UGDH

Gene Name		UDP-glucose 6-dehydrogenase
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Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytosol Extracellular Vesicular Exosome
	Molecular Function	UDP-glucose 6-dehydrogenase Activity Electron Carrier Activity NAD Binding
	Biological Process	Gastrulation With Mouth Forming Second UDP-glucose Metabolic Process Glycosaminoglycan Biosynthetic Process UDP-glucuronate Biosynthetic Process Xenobiotic Metabolic Process Small Molecule Metabolic Process Cellular Glucuronidation Oxidation-reduction Process
Pathways		Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency) Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD) Defective UGT1A4 causes hyperbilirubinemia Formation of the active cofactor, UDP-glucuronate Metabolic disorders of biological oxidation enzymes Phase II conjugation Defective UGT1A1 causes hyperbilirubinemia Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD) Glucuronidation Biological oxidations Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) Defective GGT1 causes Glutathionuria (GLUTH) Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)
Drugs		NADH
Diseases
GWAS
Protein-protein Interactions		3 interactors: AK5 RAD51 UGT1A1
Entrez ID		7358
HPRD ID		04535
Ensembl ID		ENSG00000109814
Uniprot IDs		O60701
PDB IDs		2Q3E 2QG4 3ITK 3KHU 3PRJ 3PTZ 3TDK 3TF5 4EDF
Enriched GO Terms of Interacting Partners?		Biphenyl Catabolic Process Bilirubin Conjugation DADP Biosynthetic Process Positive Regulation Of DNA Ligation Cellular Response To Camptothecin Response To Camptothecin Negative Regulation Of Cellular Glucuronidation DNA Recombinase Assembly Flavone Metabolic Process ADP Biosynthetic Process Cellular Response To Organic Cyclic Compound Heme Catabolic Process Xenobiotic Glucuronidation Cellular Response To Ethanol Deoxyribonucleoside Diphosphate Metabolic Process Biphenyl Metabolic Process Xenobiotic Catabolic Process Nucleoside Diphosphate Biosynthetic Process Regulation Of Double-strand Break Repair Via Homologous Recombination DNA Unwinding Involved In DNA Replication ADP Metabolic Process Deoxyribonucleotide Biosynthetic Process Nucleobase-containing Small Molecule Interconversion Flavonoid Biosynthetic Process Flavonoid Glucuronidation Cellular Glucuronidation Negative Regulation Of Steroid Metabolic Process Flavonoid Metabolic Process Regulation Of Double-strand Break Repair Estrogen Metabolic Process Retinoic Acid Metabolic Process Mitotic Recombination Response To Organic Cyclic Compound Drug Metabolic Process Nucleoside Diphosphate Phosphorylation Acute-phase Response Cellular Response To Alkaloid Heme Metabolic Process Reciprocal Meiotic Recombination Pyrimidine Ribonucleotide Biosynthetic Process Cellular Response To Glucocorticoid Stimulus Deoxyribonucleotide Metabolic Process Porphyrin-containing Compound Metabolic Process Cellular Response To Corticosteroid Stimulus Pyrimidine Nucleotide Biosynthetic Process Nucleotide Phosphorylation Cellular Response To Ionizing Radiation Nucleoside Diphosphate Metabolic Process Regulation Of DNA Repair Heterocycle Metabolic Process
Tagcloud ?		aldehyde breakdown bronsted c6 catalysis catalytic catalytically clarifies completes covalently crystallizing crystallographic cys deprotonates e161q gln glu glucuronic hydride hydrolysis incompetent nad nucleophile oxyanion succeeded thioester thiohemiacetal udp undergoes