BANK1

Description		B cell scaffold protein with ankyrin repeats 1
Image		No pdb structure
GO Annotations	Cellular Component	Perinuclear Region Of Cytoplasm
	Molecular Function	Protease Binding Signaling Receptor Binding Protein Binding Signaling Adaptor Activity Phospholipase Binding Protein Tyrosine Kinase Binding
	Biological Process	MAPK Cascade Regulation Of Immune System Process Signal Transduction Response To Bacterium Negative Regulation Of Interleukin-6 Production B Cell Activation Positive Regulation Of MAPK Cascade Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Translational Initiation Positive Regulation Of Peptidyl-tyrosine Phosphorylation B Cell Receptor Signaling Pathway Negative Regulation Of B Cell Activation Regulation Of Protein Metabolic Process Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Pathways
Drugs
Diseases
GWAS		Adventurousness ( 30643258) Alcohol consumption (heavy vs. light/non-drinkers) ( 31998841) Alzheimer's disease ( 33654092) Autism spectrum disorder or schizophrenia ( 28540026) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Blood pressure ( 22763476) Body size at age 10 ( 32376654) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Chronic lymphocytic leukemia ( 26956414 28165464) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Diastolic blood pressure ( 30224653) General cognitive ability ( 29844566) ghrelin levels ( 33852427) Gut microbiota (beta diversity) ( 27723756) Hand grip strength ( 29691431) Hypertension ( 31879980) Inflammatory bowel disease ( 28067908) Intelligence (MTAG) ( 29326435) Lipid traits (pleiotropy) (HIPO component 1) ( 30289880) Lupus nephritis in systemic lupus erythematosus ( 34127828) Mean platelet volume ( 27863252 32888494) Multisite chronic pain ( 33830993) Refractive error ( 32231278) Schizophrenia ( 29483656) Subcortical volume (MOSTest) ( 32665545) Systemic lupus erythematosus ( 28714469 27399966 26502338 33272962 23273568 18204447) Systolic blood pressure ( 30578418)
Interacting Genes		4 interacting genes: ITPR1 ITPR2 LYN TRAF6
Entrez ID		55024
HPRD ID		09819
Ensembl ID		ENSG00000153064
Uniprot IDs		Q8NDB2
PDB IDs
Enriched GO Terms of Interacting Partners?		Inositol 1,4,5-trisphosphate-gated Calcium Channel Activity Intracellularly Gated Calcium Channel Activity Regulation Of Sequestering Of Calcium Ion Platelet Dense Tubular Network Membrane Calcium Ion Transmembrane Transporter Activity Inositol 1,4,5 Trisphosphate Binding Stimulatory C-type Lectin Receptor Signaling Pathway Cellular Response To Lectin Fc-epsilon Receptor Signaling Pathway Dendritic Cell Differentiation Lipopolysaccharide-mediated Signaling Pathway Toll-like Receptor 4 Signaling Pathway Cell Surface Toll-like Receptor Signaling Pathway Transport Vesicle Membrane Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Sequestering Of Calcium Ion Fc Receptor Signaling Pathway Cell Surface Pattern Recognition Receptor Signaling Pathway Regulation Of MAP Kinase Activity Sarcoplasmic Reticulum Scaffold Protein Binding Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Intracellular Signal Transduction Calcium Channel Activity Calcium Ion Transmembrane Import Into Cytosol Secretory Granule Membrane Phosphatidylinositol Binding Inositol 1,4,5-trisphosphate Receptor Activity Involved In Regulation Of Postsynaptic Cytosolic Calcium Levels Cytoplasmic Side Of Plasma Membrane Perinuclear Region Of Cytoplasm Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Myeloid Leukocyte Differentiation Negative Regulation Of Intracellular Signal Transduction Protein-containing Complex Transmembrane Transporter Binding Intracellular Signaling Cassette Myeloid Leukocyte Differentiation Regulation Of Protein Localization To Cell Periphery Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Oligodendrocyte Progenitor Proliferation Cellular Response To Oxygen-containing Compound Calcium-mediated Signaling Monoatomic Ion Channel Activity Regulation Of Protein Localization Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Leukocyte Proliferation Regulation Of Protein Localization To Membrane Platelet Dense Tubular Network Cell Morphogenesis Cell Cortex
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