BANK1 and ITPR1

Number of citations of the paper that reports this interaction (PubMedID 11782428)
36

Data Source:
HPRD (in vivo)

		BANK1	ITPR1
Description		B cell scaffold protein with ankyrin repeats 1	inositol 1,4,5-trisphosphate receptor type 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Perinuclear Region Of Cytoplasm	Nuclear Envelope Nuclear Inner Membrane Nucleolus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Calcineurin Complex Postsynaptic Density Membrane Sarcoplasmic Reticulum Transport Vesicle Membrane Secretory Granule Membrane Platelet Dense Granule Membrane Platelet Dense Tubular Network Platelet Dense Tubular Network Membrane Cytoplasmic Vesicle Protein-containing Complex Synapse Perinuclear Region Of Cytoplasm Schaffer Collateral - CA1 Synapse
	Molecular Function	Protease Binding Signaling Receptor Binding Protein Binding Signaling Adaptor Activity Phospholipase Binding Protein Tyrosine Kinase Binding	Nucleotide Binding Monoatomic Ion Channel Activity Inositol 1,4,5-trisphosphate-gated Calcium Channel Activity Calcium Channel Activity Calcium Ion Binding Protein Binding ATP Binding Calcium Ion Transmembrane Transporter Activity Intracellularly Gated Calcium Channel Activity Calcium Channel Inhibitor Activity Protein Domain Specific Binding Phosphatidylinositol Binding Protein Homodimerization Activity Metal Ion Binding Inositol 1,4,5 Trisphosphate Binding Inositol 1,4,5-trisphosphate Receptor Activity Involved In Regulation Of Postsynaptic Cytosolic Calcium Levels
	Biological Process	MAPK Cascade Regulation Of Immune System Process Signal Transduction Response To Bacterium Negative Regulation Of Interleukin-6 Production B Cell Activation Positive Regulation Of MAPK Cascade Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Translational Initiation Positive Regulation Of Peptidyl-tyrosine Phosphorylation B Cell Receptor Signaling Pathway Negative Regulation Of B Cell Activation Regulation Of Protein Metabolic Process Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction	Cell Morphogenesis Response To Hypoxia Monoatomic Ion Transport Calcium Ion Transport Apoptotic Process Signal Transduction Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Acetylcholine Receptor Signaling Pathway Single Fertilization Post-embryonic Development Regulation Of Autophagy Calcium-mediated Signaling Positive Regulation Of Insulin Secretion Endoplasmic Reticulum Calcium Ion Homeostasis Monoatomic Ion Transmembrane Transport Calcium Import Into The Mitochondrion Epithelial Fluid Transport Positive Regulation Of Apoptotic Process Negative Regulation Of Calcium-mediated Signaling Voluntary Musculoskeletal Movement Release Of Sequestered Calcium Ion Into Cytosol Protein Homotetramerization Regulation Of Cytosolic Calcium Ion Concentration Transmembrane Transport Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Calcium Ion Transmembrane Transport Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration Release Of Sequestered Calcium Ion Into Cytosol By Endoplasmic Reticulum Ligand-gated Ion Channel Signaling Pathway
Pathways			PLC beta mediated events Effects of PIP2 hydrolysis Elevation of cytosolic Ca2+ levels DAG and IP3 signaling Role of phospholipids in phagocytosis FCERI mediated Ca+2 mobilization Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Ca2+ pathway cGMP effects Regulation of insulin secretion VEGFR2 mediated cell proliferation Ion homeostasis Ion homeostasis CLEC7A (Dectin-1) induces NFAT activation FCGR3A-mediated IL10 synthesis Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs			Caffeine 1D-myo-inositol 1,4,5-trisphosphate Glycerin
Diseases			Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS		Adventurousness ( 30643258) Alcohol consumption (heavy vs. light/non-drinkers) ( 31998841) Alzheimer's disease ( 33654092) Autism spectrum disorder or schizophrenia ( 28540026) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Blood pressure ( 22763476) Body size at age 10 ( 32376654) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Chronic lymphocytic leukemia ( 26956414 28165464) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Diastolic blood pressure ( 30224653) General cognitive ability ( 29844566) ghrelin levels ( 33852427) Gut microbiota (beta diversity) ( 27723756) Hand grip strength ( 29691431) Hypertension ( 31879980) Inflammatory bowel disease ( 28067908) Intelligence (MTAG) ( 29326435) Lipid traits (pleiotropy) (HIPO component 1) ( 30289880) Lupus nephritis in systemic lupus erythematosus ( 34127828) Mean platelet volume ( 27863252 32888494) Multisite chronic pain ( 33830993) Refractive error ( 32231278) Schizophrenia ( 29483656) Subcortical volume (MOSTest) ( 32665545) Systemic lupus erythematosus ( 28714469 27399966 26502338 33272962 23273568 18204447) Systolic blood pressure ( 30578418)	Airflow obstruction ( 22837378) Breast cancer ( 23535729) Calcium levels ( 29403010) Diabetic kidney disease ( 26305897) Femur bone mineral density x serum urate levels interaction ( 34046847) Gamma glutamyl transferase levels ( 29403010 33339817) Hand grip strength ( 29691431) HDL cholesterol levels in HIV infection ( 33109212) Hematocrit ( 32888494) Lead levels ( 26025379) Metabolite levels ( 23823483) Multiple sclerosis ( 31604244) Obesity-related traits ( 23251661) Systolic blood pressure ( 26969751) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355) Triglyceride levels ( 32154731 32203549) Uterine fibroids ( 30194396) Weight ( 28552196) Western dietary pattern ( 28644415)
