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PLEKHJ1 and DNMT3B
Number of citations of the paper that reports this interaction (PMID
21900206
)
27
Data Source:
BioGRID
(two hybrid)
PLEKHJ1
DNMT3B
Gene Name
pleckstrin homology domain containing, family J member 1
DNA (cytosine-5-)-methyltransferase 3 beta
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Nuclear Heterochromatin
Cytoplasm
Intracellular Membrane-bounded Organelle
Molecular Function
Transcription Corepressor Activity
DNA (cytosine-5-)-methyltransferase Activity
Protein Binding
DNA-methyltransferase Activity
Unmethylated CpG Binding
Metal Ion Binding
DNA (cytosine-5-)-methyltransferase Activity, Acting On CpG Substrates
Biological Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
DNA Methylation
Methylation-dependent Chromatin Silencing
Regulation Of Gene Expression By Genetic Imprinting
Response To Ionizing Radiation
DNA Methylation On Cytosine Within A CG Sequence
Gene Expression
Positive Regulation Of Gene Expression
Protein Complex Localization
DNA Methylation On Cytosine
Regulation Of Gene Expression, Epigenetic
Response To Drug
Positive Regulation Of Neuron Differentiation
Negative Regulation Of Gene Expression, Epigenetic
S-adenosylhomocysteine Metabolic Process
S-adenosylmethioninamine Metabolic Process
Positive Regulation Of Histone H3-K4 Methylation
Negative Regulation Of Histone H3-K9 Methylation
Cellular Response To Amino Acid Stimulus
C-5 Methylation Of Cytosine
Pathways
NoRC negatively regulates rRNA expression
Epigenetic regulation of gene expression
Negative epigenetic regulation of rRNA expression
PRC2 methylates histones and DNA
DNA methylation
Drugs
Diseases
GWAS
Inflammatory bowel disease (
23128233
)
Protein-Protein Interactions
7 interactors:
ACVR1
APP
DNMT3B
FAM109A
IKBKG
PPBP
TGFBR1
35 interactors:
BAZ2A
CBX1
CBX3
CBX5
CMTM6
DNMT1
DNMT3A
DNMT3L
DUSP23
EED
EZH2
HDAC1
HDAC2
HELLS
KIF4A
MAP1LC3B
MBD4
NCAPG
NEDD8
NRIP1
PAM16
PCYT2
PLEKHJ1
RPS10
SMARCA5
SMC2
SPI1
SUMO1
SUV39H1
TDG
TSC22D1
UBE2I
UBE2W
WARS
ZBTB18
Entrez ID
55111
1789
HPRD ID
15150
04209
Ensembl ID
ENSG00000104886
ENSG00000088305
Uniprot IDs
K7EN12
Q9NW61
Q9UBC3
PDB IDs
3FLG
3QKJ
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of Cellular Protein Metabolic Process
Pathway-restricted SMAD Protein Phosphorylation
Positive Regulation Of Protein Metabolic Process
Pharyngeal System Development
Positive Regulation Of Gene Expression
Activin Receptor Signaling Pathway
Negative Regulation Of Apoptotic Signaling Pathway
Signal Transduction By Phosphorylation
Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway
Positive Regulation Of Protein Modification Process
Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation
Peptidyl-threonine Phosphorylation
Regulation Of Pathway-restricted SMAD Protein Phosphorylation
Regulation Of Protein Metabolic Process
Regulation Of Protein Phosphorylation
Platelet Degranulation
Inflammatory Response
Locomotion
Positive Regulation Of Cellular Metabolic Process
Regulation Of Phosphorylation
Positive Regulation Of Transcription, DNA-templated
Endocardial Cushion Cell Fate Commitment
Defense Response
Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Regulation Of Phosphorus Metabolic Process
Movement Of Cell Or Subcellular Component
Mesenchymal Cell Development
Positive Regulation Of Macromolecule Biosynthetic Process
Wound Healing
Regulation Of Cell Differentiation
Synaptic Growth At Neuromuscular Junction
Positive Regulation Of Cellular Biosynthetic Process
Regulation Of Signaling
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Mesenchymal Cell Differentiation
Cell Surface Receptor Signaling Pathway
Transforming Growth Factor Beta Receptor Signaling Pathway
Cell Activation
Regulation Of Protein Binding
Response To Wounding
Collateral Sprouting In Absence Of Injury
S-adenosylmethioninamine Metabolic Process
Positive Regulation Of Protein Phosphorylation
Regulation Of Protein Kinase Activity
Positive Regulation Of Metabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Response To Stress
Phosphorylation
Cellular Response To Organic Substance
Negative Regulation Of Gene Expression, Epigenetic
Regulation Of Gene Expression, Epigenetic
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Gene Expression
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Cellular Metabolic Process
DNA Modification
Chromatin Modification
Chromosome Organization
Chromatin Silencing
Chromatin Organization
Gene Silencing
Nucleobase-containing Compound Metabolic Process
DNA Methylation
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Organelle Organization
Cellular Nitrogen Compound Metabolic Process
DNA Metabolic Process
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Nitrogen Compound Metabolic Process
Gene Expression
Regulation Of Gene Expression
Regulation Of Nitrogen Compound Metabolic Process
RNA Biosynthetic Process
Cellular Metabolic Process
Methylation
Transcription, DNA-templated
Histone H3-K9 Modification
Chromatin Remodeling
RNA Metabolic Process
DNA Methylation On Cytosine
Regulation Of Transcription From RNA Polymerase II Promoter
Chromatin Silencing At RDNA
Histone Modification
Peptidyl-lysine Modification
Histone H4 Deacetylation
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
Rhythmic Process
DNA Packaging
Regulation Of Gene Expression By Genetic Imprinting
Hypermethylation Of CpG Island
C-5 Methylation Of Cytosine
Tagcloud
?
cpg
cues
de
dense
dnmt1
dnmts
enhancers
ensure
ensures
establishment
excluded
guide
lethal
localize
methylated
methylation
methylome
methyltransferase
methyltransferases
novo
nucleosomes
observe
preferential
promoters
pwwp
reflects
setd2
transcribed
Tagcloud (Difference)
?
cpg
cues
de
dense
dnmt1
dnmts
enhancers
ensure
ensures
establishment
excluded
guide
lethal
localize
methylated
methylation
methylome
methyltransferase
methyltransferases
novo
nucleosomes
observe
preferential
promoters
pwwp
reflects
setd2
transcribed
Tagcloud (Intersection)
?