EPRS and EEF1D

Number of citations of the paper that reports this interaction (PMID 20195357)
18

Data Source:
BioGRID (pull down)

		EPRS	EEF1D
Gene Name		glutamyl-prolyl-tRNA synthetase	eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Membrane Aminoacyl-tRNA Synthetase Multienzyme Complex Ribonucleoprotein Complex GAIT Complex	Nucleus Nucleolus Cytoplasm Cytosol Eukaryotic Translation Elongation Factor 1 Complex
	Molecular Function	Glutamate-tRNA Ligase Activity Proline-tRNA Ligase Activity Protein Binding ATP Binding RNA Stem-loop Binding	DNA Binding Translation Elongation Factor Activity Signal Transducer Activity Protein Binding Translation Factor Activity, Nucleic Acid Binding
	Biological Process	TRNA Aminoacylation For Protein Translation Glutamyl-tRNA Aminoacylation Prolyl-tRNA Aminoacylation Protein Complex Assembly Gene Expression Negative Regulation Of Translation Cellular Response To Interferon-gamma	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Translation Translational Elongation Signal Transduction Gene Expression Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cellular Protein Metabolic Process
Pathways		Cytosolic tRNA aminoacylation tRNA Aminoacylation	Translation Eukaryotic Translation Elongation
Drugs		L-Glutamic Acid L-Proline \'5\'-O-(N-(L-Prolyl)-Sulfamoyl)Adenosine 5\'-O-(N-(L-Cysteinyl)-Sulfamoyl)Adenosine \'5\'-O-(N-(L-Alanyl)-Sulfamoyl)Adenosine
Diseases
GWAS
Protein-Protein Interactions		12 interactors: AIMP2 ARL4D DUS2 EEF1D HSP90AA1 IARS NEDD4 NELFCD POU2F1 RARS SYNCRIP TAB1	33 interactors: ARHGAP21 ASCC2 ATG7 CAMSAP2 CD48 CDK1 CRMP1 CSNK2A1 CTBP1 CTBP2 ECH1 EEF1G EPRS ERP27 FOS FRA10AC1 GARS HEXDC KARS KTN1 MAP1B NR2F1 POT1 PRKCA RELA RPS6KA1 SIAH1 SIAH2 SQSTM1 TERF1 TINF2 TPT1 VARS
Entrez ID		2058	1936
HPRD ID		00703	00560
Ensembl ID		ENSG00000136628	ENSG00000104529
Uniprot IDs		P07814	B2RAR6 D3DWK1 P29692
PDB IDs		1FYJ 4HVC
Enriched GO Terms of Interacting Partners?		TRNA Metabolic Process TRNA Aminoacylation For Protein Translation TRNA Aminoacylation RNA Metabolic Process NcRNA Metabolic Process Nitrogen Compound Metabolic Process Translation Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Respiratory System Development Nucleobase-containing Compound Metabolic Process Gene Expression Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Transmission Of Virus Development Involved In Symbiotic Interaction Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Metabolic Process Cellular Nitrogen Compound Metabolic Process Isoleucyl-tRNA Aminoacylation Cellular Amino Acid Metabolic Process Metabolic Process Regulation Of Cellular Protein Metabolic Process Protein Import Into Mitochondrial Outer Membrane Osteoblast Differentiation Viral Process Negative Regulation Of Cellular Metabolic Process CRD-mediated MRNA Stabilization Arginyl-tRNA Aminoacylation Progesterone Receptor Signaling Pathway Olfactory Placode Formation Immune Response Negative Regulation Of Gene Expression Regulation Of Cellular Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Type II Pneumocyte Differentiation Negative Regulation Of Biosynthetic Process Cell Differentiation Positive Regulation Of Metabolic Process Glucocorticoid Receptor Signaling Pathway Activation Of MAPKKK Activity Intracellular Receptor Signaling Pathway Regulation Of Gene Expression Cellular Macromolecule Biosynthetic Process Lens Induction In Camera-type Eye Macromolecule Biosynthetic Process Heart Morphogenesis Positive Regulation Of Cellular Metabolic Process Protein Targeting To Lysosome Negative Regulation Of Sodium Ion Transport	Negative Regulation Of Chromosome Organization Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Protein Metabolic Process Movement Of Cell Or Subcellular Component Response To External Stimulus Negative Regulation Of Telomere Maintenance Regulation Of Chromosome Organization Axonogenesis Regulation Of Telomere Maintenance Via Telomerase Axon Development Negative Regulation Of Cellular Protein Metabolic Process Cell Morphogenesis Involved In Neuron Differentiation Toll-like Receptor 5 Signaling Pathway Negative Regulation Of Cellular Metabolic Process Toll-like Receptor 10 Signaling Pathway Cell Differentiation Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Regulation Of Apoptotic Process Neuron Projection Morphogenesis Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Regulation Of Protein Metabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death MyD88-independent Toll-like Receptor Signaling Pathway Diadenosine Tetraphosphate Biosynthetic Process Regulation Of Telomere Maintenance Toll-like Receptor 3 Signaling Pathway Regulation Of Cell Death Cellular Macromolecule Biosynthetic Process MyD88-dependent Toll-like Receptor Signaling Pathway Viral Genome Replication Cell Morphogenesis Involved In Differentiation Negative Regulation Of Cell Death Macromolecule Biosynthetic Process Regulation Of Cellular Protein Metabolic Process Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Biosynthetic Process Regulation Of Schwann Cell Differentiation Neuron Projection Development Neurotrophin TRK Receptor Signaling Pathway Cell Projection Morphogenesis Nucleobase-containing Compound Metabolic Process Axon Guidance Chemotaxis Neurotrophin Signaling Pathway Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Histone H4 Acetylation
Tagcloud ?		adequate analgesic analgesics assessments caution codeine comparative documentation dying electronic feasible healthcare hospitalised instrument intensity interpretation limitation morphine norwegian old oldest pain palliative paracetamol regard resident retrospective workers young
Tagcloud (Difference) ?		adequate analgesic analgesics assessments caution codeine comparative documentation dying electronic feasible healthcare hospitalised instrument intensity interpretation limitation morphine norwegian old oldest pain palliative paracetamol regard resident retrospective workers young
Tagcloud (Intersection) ?