAP5

Number of citations of the paper that reports this interaction (PubMedID 12595241)
0

Data Source:
HPRD (in vitro, in vivo)

		GABRB3	AKAP5
Description		gamma-aminobutyric acid type A receptor subunit beta3	A-kinase anchoring protein 5
Image
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Chloride Channel Complex Dendritic Spine Synapse Postsynaptic Membrane GABA-ergic Synapse Postsynaptic Specialization Membrane GABA-A Receptor Complex	Endosome Cytosol Plasma Membrane Protein Serine/threonine Phosphatase Complex Cytoplasmic Side Of Plasma Membrane Postsynaptic Density Membrane Dendrite Dendrite Membrane Cell Projection Dendritic Spine Membrane Raft Synapse Postsynaptic Membrane Excitatory Synapse Postsynaptic Recycling Endosome Postsynaptic Recycling Endosome Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity GABA-A Receptor Activity Monoatomic Ion Channel Activity Extracellular Ligand-gated Monoatomic Ion Channel Activity Chloride Channel Activity GABA-gated Chloride Ion Channel Activity Identical Protein Binding Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential	Protein Binding Calmodulin Binding Adenylate Cyclase Binding SH3 Domain Binding Protein Phosphatase 2B Binding Beta-2 Adrenergic Receptor Binding Protein Kinase A Regulatory Subunit Binding Glutamate Receptor Binding GABA Receptor Binding Protein Kinase A Binding Molecular Adaptor Activity Scaffold Protein Binding
	Biological Process	Monoatomic Ion Transport Chloride Transport Signal Transduction Gamma-aminobutyric Acid Signaling Pathway Chemical Synaptic Transmission Nervous System Development Brain Development Learning Memory Response To Xenobiotic Stimulus Reproductive Behavior Cerebellum Development Monoatomic Ion Transmembrane Transport Social Behavior Exploration Behavior Circadian Sleep/wake Cycle, REM Sleep Neuron Development Synaptic Transmission, GABAergic Roof Of Mouth Development Hard Palate Development Inhibitory Postsynaptic Potential Inner Ear Receptor Cell Development Innervation Motor Behavior Cellular Response To Zinc Ion Cellular Response To Histamine Response To Anesthetic Cochlea Development Chloride Transmembrane Transport Inhibitory Synapse Assembly	Signal Transduction Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Chemical Synaptic Transmission Regulation Of Protein Kinase A Signaling Calcineurin-NFAT Signaling Cascade Positive Regulation Of Calcineurin-NFAT Signaling Cascade Positive Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Calcium Ion Import Across Plasma Membrane Positive Regulation Of Endosome To Plasma Membrane Protein Transport
Pathways		Signaling by ERBB4 GABA receptor activation GABA receptor activation	Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Trafficking of AMPA receptors ROBO receptors bind AKAP5 ROBO receptors bind AKAP5
Drugs		Lorazepam Ethchlorvynol Enflurane Temazepam Butabarbital Butalbital Phenytoin Etomidate Talbutal Pentobarbital Clobazam Meprobamate Eszopiclone Alprazolam Lindane Metharbital Chlordiazepoxide Amoxapine Adinazolam Lamotrigine Piperazine Medroxyprogesterone acetate Clorazepic acid Midazolam Flurazepam Isoflurane Primidone Halazepam Propofol Propofol Diazepam Oxazepam Triazolam Ethanol Methoxyflurane Memantine Clonazepam Methyprylon Halothane Desflurane Flumazenil Estazolam Sevoflurane Glutethimide Camazepam Delorazepam Flunitrazepam Ethyl loflazepate Cloxazolam Bromazepam Clotiazepam Fludiazepam Ketazolam Prazepam Quazepam Cinolazepam Nitrazepam Prasterone Taurine Ganaxolone Fospropofol Brotizolam Stiripentol Etizolam Thiocolchicoside Brexanolone Apalutamide Remimazolam Muscimol 1,2-Benzodiazepine Pinazepam Medazepam Loprazolam Doxefazepam Lormetazepam Nordazepam Oxazepam acetate Cinazepam Bentazepam Mexazolam
Diseases
GWAS		Body mass index ( 28892062) Cognitive performance ( 19734545) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Longevity ( 20834067) Pericalcarine cortex volume ( 31530798) Postprandial triglyceride response ( 32603185) Refractive error ( 32231278) Response to methotrexate in juvenile idiopathic arthritis ( 24709693) Spontaneous preterm birth without premature rupture of membranes ( 31194736) Thyroglobulin plasma levels ( 30929638)
