EPRS and DUS2

Number of citations of the paper that reports this interaction (PMID 15994936)
14

Data Source:
HPRD (in vivo)

		EPRS	DUS2
Gene Name		glutamyl-prolyl-tRNA synthetase	dihydrouridine synthase 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Membrane Aminoacyl-tRNA Synthetase Multienzyme Complex Ribonucleoprotein Complex GAIT Complex	Cytoplasm Mitochondrion Endoplasmic Reticulum
	Molecular Function	Glutamate-tRNA Ligase Activity Proline-tRNA Ligase Activity Protein Binding ATP Binding RNA Stem-loop Binding	Double-stranded RNA Binding Protein Kinase Inhibitor Activity Protein Binding TRNA Dihydrouridine Synthase Activity Flavin Adenine Dinucleotide Binding
	Biological Process	TRNA Aminoacylation For Protein Translation Glutamyl-tRNA Aminoacylation Prolyl-tRNA Aminoacylation Protein Complex Assembly Gene Expression Negative Regulation Of Translation Cellular Response To Interferon-gamma	TRNA Dihydrouridine Synthesis Negative Regulation Of Protein Kinase Activity Oxidation-reduction Process Negative Regulation Of Cell Death
Pathways		Cytosolic tRNA aminoacylation tRNA Aminoacylation
Drugs		L-Glutamic Acid L-Proline \'5\'-O-(N-(L-Prolyl)-Sulfamoyl)Adenosine 5\'-O-(N-(L-Cysteinyl)-Sulfamoyl)Adenosine \'5\'-O-(N-(L-Alanyl)-Sulfamoyl)Adenosine
Diseases
GWAS
Protein-Protein Interactions		12 interactors: AIMP2 ARL4D DUS2 EEF1D HSP90AA1 IARS NEDD4 NELFCD POU2F1 RARS SYNCRIP TAB1	4 interactors: EPRS PVRL2 SMN1 TK1
Entrez ID		2058	54920
HPRD ID		00703	08624
Ensembl ID		ENSG00000136628	ENSG00000167264
Uniprot IDs		P07814	B4DKP8 E7EUN9 Q9NX74
PDB IDs		1FYJ 4HVC
Enriched GO Terms of Interacting Partners?		TRNA Metabolic Process TRNA Aminoacylation For Protein Translation TRNA Aminoacylation RNA Metabolic Process NcRNA Metabolic Process Nitrogen Compound Metabolic Process Translation Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Respiratory System Development Nucleobase-containing Compound Metabolic Process Gene Expression Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Transmission Of Virus Development Involved In Symbiotic Interaction Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Metabolic Process Cellular Nitrogen Compound Metabolic Process Isoleucyl-tRNA Aminoacylation Cellular Amino Acid Metabolic Process Metabolic Process Regulation Of Cellular Protein Metabolic Process Protein Import Into Mitochondrial Outer Membrane Osteoblast Differentiation Viral Process Negative Regulation Of Cellular Metabolic Process CRD-mediated MRNA Stabilization Arginyl-tRNA Aminoacylation Progesterone Receptor Signaling Pathway Olfactory Placode Formation Immune Response Negative Regulation Of Gene Expression Regulation Of Cellular Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Type II Pneumocyte Differentiation Negative Regulation Of Biosynthetic Process Cell Differentiation Positive Regulation Of Metabolic Process Glucocorticoid Receptor Signaling Pathway Activation Of MAPKKK Activity Intracellular Receptor Signaling Pathway Regulation Of Gene Expression Cellular Macromolecule Biosynthetic Process Lens Induction In Camera-type Eye Macromolecule Biosynthetic Process Heart Morphogenesis Positive Regulation Of Cellular Metabolic Process Protein Targeting To Lysosome Negative Regulation Of Sodium Ion Transport	Cellular Component Assembly Coreceptor-mediated Virion Attachment To Host Cell Fetal Process Involved In Parturition Prolyl-tRNA Aminoacylation Susceptibility To T Cell Mediated Cytotoxicity Sperm Mitochondrion Organization Skeletal Muscle Cell Proliferation Fusion Of Virus Membrane With Host Plasma Membrane Glutamyl-tRNA Aminoacylation Susceptibility To Natural Killer Cell Mediated Cytotoxicity Thymidine Metabolic Process Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Response To Cortisol Virion Attachment To Host Cell Deoxyribonucleoside Monophosphate Biosynthetic Process Positive Regulation Of Immune Response To Tumor Cell Adhesion Of Symbiont To Host Pyrimidine Nucleoside Salvage Pyrimidine-containing Compound Salvage NcRNA Metabolic Process Positive Regulation Of Mast Cell Activation Acrosome Assembly Establishment Of Mitochondrion Localization Parturition Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Immunity Regulation Of Natural Killer Cell Mediated Cytotoxicity Response To Copper Ion Regulation Of Natural Killer Cell Mediated Immunity Spermatid Nucleus Differentiation Positive Regulation Of Immunoglobulin Mediated Immune Response Regulation Of Mast Cell Activation Mitochondrion Localization Pyrimidine Nucleobase Metabolic Process Secretory Granule Organization Multicellular Organismal Reproductive Process Viral Entry Into Host Cell Spliceosomal SnRNP Assembly Multicellular Organism Reproduction Entry Into Host Cell Pyrimidine Nucleoside Biosynthetic Process Spliceosomal Complex Assembly Protein Complex Assembly Reproduction Protein Homotetramerization Pyrimidine Nucleoside Metabolic Process Single Organism Reproductive Process Positive Regulation Of T Cell Mediated Cytotoxicity Negative Regulation Of Translation Adherens Junction Organization
Tagcloud ?		adequate analgesic analgesics assessments caution codeine comparative documentation dying electronic feasible healthcare hospitalised instrument intensity interpretation limitation morphine norwegian old oldest pain palliative paracetamol regard resident retrospective workers young
Tagcloud (Difference) ?		adequate analgesic analgesics assessments caution codeine comparative documentation dying electronic feasible healthcare hospitalised instrument intensity interpretation limitation morphine norwegian old oldest pain palliative paracetamol regard resident retrospective workers young
Tagcloud (Intersection) ?