PLEKHJ1 and DNMT3B

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		PLEKHJ1	DNMT3B
Description		pleckstrin homology domain containing J1	DNA methyltransferase 3 beta
Image		No pdb structure
GO Annotations	Cellular Component	Early Endosome Trans-Golgi Network Cytosol Recycling Endosome	Nucleus Nucleoplasm Catalytic Complex
	Molecular Function	Protein Binding	DNA Binding Transcription Corepressor Activity DNA (cytosine-5-)-methyltransferase Activity Protein Binding Methyltransferase Activity Zinc Ion Binding DNA-methyltransferase Activity Transferase Activity Metal Ion Binding DNA (cytosine-5-)-methyltransferase Activity, Acting On CpG Substrates
	Biological Process	Receptor Recycling Endosome Organization Retrograde Transport, Endosome To Golgi	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Positive Regulation Of Gene Expression Methylation
Pathways			PRC2 methylates histones and DNA NoRC negatively regulates rRNA expression SUMOylation of DNA methylation proteins DNA methylation Defective pyroptosis
Drugs			Decitabine
Diseases			Other humoral immunodeficiencies, including the following three diseases: Immunodeficiency, centromeric instability, facial anomalies (ICF)-syndrome; kappa light-chain deficiency; Ig heavy chain gene deletions
GWAS		Pulse pressure ( 26390057) Waist-hip index ( 34021172)	Appendicular lean mass ( 33097823) Brain morphology (MOSTest) ( 32665545) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Inflammatory bowel disease ( 23128233) Iron status biomarkers (iron levels) ( 28334935) Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 27863252 32888494) Nicotine dependence ( 28972577) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Prostate cancer ( 29892016) Pulse pressure ( 27841878 30578418) Total cholesterol levels ( 30275531)
Interacting Genes		10 interacting genes: ACVR1 APP DNMT3B IKBKG LAGE3 NTAQ1 PHETA1 PIH1D2 PPBP TGFBR1	39 interacting genes: BAZ2A BUD23 CBX1 CBX3 CBX5 CMTM6 CUL4B DDB1 DNMT1 DNMT3A DNMT3L DUSP23 EED EZH2 H3C1 HDAC1 HDAC2 HELLS KIF4A MAP1LC3B MBD4 NCAPG NEDD8 NRIP1 PAM16 PCYT2 PLEKHJ1 RPS10 SMARCA5 SMC2 SPI1 SUMO1 SUV39H1 TDG TSC22D1 UBE2I UBE2W WARS1 ZBTB18
Entrez ID		55111	1789
HPRD ID		15150	04209
Ensembl ID		ENSG00000104886	ENSG00000088305
Uniprot IDs		K7EIZ3 Q9NW61	A0A8Q3SIG2 Q9UBC3
PDB IDs			3FLG 3QKJ 5CIU 5NR3 5NRR 5NRS 5NRV 5NV0 5NV2 5NV7 5NVO 6KDA 6KDB 6KDL 6KDP 6KDT 6PA7 6R3E 6U8P 6U8V 6U8W 6U8X 6U90 6U91 7O45 7V0E 7X9D 8EIH 8EII 8EIJ 8EIK 8XEE
Enriched GO Terms of Interacting Partners?		Activin Receptor Complex Activin Receptor Activity, Type I Transforming Growth Factor Beta Receptor Activity, Type I Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Transmembrane Receptor Protein Serine/threonine Kinase Activity Activin Binding Regulation Of Apoptotic Signaling Pathway Pharyngeal System Development Platelet Alpha Granule Transforming Growth Factor Beta Binding Regulation Of Extrinsic Apoptotic Signaling Pathway Activin Receptor Signaling Pathway Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Ventricular Septum Morphogenesis Positive Regulation Of SMAD Protein Signal Transduction Negative Regulation Of Apoptotic Signaling Pathway Growth Factor Binding Cellular Response To Growth Factor Stimulus Endocardial Cushion Cell Fate Commitment Protein Homodimerization Activity SMAD Binding Positive Regulation Of Epithelial To Mesenchymal Transition Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Defense Response To Bacterium DNA (cytosine-5-)-methyltransferase Activity, Acting On CpG Substrates Protein-N-terminal Glutamine Amidohydrolase Activity Platelet Alpha Granule Lumen Response To Growth Factor Regulation Of SMAD Protein Signal Transduction Cardiac Septum Morphogenesis Positive Regulation Of Determination Of Dorsal Identity Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import Vascular Endothelial Cell Proliferation Epicardium Morphogenesis Protein-N-terminal Asparagine Amidohydrolase Activity Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium	Epigenetic Regulation Of Gene Expression Heterochromatin Formation Negative Regulation Of Gene Expression, Epigenetic Chromatin Remodeling Heterochromatin Chromatin Organization DNA Methylation-dependent Constitutive Heterochromatin Formation Pericentric Heterochromatin Constitutive Heterochromatin Formation Chromatin Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Chromatin Silencing Complex Negative Regulation Of RNA Metabolic Process Facultative Heterochromatin Formation Epigenetic Programming Of Gene Expression Nucleoplasm Nucleus Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation ESC/E(Z) Complex Negative Regulation Of Metabolic Process DNA Damage Response Cellular Response To Stress Regulation Of Gene Expression RDNA Heterochromatin Formation Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Rhythmic Process Chromosome, Centromeric Region Regulation Of Macromolecule Metabolic Process Chromosome Regulation Of Nucleobase-containing Compound Metabolic Process Histone Deacetylase Complex Chromosome, Telomeric Region Epigenetic Programming In The Zygotic Pronuclei Regulation Of Chromosome Condensation Regulation Of Primary Metabolic Process Chromosomal DNA Methylation Maintenance Following DNA Replication Condensed Nuclear Chromosome Pyrimidine-specific Mismatch Base Pair DNA N-glycosylase Activity NoRC Complex Methylation
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