UGT1A4

Gene Name		UDP glucuronosyltransferase 1 family, polypeptide A4
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	Retinoic Acid Binding Glucuronosyltransferase Activity Enzyme Binding Protein Homodimerization Activity Protein Heterodimerization Activity
	Biological Process	Porphyrin-containing Compound Metabolic Process Xenobiotic Metabolic Process Flavonoid Biosynthetic Process Cellular Response To Hormone Stimulus Heme Catabolic Process Small Molecule Metabolic Process Cellular Glucuronidation Flavonoid Glucuronidation Xenobiotic Glucuronidation
Pathways		Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency) Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD) Heme degradation Defective UGT1A4 causes hyperbilirubinemia Metabolic disorders of biological oxidation enzymes Phase II conjugation Defective UGT1A1 causes hyperbilirubinemia Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD) Metabolism of porphyrins Glucuronidation Biological oxidations Defective GGT1 causes Glutathionuria (GLUTH) Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)
Drugs
Diseases
GWAS
Protein-protein Interactions		1 interactors: CYB5A
Entrez ID		54657
HPRD ID		08402
Ensembl ID		ENSG00000244474
Uniprot IDs		P22310
PDB IDs
Enriched GO Terms of Interacting Partners?		L-ascorbic Acid Metabolic Process Response To Cadmium Ion Water-soluble Vitamin Metabolic Process Vitamin Metabolic Process Hydrogen Ion Transmembrane Transport Proton Transport Monosaccharide Metabolic Process
Tagcloud ?		accounting car cnv discover esr1 fdr genotyped glucuronidation glucuronosyltransferases livers pharmacogenetic pxr quantified tagsnps tfs udp ugt2b ugt2b10 ugt2b15 ugt2b17 ugt2b4 ugt2b7 ugts