GABRB3

Gene Name		gamma-aminobutyric acid (GABA) A receptor, beta 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Junction Chloride Channel Complex Postsynaptic Membrane GABA-A Receptor Complex
	Molecular Function	GABA-A Receptor Activity Extracellular Ligand-gated Ion Channel Activity Chloride Channel Activity GABA-gated Chloride Ion Channel Activity
	Biological Process	Transport Signal Transduction Synaptic Transmission Sensory Perception Of Sound Ion Transmembrane Transport Negative Regulation Of Neuron Apoptotic Process Transmembrane Transport Palate Development Inner Ear Receptor Cell Development Innervation Cellular Response To Histamine Cochlea Development Chloride Transmembrane Transport
Pathways		GABA receptor activation Ion channel transport GABA A receptor activation Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Ligand-gated ion channel transport Orphan transporters Transmission across Chemical Synapses
Drugs
Diseases
GWAS		Cognitive performance ( 19734545) Longevity ( 20834067)
Protein-protein Interactions		8 interactors: AKAP5 ARFGEF2 GNB2L1 MEOX2 PPP2CA PRKACA PRKCA UBQLN1
Entrez ID		2562
HPRD ID		08844
Ensembl ID		ENSG00000166206
Uniprot IDs		B2RCW8 P28472
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of CAMP Metabolic Process Positive Regulation Of Cyclic Nucleotide Metabolic Process Regulation Of CAMP Metabolic Process Positive Regulation Of Dense Core Granule Biogenesis Regulation Of Intracellular Signal Transduction Inactivation Of MAPK Activity Histone H3-T6 Phosphorylation Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of Protein Kinase Activity Negative Regulation Of Kinase Activity Positive Regulation Of CAMP Biosynthetic Process Nuclear Envelope Organization Negative Regulation Of Transferase Activity Negative Regulation Of Protein Phosphorylation Regulation Of Signal Transduction Peptidyl-serine Autophosphorylation Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of MAP Kinase Activity Regulation Of CAMP Biosynthetic Process Desmosome Assembly Negative Regulation Of Glial Cell Apoptotic Process Regulation Of Signaling Regulation Of Cellular Amino Acid Metabolic Process Negative Regulation Of Phosphorylation Negative Regulation Of Glucose Import Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Macrophage Differentiation Nucleus Organization Endomembrane System Organization Desmosome Organization Cell Death Death Positive Regulation Of Metabolic Process Negative Regulation Of Protein Serine/threonine Kinase Activity Energy Reserve Metabolic Process Regulation Of Cellular Ketone Metabolic Process Negative Regulation Of Glucose Transport Regulation Of Platelet Aggregation Induction Of Positive Chemotaxis Positive Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of MAPK Cascade Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Cellular Response To Fibroblast Growth Factor Stimulus Negative Regulation Of Lyase Activity Response To Fibroblast Growth Factor Regulation Of Insulin Secretion Regulation Of Rhodopsin Mediated Signaling Pathway
Tagcloud ?		agonistic alpha6 aminobutyric antiepileptic beta3 compromise dravet dysfunctions epilepsy gabaa gabra1 gabra6 gabrd gabrg2 gamma2 gastaut gated gating hyperpolarization infantile insufficiencies lennox myoclonic nonsense pathomechanisms pentamers seizures spasms