POLG2 and MARCHF5

Number of citations of the paper that reports this interaction (PubMedID 36136752)
6

Data Source:
BioGRID (enzymatic study)

		POLG2	MARCHF5
Description		DNA polymerase gamma 2, accessory subunit	membrane associated ring-CH-type finger 5
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Matrix Gamma DNA Polymerase Complex Mitochondrial Nucleoid	Mitochondrion Mitochondrial Outer Membrane Peroxisome Peroxisomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	DNA Binding Double-stranded DNA Binding DNA-directed DNA Polymerase Activity Protein Binding DNA Polymerase Processivity Factor Activity Identical Protein Binding DNA Polymerase Binding	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding GTPase Binding Ubiquitin Protein Ligase Activity
	Biological Process	In Utero Embryonic Development DNA Replication DNA-templated DNA Replication Mitochondrial DNA Replication Mitochondrion Organization Mitochondrial DNA Metabolic Process DNA Biosynthetic Process Positive Regulation Of DNA-directed DNA Polymerase Activity	Protein Polyubiquitination Cytoplasmic Pattern Recognition Receptor Signaling Pathway Protein Ubiquitination Negative Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Protein K27-linked Ubiquitination NLRP3 Inflammasome Complex Assembly Protein Autoubiquitination Protein K63-linked Ubiquitination Protein Localization To Mitochondrion Protein K48-linked Ubiquitination Regulation Of Mitochondrial Fission Positive Regulation Of Mitochondrial Fission CGAS/STING Signaling Pathway Positive Regulation Of CGAS/STING Signaling Pathway Positive Regulation Of NLRP3 Inflammasome Complex Assembly
Pathways		Transcriptional activation of mitochondrial biogenesis Strand-asynchronous mitochondrial DNA replication
Drugs
Diseases
GWAS		Heel bone mineral density ( 30598549) Refractive error ( 32231278)
Interacting Genes		1 interacting genes: MARCHF5	43 interacting genes: AKTIP ANKS6 AQP6 BIK BNIP1 CGRRF1 CREB3 ERGIC3 FATE1 FIS1 FUNDC1 GPX8 HSD17B13 IMMT MANBAL MAP1B MFN2 ODF4 POLG POLG2 PTPN5 RECQL4 RTN4IP1 SAR1A SCD SGPL1 SOD1 STMN4 TANK TIMMDC1 TMEM139 TMEM14B UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E3 UBE2I UBE2N UBE2T UBE2W UTRN YIF1A
Entrez ID		11232	54708
HPRD ID		09228	07909
Ensembl ID		ENSG00000256525	ENSG00000198060
Uniprot IDs		E5KS15 Q9UHN1	Q9NX47
PDB IDs		2G4C 3IKL 3IKM 4ZTU 4ZTZ 5C51 5C52 5C53 8D33 8D37 8D3R 8D42 8G5I 8G5J 8G5K 8G5L 8G5M 8G5N 8G5O 8G5P 8T7E 8UDK 8UDL 8V54 8V55 8V5R
Enriched GO Terms of Interacting Partners?		CGAS/STING Signaling Pathway Regulation Of Mitochondrial Fission GTPase Binding Protein K27-linked Ubiquitination Negative Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Protein Localization To Mitochondrion Canonical Inflammasome Complex Assembly Positive Regulation Of Mitochondrial Fission NLRP3 Inflammasome Complex Assembly Positive Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of CGAS/STING Signaling Pathway Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of Pattern Recognition Receptor Signaling Pathway Peroxisomal Membrane Protein K63-linked Ubiquitination Protein Autoubiquitination Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Protein K48-linked Ubiquitination Cytoplasmic Pattern Recognition Receptor Signaling Pathway Regulation Of Mitochondrion Organization Peroxisome Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signaling Pathway	Ubiquitin Conjugating Enzyme Activity Protein Monoubiquitination Protein Polyubiquitination Ubiquitin-protein Transferase Activity Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Protein Modification By Small Protein Conjugation Mitochondrial Outer Membrane Cellular Response To Stress Gamma DNA Polymerase Complex Protein Ubiquitination Response To Nutrient Levels Negative Regulation Of TORC1 Signaling Protein Binding Post-translational Protein Modification Protein K63-linked Ubiquitination Mitochondrion Organization Negative Regulation Of TOR Signaling Regulation Of TORC1 Signaling Ubiquitin Protein Ligase Binding Nucleotide Binding DNA Repair Apoptotic Process Mitochondrial DNA Replication Mitochondrion Cell Death Programmed Cell Death DNA Metabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein-containing Complex Regulation Of TOR Signaling TORC1 Signaling DNA Damage Response Protein Autoubiquitination Endoplasmic Reticulum Membrane Endoplasmic Reticulum Response To Stress Mitochondrial DNA Metabolic Process Positive Regulation Of Protein Polyubiquitination Mitochondrial Fusion Ubiquitin-like Protein Transferase Activity Mitochondrial Membrane TOR Signaling DNA-directed DNA Polymerase Activity Proteolysis Involved In Protein Catabolic Process Mitochondrial Calcium Ion Homeostasis Protein Modification Process ATP Binding Protein K6-linked Ubiquitination
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