CHCHD3 and SAMM50

Number of citations of the paper that reports this interaction (PubMedID 34037656)
114

Data Source:
BioGRID (pull down, pull down, affinity chromatography technology)

		CHCHD3	SAMM50
Description		coiled-coil-helix-coiled-coil-helix domain containing 3	SAMM50 sorting and assembly machinery component
Image		No pdb structure
GO Annotations	Cellular Component	SAM Complex Nucleus Cytoplasm Mitochondrion Mitochondrial Inner Membrane Membrane Mitochondrial Crista Junction MICOS Complex Extracellular Exosome MIB Complex	SAM Complex Cytoplasm Mitochondrion Mitochondrial Outer Membrane Membrane Outer Membrane Extracellular Exosome MIB Complex
	Molecular Function	Protein Binding Phosphatase Binding Molecular Adaptor Activity	Protein Binding
	Biological Process	Inner Mitochondrial Membrane Organization Mitochondrial Fusion Cristae Formation	Inner Mitochondrial Membrane Organization Protein Import Into Mitochondrial Matrix Cristae Formation Protein Insertion Into Mitochondrial Outer Membrane
Pathways		Mitochondrial protein import Cristae formation	Mitochondrial protein import Cristae formation RAC2 GTPase cycle
Drugs
Diseases
GWAS		Chronotype ( 30696823) Food allergy ( 29030101) Intercellular adhesion molecule 1 (red blood cell fatty acid level interaction) ( 28820441) Metabolite levels ( 23823483) Peanut allergy ( 29030101) Smoking status (ever vs never smokers) ( 30643258) Urinary potassium excretion ( 31409800)	Alanine aminotransferase levels ( 30718733) Cholesterol, total ( 26780889) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Hematological and biochemical traits ( 20139978) Liver enzyme levels ( 18940312) Liver enzyme levels (alanine transaminase) ( 22001757) Metabolite levels ( 23823483) Nonalcoholic fatty liver disease ( 22719876 29271184 29385134 34841290) Nonalcoholic steatohepatitis-derived hepatocellular carcinoma ( 29385134) Pediatric non-alcoholic fatty liver disease activity score ( 23535911) Total cholesterol levels ( 28334899) Type 2 diabetes ( 30054458)
Interacting Genes		40 interacting genes: AMOTL2 ANKS1A ARMC7 BLZF1 CALCOCO2 CATSPERT CBY2 CCDC33 CCDC85B CEP72 CLPP CYSRT1 EFHC1 ENKD1 FANCL GMCL2 GOLGA2 KANK2 KRT40 KRTAP4-12 LMO1 LZTS2 NBPF19 NOTCH2NLA NTAQ1 NUDT3 NUTF2 NUTM1 PDE4DIP PPP1CB RAB3IP RBM11 RPGRIP1 SAMM50 SPAG5 SSX2IP TRAF1 TRIM27 UBC USHBP1	10 interacting genes: A1BG CHCHD3 CHCHD6 GABARAP HMGB2 MAP1LC3B MAP1LC3C MEOX2 UBC VDAC1
Entrez ID		54927	25813
HPRD ID		13044	10826
Ensembl ID		ENSG00000106554	ENSG00000100347
Uniprot IDs		A4D1N4 B7Z1X9 C9JRZ6 Q9NX63	Q9Y512
PDB IDs			6YOO 6YOP
Enriched GO Terms of Interacting Partners?		Spindle Organization Cytoplasm Microtubule Organizing Center Organization Cytoskeleton Centrosome Microtubule Cytoskeleton Organization Microtubule-based Process Centrosome Cycle	Cellular Response To Nitrogen Starvation Phosphatidylethanolamine Binding Mitophagy Autophagosome Membrane Autophagosome Maturation Mitochondrial Crista Junction MICOS Complex Autophagy Of Mitochondrion Ceramide Binding Autophagosome SAM Complex MIB Complex Ubiquitin Protein Ligase Binding Autophagosome Assembly Cristae Formation Autophagosome Organization Phospholipid Binding Protein-containing Complex Disassembly Macroautophagy Vacuole Organization Cellular Response To Starvation Inner Mitochondrial Membrane Organization Response To Starvation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Organelle Membrane Cellular Response To Nutrient Levels Endomembrane System Autophagy Microtubule Cellular Response To Stress Non-sequence-specific DNA Binding, Bending Mitochondrion Organelle Organization Negative Regulation Of Calcium Import Into The Mitochondrion Positive Regulation Of Protein K48-linked Ubiquitination Mitochondrial Membrane Organization Extrinsic Apoptotic Signaling Pathway Axoneme Response To Nutrient Levels Somite Specification Voltage-gated Monoatomic Anion Channel Activity Supercoiled DNA Binding Porin Activity Regulation Of Calcium Import Into The Mitochondrion Regulation Of Protein K48-linked Ubiquitination Response To Stress Mitochondrial Permeability Transition Pore Complex DNA Geometric Change Mitochondrial Membrane Neuron-neuron Synaptic Transmission
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