RBM23 and BHLHE40

Number of citations: 56 (PubMedID 25416956)
Data Source: BioGRID (two hybrid)

		RBM23	BHLHE40
Name		RNA binding motif protein 23	basic helix-loop-helix family member e40
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Membrane	Chromatin Nucleus Cytoplasm Nuclear Body
	Molecular Function	Nucleic Acid Binding RNA Binding Protein Binding U1 SnRNP Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Domain Specific Binding Protein Homodimerization Activity BHLH Transcription Factor Binding MRF Binding Protein Heterodimerization Activity Protein Dimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding E-box Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	MRNA Processing RNA Splicing Positive Regulation Of DNA-templated Transcription Regulation Of MRNA Splicing, Via Spliceosome	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Circadian Rhythm Anterior/posterior Pattern Specification Circadian Regulation Of Gene Expression Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of DNA-templated Transcription Rhythmic Process Regulation Of Neurogenesis
Pathways		None	BMAL1:CLOCK,NPAS2 activates circadian expression Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes
GWAS		Cardiovascular death, myocardial infarction or stroke in response to clopidogrel treatment ( 32472697 ) Cognitive ability (MTAG) ( 29186694 ) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203 ) Cortical amyloid beta load ( 29860282 ) Vertical cup-disc ratio (multi-trait analysis) ( 31959993 )	Cognitive function in longevity ( 33607172 ) Medication use (thyroid preparations) ( 31015401 ) Multiple sclerosis ( 31604244 ) Psoriasis vulgaris ( 26626624 ) Serum alkaline phosphatase levels ( 33547301 ) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355 )
Interacting Genes		31 interacting genes: BHLHE40 CDK6 CEP126 CHERP ESR1 FAM9B FBXO7 GTF3C1 KHDC4 MAGEA11 MAGED1 MED31 OGT PGR POLA2 PRMT5 PRR20A PRR20B PRR20C PRR20D PRR20E PTN QKI RBFOX2 RBM25 RBM39 RBM4 RPA1 SRPK1 TRIM27 TUBA4A	91 interacting genes: AAMP AANAT APH1A ATXN1 BHLHE41 BMAL1 BRD7 BYSL CALML3 CCNK CDPF1 CHD3 COX5B CREM DAB1 DAZAP2 DVL3 EHHADH ENO1 FAM83A FBLN1 FXR1 GMCL2 GPSM1 HDAC1 HIVEP1 HNRNPLL KLHDC7B KRTAP1-3 KRTAP19-1 KRTAP19-5 KRTAP19-7 KRTAP23-1 KRTAP6-1 KRTAP6-2 KRTAP8-1 LARP4 LASP1 LMO3 MAGED1 MCRS1 MTCL2 MYOD1 NAA50 NEK6 NOC4L NUMBL PDE6G PFDN5 PHF1 PLEKHB2 POU6F2 PRKAA1 PRR20A PRR20B PRR20C PRR20D PRR20E RAD54L2 RBFOX1 RBM11 RBM23 RBPMS RBPMS2 RHOBTB3 RHOJ ROR2 SETDB1 SIN3A SMAP2 SMARCB1 SMYD1 SOX15 STAT3 TCF3 TENT5A TENT5B TLE5 TOB2 TOLLIP TTC23 TXNL4B UBE2I USP54 VAC14 VENTX VIM WHR1 WT1 ZFHX3 ZHX1
Entrez ID		55147	8553
HPRD ID		15227	16050
Ensembl ID		ENSG00000100461	ENSG00000134107
Uniprot IDs		A0A0S2Z5D9 A0A0S2Z5I1 A0A0S2Z5J3 B7Z8M4 G3XAP0 Q86U06	O14503 Q6IB83
PDB IDs		2CQ4 2DNZ	Not available
GO Terms Enriched among Interactors		Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing Rhythmic Process Regulation Of RNA Splicing Circadian Regulation Of Gene Expression Nucleoplasm Regulation Of MRNA Metabolic Process RNA Splicing Circadian Rhythm Nucleic Acid Binding Positive Regulation Of Oligodendrocyte Differentiation MRNA Processing RNA Metabolic Process Positive Regulation Of Glial Cell Differentiation Regulation Of Oligodendrocyte Differentiation Regulation Of RNA Metabolic Process MRNA Metabolic Process RNA Processing Nucleic Acid Metabolic Process Negative Regulation Of RNA Metabolic Process Nucleus Estrogen Response Element Binding Positive Regulation Of Gliogenesis Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Glial Cell Differentiation Regulation Of Alternative MRNA Splicing, Via Spliceosome Negative Regulation Of DNA-templated Transcription Negative Regulation Of Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Protein-containing Complex Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Regulation Of Fibroblast Proliferation Nuclear Steroid Receptor Activity Cell Development Estrogen Receptor Signaling Pathway Entrainment Of Circadian Clock By Photoperiod Regulation Of Gliogenesis Nuclear Receptor-mediated Signaling Pathway Negative Regulation Of Macromolecule Metabolic Process Nucleobase-containing Compound Metabolic Process Steroid Binding Photoperiodism Regulation Of Circadian Rhythm Entrainment Of Circadian Clock MRNA Binding Negative Regulation Of Hemopoiesis Negative Regulation Of Cell Development	Protein Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process Intermediate Filament Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Developmental Process Regulation Of MRNA Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Chromatin Positive Regulation Of Myoblast Differentiation Regulation Of Developmental Process Regulation Of DNA-templated Transcription Regulation Of Macromolecule Metabolic Process Transcription Regulator Complex Positive Regulation Of Macromolecule Metabolic Process Regulation Of RNA Biosynthetic Process Rhythmic Process Cytoplasmic Stress Granule Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Biosynthetic Process E-box Binding Transcription Corepressor Activity Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Cell Differentiation Positive Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Circadian Regulation Of Gene Expression Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Circadian Rhythm Regulation Of Alternative MRNA Splicing, Via Spliceosome Chromatin Remodeling DNA-binding Transcription Factor Binding Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Differentiation Regulation Of Myoblast Differentiation Regulation Of RNA Splicing Mitogen-activated Protein Kinase Kinase Kinase Binding