TMED9 and MTF2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		TMED9	MTF2
Description		transmembrane p24 trafficking protein 9	metal response element binding transcription factor 2
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GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Synaptic Vesicle Membrane Transport Vesicle COPII-coated ER To Golgi Transport Vesicle Trans-Golgi Network Transport Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm ESC/E(Z) Complex
	Molecular Function	Protein Binding Syntaxin Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Corepressor Binding DNA Binding Chromatin Binding Protein Binding Zinc Ion Binding Metal Ion Binding Histone H3K36me3 Reader Activity
	Biological Process	Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Golgi Organization Positive Regulation Of Organelle Organization Protein Transport Protein Exit From Endoplasmic Reticulum Early Endosome To Golgi Transport COPI Coating Of Golgi Vesicle	Chromatin Organization Segment Specification Stem Cell Population Maintenance Epigenetic Regulation Of Gene Expression Negative Regulation Of Gene Expression, Epigenetic Stem Cell Differentiation Cellular Response To Leukemia Inhibitory Factor
Pathways		COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic	PRC2 methylates histones and DNA
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Bitter alcoholic beverage consumption ( 31046077) Chronotype ( 30696823) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Plasma clusterin levels ( 26545630) Response to lurasidone in schizophrenia ( 29730043) Triglyceride levels ( 32154731)
Interacting Genes		14 interacting genes: AQP9 CDC42 CKMT2 COPZ1 DDX54 ITM2A MTF2 NMT2 PLPPR2 SEC22A SEC23B THAP8 TMEM60 YTHDF1	12 interacting genes: CDKN2D CREB1 GPRASP1 GSK3B KDM1A PIK3R3 PRKD2 PRMT6 SMAD3 SUV39H1 SUV39H2 TMED9
Entrez ID		54732	22823
HPRD ID		09975	14342
Ensembl ID		ENSG00000184840	ENSG00000143033
Uniprot IDs		Q9BVK6	B4DZ69 B4DZG1 Q7Z534 Q9Y483
PDB IDs		9CJK 9CJL	5XFR
Enriched GO Terms of Interacting Partners?			Positive Regulation Of Transforming Growth Factor Beta3 Production Histone H3 Methyltransferase Activity Circadian Rhythm Histone Methyltransferase Activity Histone H3K9 Trimethyltransferase Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of Apoptotic Process Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Programmed Cell Death Histone H3K9 Methyltransferase Activity Rhythmic Process Transcription Cis-regulatory Region Binding Regulation Of Growth Response To Retinoic Acid Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Transcription By RNA Polymerase II Response To Decreased Oxygen Levels Response To Hypoxia Epigenetic Programming In The Zygotic Pronuclei Regulation Of Epithelial To Mesenchymal Transition Response To Oxygen Levels Positive Regulation Of Transforming Growth Factor Beta Production Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Regulation Of Multicellular Organismal Development Methyltransferase Activity Nucleoplasm Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Macromolecule Biosynthetic Process Chromatin Binding Epigenetic Programming Of Gene Expression Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Methylation Regulation Of Striated Muscle Tissue Development Regulation Of Cellular Response To Stress Cell Differentiation Regulation Of Long-term Synaptic Potentiation Regulation Of Muscle Organ Development Regulation Of Developmental Process Positive Regulation Of Cell Migration Regulation Of Cellular Component Organization Negative Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Cell Motility Regulation Of Cell Communication
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