UCKL1 and CCR8

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		UCKL1	CCR8
Description		uridine-cytidine kinase 1 like 1	C-C motif chemokine receptor 8
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Plasma Membrane External Side Of Plasma Membrane Membrane
	Molecular Function	Nucleotide Binding Uridine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Cytidine Kinase Activity	G Protein-coupled Receptor Activity Chemokine Receptor Activity Coreceptor Activity C-C Chemokine Receptor Activity C-C Chemokine Binding
	Biological Process	Pyrimidine-containing Compound Salvage CMP Biosynthetic Process Nucleobase-containing Compound Biosynthetic Process Pyrimidine Nucleoside Salvage UMP Salvage CTP Salvage Nucleobase-containing Small Molecule Metabolic Process Carbohydrate Derivative Biosynthetic Process	Chemotaxis Immune Response Cell Adhesion Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Cell Chemotaxis Chemokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus
Pathways		Pyrimidine salvage	Chemokine receptors bind chemokines G alpha (i) signalling events
Drugs		5-O-phosphono-alpha-D-ribofuranosyl diphosphate Uracil Uridine monophosphate Guanosine-5'-Triphosphate
Diseases
GWAS		Prostate cancer ( 23535732)	Daytime sleep phenotypes ( 27126917) Medication use (thyroid preparations) ( 31015401)
Interacting Genes		1 interacting genes: CCR8	19 interacting genes: ATP2A1 CCL1 CCL16 CCL17 CCL4 EI24 ERGIC3 GABBR1 GABRD NAGPA PAQR6 PLEKHB1 RTN3 SPNS1 SPP1 THY1 TPST1 TPST2 UCKL1
Entrez ID		54963	1237
HPRD ID		15607	03497
Ensembl ID		ENSG00000198276	ENSG00000179934
Uniprot IDs		Q53HM1 Q9NWZ5	P51685
PDB IDs			8KFX 8KFY 8KFZ 8TLM 8U1U 8XML
Enriched GO Terms of Interacting Partners?		Chemokine Receptor Activity C-C Chemokine Binding C-C Chemokine Receptor Activity Coreceptor Activity Chemokine-mediated Signaling Pathway	Chemokine Activity Eosinophil Migration Eosinophil Chemotaxis Protein-tyrosine Sulfotransferase Activity Cytokine Activity CCR Chemokine Receptor Binding Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Antimicrobial Humoral Response Cell-cell Signaling Signaling Cell Communication Axolemma Cell Chemotaxis Chemokine-mediated Signaling Pathway Granulocyte Chemotaxis Negative Regulation Of Neuron Projection Regeneration 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process Granulocyte Migration Positive Regulation Of Calcium Ion Transport Humoral Immune Response Positive Regulation Of Transport Golgi Apparatus Gamma-aminobutyric Acid Signaling Pathway Myeloid Leukocyte Migration Chemotaxis Leukocyte Chemotaxis Regulation Of Neuron Projection Regeneration Locomotion Positive Regulation Of Leukocyte Migration Synaptic Transmission, GABAergic Extracellular Space Maintenance Of Mitochondrion Location Regulation Of Transport Positive Regulation Of Monoatomic Ion Transport Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Peptidyl-tyrosine Sulfation N-acetylglucosamine-1-phosphodiester Alpha-N-acetylglucosaminidase Activity Calcium-dependent ATPase Activity Positive Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Signal Transduction Relaxation Of Skeletal Muscle H Zone Regulation Of Calcium Ion Transport Positive Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity Positive Regulation Of Calcium Ion Import Into Sarcoplasmic Reticulum Positive Regulation Of Fast-twitch Skeletal Muscle Fiber Contraction Positive Regulation Of Cardiac Muscle Cell Contraction G Protein-coupled Neurotransmitter Receptor Activity Involved In Regulation Of Postsynaptic Membrane Potential G Protein-coupled GABA Receptor Activity G Protein-coupled Receptor Dimeric Complex
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