PLEKHJ1 and LAGE3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PLEKHJ1	LAGE3
Description		pleckstrin homology domain containing J1	L antigen family member 3
Image		No pdb structure
GO Annotations	Cellular Component	Early Endosome Trans-Golgi Network Cytosol Recycling Endosome	EKC/KEOPS Complex Nucleus Nucleoplasm Cytoplasm Nuclear Body
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Receptor Recycling Endosome Organization Retrograde Transport, Endosome To Golgi	TRNA Processing TRNA Threonylcarbamoyladenosine Metabolic Process
Pathways			tRNA modification in the nucleus and cytosol
Drugs
Diseases
GWAS		Pulse pressure ( 26390057) Waist-hip index ( 34021172)
Interacting Genes		10 interacting genes: ACVR1 APP DNMT3B IKBKG LAGE3 NTAQ1 PHETA1 PIH1D2 PPBP TGFBR1	22 interacting genes: AKAP8L CYSRT1 GOLGA6L9 GON7 HSF2BP HYKK KRT40 KRTAP10-8 KRTAP6-3 MID2 MIPOL1 MKRN3 OSGEP PDE9A PLEKHJ1 PNMA1 POP7 PSMB9 TRIM23 TRIM27 TRIM55 VPS37C
Entrez ID		55111	8270
HPRD ID		15150	02087
Ensembl ID		ENSG00000104886	ENSG00000196976
Uniprot IDs		K7EIZ3 Q9NW61	Q14657
PDB IDs			6GWJ
Enriched GO Terms of Interacting Partners?		Activin Receptor Complex Activin Receptor Activity, Type I Transforming Growth Factor Beta Receptor Activity, Type I Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Transmembrane Receptor Protein Serine/threonine Kinase Activity Activin Binding Regulation Of Apoptotic Signaling Pathway Pharyngeal System Development Platelet Alpha Granule Transforming Growth Factor Beta Binding Regulation Of Extrinsic Apoptotic Signaling Pathway Activin Receptor Signaling Pathway Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Ventricular Septum Morphogenesis Positive Regulation Of SMAD Protein Signal Transduction Negative Regulation Of Apoptotic Signaling Pathway Growth Factor Binding Cellular Response To Growth Factor Stimulus Endocardial Cushion Cell Fate Commitment Protein Homodimerization Activity SMAD Binding Positive Regulation Of Epithelial To Mesenchymal Transition Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Defense Response To Bacterium DNA (cytosine-5-)-methyltransferase Activity, Acting On CpG Substrates Protein-N-terminal Glutamine Amidohydrolase Activity Platelet Alpha Granule Lumen Response To Growth Factor Regulation Of SMAD Protein Signal Transduction Cardiac Septum Morphogenesis Positive Regulation Of Determination Of Dorsal Identity Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import Vascular Endothelial Cell Proliferation Epicardium Morphogenesis Protein-N-terminal Asparagine Amidohydrolase Activity Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium	EKC/KEOPS Complex TRNA Threonylcarbamoyladenosine Modification Ubiquitin Protein Ligase Activity Identical Protein Binding Suppression Of Viral Release By Host Negative Regulation Of Viral Transcription Regulation Of Viral Transcription TRNA Threonylcarbamoyladenosine Metabolic Process TRNA Processing Protein Ubiquitination Intermediate Filament Amino Acid Kinase Activity Hydroxylysine Kinase Activity Positive Regulation Of Autophagy Protein Modification By Small Protein Conjugation
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