EPRS1 and EEF1D

Number of citations of the paper that reports this interaction (PubMedID 20195357)
57

Data Source:
BioGRID (pull down)

		EPRS1	EEF1D
Description		glutamyl-prolyl-tRNA synthetase 1	eukaryotic translation elongation factor 1 delta
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane Aminoacyl-tRNA Synthetase Multienzyme Complex GAIT Complex Ribonucleoprotein Complex	Fibrillar Center Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Cytosol Eukaryotic Translation Elongation Factor 1 Complex
	Molecular Function	Nucleotide Binding RNA Binding Catalytic Activity Aminoacyl-tRNA Ligase Activity Glutamate-tRNA Ligase Activity Proline-tRNA Ligase Activity Protein Binding ATP Binding Zinc Ion Binding Ligase Activity RNA Stem-loop Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding GTPase Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding Translation Elongation Factor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding Translation Factor Activity, RNA Binding Heat Shock Protein Binding Cadherin Binding DNA-binding Transcription Factor Binding
	Biological Process	Translation Regulation Of Translation TRNA Aminoacylation For Protein Translation Glutamyl-tRNA Aminoacylation Prolyl-tRNA Aminoacylation Negative Regulation Of Translation Cellular Response To Insulin Stimulus TRNA Aminoacylation Cellular Response To Type II Interferon Regulation Of Long-chain Fatty Acid Import Into Cell	Cytoplasmic Translational Elongation Translation Translational Elongation Cellular Response To Heat Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Ionizing Radiation
Pathways		Selenoamino acid metabolism Cytosolic tRNA aminoacylation tRNA modification in the nucleus and cytosol Transcriptional and post-translational regulation of MITF-M expression and activity	Eukaryotic Translation Elongation
Drugs		Glutamic acid Proline 5'-O-(L-Prolylsulfamoyl)adenosine 5'-O-(L-Cysteinylsulfamoyl)adenosine 5'-O-(N-(Alanyl)sulfamoyl)adenosine
Diseases
GWAS			Schizophrenia ( 31268507)
Interacting Genes		93 interacting genes: AIMP2 ARL4D BTG3 CDC42 CEBPA DUS2 DUX4 EEF1D HSP90AA1 HUNK IARS1 LINC01016 LINC01554 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I NEDD4 NELFCD PTEN RARS1 RNF10 SUMO2 SYNCRIP TAB1	45 interacting genes: ALX1 APP ARHGAP21 ASCC2 ATG7 CAMSAP2 CD48 CDK1 CDK9 CEBPA CRMP1 CSNK2A1 CTBP1 CTBP2 ECH1 EEF1G EPRS1 FILNC1 FKBP6 FOS FRA10AC1 GARS1 HEXD KARS1 KTN1 LINC01232 MAP1B NR2F1 POT1 PRKCA RELA RNF20 RNF40 RPS6KA1 SIAH1 SIAH2 SLC26A4-AS1 SNCA TERF1 TINF2 TPT1 UBE2A USP40 USP7 VARS1
Entrez ID		2058	1936
HPRD ID		00703	00560
Ensembl ID		ENSG00000136628	ENSG00000104529
Uniprot IDs		P07814	B2RAR6 P29692
PDB IDs		1FYJ 4HVC 4K86 4K87 4K88 5A1N 5A34 5A5H 5BMU 5V58 5VAD 5Y6L 6IY6 7BBU 7F98 7F99 7F9A 7F9B 7F9C 7F9D 7OSY 7OSZ 7OT0 7OT1 7OT2 7OT3 7X09 7X1O 7Y1H 7Y1W 7Y28 7Y3S	2MVM 2MVN 2N51 5JPO
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Metabolic Process Extracellular Vesicle Negative Regulation Of Translation Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process MRNA Destabilization RNA Destabilization Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Cell Migration Negative Regulation Of Cell Motility Regulation Of Macromolecule Metabolic Process Negative Regulation Of Locomotion Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Negative Regulation Of Cytokine Production Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Angiogenesis Regulation Of Vasculature Development Regulation Of MRNA Stability Regulation Of Metabolic Process Regulation Of Translation Regulation Of RNA Stability Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Developmental Process Negative Regulation Of Protein Metabolic Process Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Cell Migration Regulation Of Endothelial Cell Migration Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Cell Motility Negative Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cell Population Proliferation Negative Regulation Of Endothelial Cell Migration Regulation Of MRNA Metabolic Process	Protein Metabolic Process Shelterin Complex HULC Complex Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Amyloid Fibril Formation Negative Regulation Of Biosynthetic Process Nuclear Telomere Cap Complex Positive Regulation Of Metabolic Process TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity Telomere Capping TRNA Aminoacylation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Identical Protein Binding Nucleic Acid Metabolic Process Diadenosine Tetraphosphate Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Macromolecule Biosynthetic Process White Fat Cell Differentiation Regulation Of Nucleobase-containing Compound Metabolic Process Symbiont-mediated Disruption Of Host Cell PML Body Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Chromatin Binding Nucleobase-containing Compound Metabolic Process Regulation Of Schwann Cell Differentiation Telomere Assembly Chromatin Organization Regulation Of Protein Catabolic Process Telomeric DNA Binding Nucleus Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Response To Interleukin-1 Regulation Of Synapse Assembly Cytosol Negative Regulation Of DNA Biosynthetic Process Response To Cytokine Regulation Of Macromolecule Biosynthetic Process Response To Copper Ion Response To Peptide Regulation Of Establishment Of Protein Localization To Telomere DNA Metabolic Process DNA-binding Transcription Factor Binding Response To Xenobiotic Stimulus Nucleoplasm Regulation Of Primary Metabolic Process Ankyrin Repeat Binding
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