Interacting Genes		4 interacting genes: ITPR1 ITPR2 LYN TRAF6	32 interacting genes: AHCYL1 AKT1 ARHGAP1 BANK1 BCL2 BECN1 BRCA1 CA8 CABP1 CCNB1 CDK1 EPB41L1 ERBB2 ERP44 FKBP1A FYN GRM1 HOMER1 HOMER2 HOMER3 IRAG1 ITPR3 ITPRIP LYN PRKACA PRKCD PRKG1 RHOA RYR2 STARD13 TRPC3 TRPC4
Entrez ID		55024	3708
HPRD ID		09819	00925
Ensembl ID		ENSG00000153064	ENSG00000150995
Uniprot IDs		Q8NDB2	B4DER3 B4DGH1 Q14643 Q59H91
PDB IDs
Enriched GO Terms of Interacting Partners?		Inositol 1,4,5-trisphosphate-gated Calcium Channel Activity Intracellularly Gated Calcium Channel Activity Regulation Of Sequestering Of Calcium Ion Platelet Dense Tubular Network Membrane Calcium Ion Transmembrane Transporter Activity Inositol 1,4,5 Trisphosphate Binding Stimulatory C-type Lectin Receptor Signaling Pathway Cellular Response To Lectin Fc-epsilon Receptor Signaling Pathway Dendritic Cell Differentiation Lipopolysaccharide-mediated Signaling Pathway Toll-like Receptor 4 Signaling Pathway Cell Surface Toll-like Receptor Signaling Pathway Transport Vesicle Membrane Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Sequestering Of Calcium Ion Fc Receptor Signaling Pathway Cell Surface Pattern Recognition Receptor Signaling Pathway Regulation Of MAP Kinase Activity Sarcoplasmic Reticulum Scaffold Protein Binding Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Intracellular Signal Transduction Calcium Channel Activity Calcium Ion Transmembrane Import Into Cytosol Secretory Granule Membrane Phosphatidylinositol Binding Inositol 1,4,5-trisphosphate Receptor Activity Involved In Regulation Of Postsynaptic Cytosolic Calcium Levels Cytoplasmic Side Of Plasma Membrane Perinuclear Region Of Cytoplasm Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Myeloid Leukocyte Differentiation Negative Regulation Of Intracellular Signal Transduction Protein-containing Complex Transmembrane Transporter Binding Intracellular Signaling Cassette Myeloid Leukocyte Differentiation Regulation Of Protein Localization To Cell Periphery Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Oligodendrocyte Progenitor Proliferation Cellular Response To Oxygen-containing Compound Calcium-mediated Signaling Monoatomic Ion Channel Activity Regulation Of Protein Localization Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Leukocyte Proliferation Regulation Of Protein Localization To Membrane Platelet Dense Tubular Network Cell Morphogenesis Cell Cortex	Regulation Of Metal Ion Transport Regulation Of Monoatomic Ion Transport Intracellular Signaling Cassette Regulation Of Calcium Ion Transport Intracellular Signal Transduction Signal Transduction G Protein-coupled Glutamate Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Regulation Of Multicellular Organismal Process Response To Metal Ion Regulation Of Transport Regulation Of Cell Communication Regulation Of Cellular Localization Regulation Of Signal Transduction Regulation Of Signaling G Protein-coupled Glutamate Receptor Binding Regulation Of Calcium Ion Transmembrane Transport Regulation Of Muscle System Process Glutamate Receptor Signaling Pathway Negative Regulation Of Intracellular Signal Transduction Protein Phosphorylation Response To Calcium Ion Calcium Ion Transport Phosphorylation Regulation Of Monoatomic Cation Transmembrane Transport Plasma Membrane Negative Regulation Of Signal Transduction Glutamatergic Synapse Regulation Of System Process Negative Regulation Of Multicellular Organismal Process Regulation Of Muscle Contraction Regulation Of Monoatomic Ion Transmembrane Transport G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Response To Hydrogen Peroxide Negative Regulation Of Signaling Negative Regulation Of Cell Communication Positive Regulation Of Cell Communication Positive Regulation Of Signaling Inositol 1,4,5 Trisphosphate Binding Calcium Ion Transmembrane Transport Regulation Of Store-operated Calcium Entry Regulation Of Cell Activation Negative Regulation Of Apoptotic Process Lymphocyte Proliferation Positive Regulation Of Signal Transduction Cellular Response To Oxygen-containing Compound Calcium Ion Homeostasis Mononuclear Cell Proliferation Protein Kinase Activity
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