Interacting Genes		8 interacting genes: AKAP5 ARFGEF2 MEOX2 PPP2CA PRKACA PRKCA RACK1 UBQLN1	21 interacting genes: ADRB2 CALM1 DLG1 DLG4 FOS GABRB1 GABRB3 IQGAP1 JUN KCNJ2 MDM2 PPP3CA PRKAR1A PRKAR2A PRKAR2B PRKCA RET ROPN1 ROPN1L TP53 TRPV1
Entrez ID		2562	9495
HPRD ID		08844	05255
Ensembl ID		ENSG00000166206	ENSG00000179841
Uniprot IDs		B2RCW8 P28472 X5DQY4	P24588 Q6PG46
PDB IDs		4COF 5O8F 5OJM 6A96 6HUG 6HUJ 6HUK 6HUO 6HUP 6I53 6QFA 7PBD 7PBZ 7PC0 7QN5 7QN6 7QN7 7QN8 7QN9 7QNA 7QNB 7QNC 7QND 7QNE 8PVB 9CSB 9CTJ 9CX7 9CXA 9CXC 9EQG	2H9R 3LL8 5NIN
Enriched GO Terms of Interacting Partners?		GABA Receptor Binding Protein Kinase A Regulatory Subunit Binding Negative Regulation Of Glycolytic Process Through Fructose-6-phosphate Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Transport Perinuclear Region Of Cytoplasm Protein Serine/threonine Phosphatase Complex Positive Regulation Of Establishment Of Protein Localization Vascular Endothelial Cell Response To Fluid Shear Stress Regulation Of Signal Transduction Negative Regulation Of Glycolytic Process Regulation Of Calcium Ion Transmembrane Transport Regulation Of Protein Transport Positive Regulation Of Protein Localization Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of ATP Metabolic Process Regulation Of Establishment Of Protein Localization Regulation Of Vesicle-mediated Transport Regulation Of Cell Communication Regulation Of Signaling Regulation Of Proteasomal Protein Catabolic Process Cellular Response To Fluid Shear Stress Regulation Of Calcium Ion Transport Negative Regulation Of Smoothened Signaling Pathway Response To Fluid Shear Stress Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Intracellular Signal Transduction Regulation Of Glycolytic Process Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Calcium-mediated Signaling Regulation Of Transport Positive Regulation Of Transport Cellular Response To Glucose Stimulus Regulation Of Carbohydrate Catabolic Process RNA Polymerase II CTD Heptapeptide Repeat S7 Phosphatase Activity RNA Polymerase II CTD Heptapeptide Repeat S2 Phosphatase Activity Regulation Of Protein Localization Regulation Of Metal Ion Transport Positive Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Store-operated Calcium Channel Activity Regulation Of ATP Metabolic Process Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Intracellular Signal Transduction Cellular Response To Carbohydrate Stimulus Regulation Of Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Protein Localization To Cell Periphery Regulation Of Purine Nucleotide Metabolic Process	Regulation Of Membrane Potential Intracellular Signal Transduction Response To Metal Ion Signal Transduction Intracellular Signaling Cassette Regulation Of Intracellular Signal Transduction CAMP-dependent Protein Kinase Regulator Activity Regulation Of Biological Quality Regulation Of System Process CAMP-dependent Protein Kinase Complex CAMP-dependent Protein Kinase Inhibitor Activity Regulation Of CAMP/PKA Signal Transduction Regulation Of Muscle System Process Response To Calcium Ion Protein Kinase A Catalytic Subunit Binding Regulation Of Multicellular Organismal Process Dendritic Spine Regulation Of Signal Transduction Ubiquitin Protein Ligase Binding Developmental Process Cellular Response To Metal Ion CAMP Binding Plasma Membrane System Process Glutamatergic Synapse Cellular Response To Actinomycin D Positive Regulation Of Angiotensin-activated Signaling Pathway Negative Regulation Of CAMP/PKA Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Response To Steroid Hormone Enzyme Binding Response To Toxic Substance Regulation Of Postsynaptic Membrane Potential Protein Domain Specific Binding Postsynaptic Membrane Response To Actinomycin D Extracellular Ligand-gated Monoatomic Ion Channel Activity Muscle System Process Cellular Response To UV-C Regulation Of Angiotensin-activated Signaling Pathway Positive Regulation Of Glomerulus Development Learning Or Memory Positive Regulation Of Cell Communication Positive Regulation Of Signaling Ciliary Base Modulation Of Chemical Synaptic Transmission Transcription Factor AP-1 Complex Cellular Response To Histamine Response To Xenobiotic Stimulus
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