UGDH and RAD51

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		UGDH	RAD51
Gene Name		UDP-glucose 6-dehydrogenase	RAD51 recombinase
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytosol Extracellular Vesicular Exosome	Nuclear Chromosome Condensed Chromosome Condensed Nuclear Chromosome Lateral Element Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrion Mitochondrial Matrix Microtubule Organizing Center PML Body Perinuclear Region Of Cytoplasm
	Molecular Function	UDP-glucose 6-dehydrogenase Activity Electron Carrier Activity NAD Binding	Damaged DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Protein Binding ATP Binding Protein C-terminus Binding Identical Protein Binding Single-stranded DNA-dependent ATPase Activity DNA Polymerase Binding
	Biological Process	Gastrulation With Mouth Forming Second UDP-glucose Metabolic Process Glycosaminoglycan Biosynthetic Process UDP-glucuronate Biosynthetic Process Xenobiotic Metabolic Process Small Molecule Metabolic Process Cellular Glucuronidation Oxidation-reduction Process	Double-strand Break Repair Via Homologous Recombination DNA Recombinase Assembly DNA Unwinding Involved In DNA Replication DNA Repair Double-strand Break Repair DNA Recombination Mitotic Recombination Cellular Response To DNA Damage Stimulus Meiotic Nuclear Division Reciprocal Meiotic Recombination Regulation Of Double-strand Break Repair Via Homologous Recombination Positive Regulation Of DNA Ligation Protein Homooligomerization Cellular Response To Ionizing Radiation Cellular Response To Camptothecin
Pathways		Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency) Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD) Defective UGT1A4 causes hyperbilirubinemia Formation of the active cofactor, UDP-glucuronate Metabolic disorders of biological oxidation enzymes Phase II conjugation Defective UGT1A1 causes hyperbilirubinemia Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD) Glucuronidation Biological oxidations Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) Defective GGT1 causes Glutathionuria (GLUTH) Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)	Assembly of the RAD51-ssDNA nucleoprotein complex Homologous DNA pairing and strand exchange Meiotic recombination Homologous Recombination Repair Homologous recombination repair of replication-independent double-strand breaks Double-Strand Break Repair Presynaptic phase of homologous DNA pairing and strand exchange
Drugs		NADH
Diseases
GWAS
Protein-Protein Interactions		3 interactors: AK5 RAD51 UGT1A1	42 interactors: ABL1 ATM ATRX BCCIP BLM BRCA1 BRCA2 CASP3 CASP7 CHD3 CHEK1 DMC1 DNAJA3 ERCC2 FANCD2 FBXO18 HID1 HNRNPC IRS1 MDC1 NXF1 PFN1 RAD18 RAD51AP1 RAD51AP2 RAD51C RAD52 RAD54B RAD54L RPA1 RPA3 SFR1 SUMO1 SWI5 SWSAP1 TP53 UBE2I UGDH UHRF2 VIM WRN ZDHHC17
Entrez ID		7358	5888
HPRD ID		04535	01557
Ensembl ID		ENSG00000109814	ENSG00000051180
Uniprot IDs		O60701	Q06609
PDB IDs		2Q3E 2QG4 3ITK 3KHU 3PRJ 3PTZ 3TDK 3TF5 4EDF	1B22 1N0W
Enriched GO Terms of Interacting Partners?		Biphenyl Catabolic Process Bilirubin Conjugation DADP Biosynthetic Process Positive Regulation Of DNA Ligation Cellular Response To Camptothecin Response To Camptothecin Negative Regulation Of Cellular Glucuronidation DNA Recombinase Assembly Flavone Metabolic Process ADP Biosynthetic Process Cellular Response To Organic Cyclic Compound Heme Catabolic Process Xenobiotic Glucuronidation Cellular Response To Ethanol Deoxyribonucleoside Diphosphate Metabolic Process Biphenyl Metabolic Process Xenobiotic Catabolic Process Nucleoside Diphosphate Biosynthetic Process Regulation Of Double-strand Break Repair Via Homologous Recombination DNA Unwinding Involved In DNA Replication ADP Metabolic Process Deoxyribonucleotide Biosynthetic Process Nucleobase-containing Small Molecule Interconversion Flavonoid Biosynthetic Process Flavonoid Glucuronidation Cellular Glucuronidation Negative Regulation Of Steroid Metabolic Process Flavonoid Metabolic Process Regulation Of Double-strand Break Repair Estrogen Metabolic Process Retinoic Acid Metabolic Process Mitotic Recombination Response To Organic Cyclic Compound Drug Metabolic Process Nucleoside Diphosphate Phosphorylation Acute-phase Response Cellular Response To Alkaloid Heme Metabolic Process Reciprocal Meiotic Recombination Pyrimidine Ribonucleotide Biosynthetic Process Cellular Response To Glucocorticoid Stimulus Deoxyribonucleotide Metabolic Process Porphyrin-containing Compound Metabolic Process Cellular Response To Corticosteroid Stimulus Pyrimidine Nucleotide Biosynthetic Process Nucleotide Phosphorylation Cellular Response To Ionizing Radiation Nucleoside Diphosphate Metabolic Process Regulation Of DNA Repair Heterocycle Metabolic Process	DNA Metabolic Process DNA Repair Cellular Response To DNA Damage Stimulus Double-strand Break Repair Via Homologous Recombination Recombinational Repair Double-strand Break Repair DNA Recombination Cellular Response To Stress Response To Stress Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Response To Radiation Cellular Nitrogen Compound Metabolic Process Chromosome Organization Response To Ionizing Radiation Organelle Organization Cell Cycle Nitrogen Compound Metabolic Process Cellular Response To Stimulus DNA Duplex Unwinding DNA Geometric Change Response To Abiotic Stimulus Regulation Of Cell Cycle Response To Stimulus Cell Cycle Process DNA-dependent DNA Replication DNA Replication Signal Transduction In Response To DNA Damage Meiotic Nuclear Division Cellular Response To Ionizing Radiation DNA Conformation Change Positive Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Cell Aging Response To UV Meiotic Cell Cycle Cellular Response To Radiation DNA Catabolic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Cell Cycle Process Cellular Metabolic Process Replication Fork Processing Cellular Response To Hydroxyurea Intrinsic Apoptotic Signaling Pathway Meiosis I Response To Gamma Radiation Signal Transduction By P53 Class Mediator DNA Recombinase Assembly Regulation Of Response To DNA Damage Stimulus
Tagcloud ?		aldehyde breakdown bronsted c6 catalysis catalytic catalytically clarifies completes covalently crystallizing crystallographic cys deprotonates e161q gln glu glucuronic hydride hydrolysis incompetent nad nucleophile oxyanion succeeded thioester thiohemiacetal udp undergoes	boundary box cerevisiae consisting damaging declined delta dosage dsc1 elements enhances fluctuate fluctuation frequency mbf1 mbp1 mcb meiosis meiotic mitotic mlu rad54 recombination saccharomyces spore sporulation swi6 transcript viability
Tagcloud (Difference) ?		aldehyde breakdown bronsted c6 catalysis catalytic catalytically clarifies completes covalently crystallizing crystallographic cys deprotonates e161q gln glu glucuronic hydride hydrolysis incompetent nad nucleophile oxyanion succeeded thioester thiohemiacetal udp undergoes	boundary box cerevisiae consisting damaging declined delta dosage dsc1 elements enhances fluctuate fluctuation frequency mbf1 mbp1 mcb meiosis meiotic mitotic mlu rad54 recombination saccharomyces spore sporulation swi6 transcript viability
Tagcloud (Intersection) ?