TMED9 and THAP8

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		TMED9	THAP8
Description		transmembrane p24 trafficking protein 9	THAP domain containing 8
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Synaptic Vesicle Membrane Transport Vesicle COPII-coated ER To Golgi Transport Vesicle Trans-Golgi Network Transport Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Extracellular Exosome
	Molecular Function	Protein Binding Syntaxin Binding	DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Golgi Organization Positive Regulation Of Organelle Organization Protein Transport Protein Exit From Endoplasmic Reticulum Early Endosome To Golgi Transport COPI Coating Of Golgi Vesicle
Pathways		COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		14 interacting genes: AQP9 CDC42 CKMT2 COPZ1 DDX54 ITM2A MTF2 NMT2 PLPPR2 SEC22A SEC23B THAP8 TMEM60 YTHDF1	6 interacting genes: DYNLL1 NMI SETDB1 TFIP11 TMED9 TP53
Entrez ID		54732	199745
HPRD ID		09975	15501
Ensembl ID		ENSG00000184840	ENSG00000161277
Uniprot IDs		Q9BVK6	B4DKM9 H9CWI5 Q8NA92
PDB IDs		9CJK 9CJL
Enriched GO Terms of Interacting Partners?			Negative Regulation Of DNA Metabolic Process Negative Regulation Of DNA Replication Regulation Of DNA Metabolic Process Oligodendrocyte Apoptotic Process Negative Regulation Of Fermentation Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Promoter-specific Chromatin Binding Negative Regulation Of Pentose-phosphate Shunt Organelle Organization Regulation Of Neuroblast Proliferation Negative Regulation Of Helicase Activity Oxidative Stress-induced Premature Senescence Negative Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Site Of Double-strand Break Regulation Of DNA Replication Negative Regulation Of G1 To G0 Transition Glucose Catabolic Process To Lactate Via Pyruvate Negative Regulation Of Macromolecule Metabolic Process Germ Cell Nucleus Cellular Response To Actinomycin D Regulation Of Neural Precursor Cell Proliferation Deoxyribonuclease Inhibitor Activity Negative Regulation Of DNA Strand Resection Involved In Replication Fork Processing Regulation Of DNA Strand Resection Involved In Replication Fork Processing Nitric-oxide Synthase Inhibitor Activity Positive Regulation Of Protein K48-linked Ubiquitination Spliceosomal Complex Disassembly U2-type Post-mRNA Release Spliceosomal Complex Negative Regulation Of Metabolic Process Centrosome Histone Deacetylase Regulator Activity Positive Regulation Of Thymocyte Apoptotic Process Positive Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Response To Actinomycin D T Cell Proliferation Involved In Immune Response Cell Activation Involved In Immune Response Regulation Of G1 To G0 Transition Leukocyte Activation Involved In Immune Response Glial Cell Apoptotic Process Cellular Response To UV-C Negative Regulation Of Phosphate Metabolic Process ATP-dependent DNA/DNA Annealing Activity Negative Regulation Of Interferon-alpha Production Histone H3K9 Trimethyltransferase Activity DNA Metabolic Process B Cell Lineage Commitment Regulation Of Pentose-phosphate Shunt Regulation Of Protein K48-linked Ubiquitination Histone H3K9 Monomethyltransferase Activity COPI Coating Of Golgi Vesicle
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