UGT1A4 and CYB5A

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		UGT1A4	CYB5A
Description		UDP glucuronosyltransferase family 1 member A4	cytochrome b5 type A
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Cytoplasm Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Retinoic Acid Binding Enzyme Inhibitor Activity UDP-glycosyltransferase Activity Glucuronosyltransferase Activity Transferase Activity Glycosyltransferase Activity Enzyme Binding Protein Homodimerization Activity Protein Heterodimerization Activity	Protein Binding Enzyme Binding Heme Binding Metal Ion Binding
	Biological Process	Lipid Metabolic Process Bilirubin Conjugation Xenobiotic Metabolic Process Steroid Metabolic Process Heme Catabolic Process Negative Regulation Of Fatty Acid Metabolic Process Vitamin D3 Metabolic Process
Pathways		Glucuronidation Heme degradation Defective UGT1A4 causes hyperbilirubinemia Aspirin ADME	Vitamin C (ascorbate) metabolism
Drugs			Dimethyl Propionate Ester Heme Chromium Chromic citrate Chromic nitrate Chromium gluconate Chromium nicotinate Chromous sulfate
Diseases			Methemoglobinemia
GWAS		Bilirubin levels ( 32084209) Hair greying ( 26926045) Liver disease biomarker ( 30576415) Low density lipoprotein cholesterol levels ( 32154731) Plasma norclozapine levels in treatment-resistant schizophrenia ( 30922102) Serum metabolite concentrations in chronic kidney disease ( 33838163) Serum metabolite levels ( 23093944 33031748) Total bilirubin levels ( 29403010) Total bilirubin levels in HIV-1 infection ( 25884002)	Blood protein levels ( 30072576)
Interacting Genes		1 interacting genes: CYB5A	14 interacting genes: CYB5R3 CYCS CYP17A1 CYP1A1 CYP1A2 CYP2A6 CYP2D6 CYP2E1 CYP2W1 CYP3A4 CYP4A11 POR SCD UGT1A4
Entrez ID		54657	1528
HPRD ID		08402	08941
Ensembl ID		ENSG00000244474	ENSG00000166347
Uniprot IDs		P22310	A0A384ME44 P00167
PDB IDs			2I96
Enriched GO Terms of Interacting Partners?		Intracellular Membrane-bounded Organelle Heme Binding Mitochondrial Outer Membrane	Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Iron Ion Binding Heme Binding Monooxygenase Activity Xenobiotic Metabolic Process Oxidoreductase Activity Endoplasmic Reticulum Membrane Lipid Metabolic Process Steroid Metabolic Process Olefinic Compound Metabolic Process Intracellular Membrane-bounded Organelle Small Molecule Metabolic Process Monocarboxylic Acid Metabolic Process Endoplasmic Reticulum Fatty Acid Metabolic Process Epoxygenase P450 Pathway Unsaturated Fatty Acid Metabolic Process Arachidonate Metabolic Process Long-chain Fatty Acid Metabolic Process Secondary Metabolic Process Monoterpenoid Metabolic Process Small Molecule Biosynthetic Process Xenobiotic Catabolic Process Carboxylic Acid Metabolic Process Organic Acid Metabolic Process Terpenoid Metabolic Process Long-chain Fatty Acid Biosynthetic Process Icosanoid Metabolic Process Demethylation Isoprenoid Metabolic Process Fatty Acid Biosynthetic Process Coumarin Metabolic Process Carboxylic Acid Biosynthetic Process Steroid Hydroxylase Activity Toxin Metabolic Process Alcohol Metabolic Process Lipid Biosynthetic Process Retinoid Metabolic Process Diterpenoid Metabolic Process Hormone Metabolic Process Oxygen Binding Lipid Hydroxylation Enzyme Binding Estrogen Metabolic Process Estrogen 16-alpha-hydroxylase Activity Estrogen 2-hydroxylase Activity Oxidative Demethylation Aflatoxin Metabolic Process Alkaloid Metabolic Process
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