TMEM239 and FGD2

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		TMEM239	FGD2
Gene Name		transmembrane protein 239	FYVE, RhoGEF and PH domain containing 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Integral Component Of Membrane	Ruffle Nucleus Cytoplasm Golgi Apparatus Cytosol Cytoskeleton Lamellipodium Early Endosome Membrane Ruffle Membrane
	Molecular Function		Guanyl-nucleotide Exchange Factor Activity Rho Guanyl-nucleotide Exchange Factor Activity Small GTPase Binding Metal Ion Binding
	Biological Process		Cytoskeleton Organization Small GTPase Mediated Signal Transduction Regulation Of Cell Shape Actin Cytoskeleton Organization Positive Regulation Of Rho GTPase Activity Positive Regulation Of Apoptotic Process Regulation Of Cdc42 GTPase Activity Positive Regulation Of GTPase Activity Filopodium Assembly Neurotrophin TRK Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Apoptotic Signaling Pathway
Pathways			Rho GTPase cycle Signaling by GPCR GPCR downstream signaling Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE Signaling by Rho GTPases NRAGE signals death through JNK G alpha (12/13) signalling events p75 NTR receptor-mediated signalling
Drugs
Diseases
GWAS		White matter integrity ( 23218918)
Protein-Protein Interactions		11 interactors: ADCK3 ATF7 C12orf10 CXCL16 FGD2 LENG1 POLI SDCBP SENP2 USP5 WDYHV1	2 interactors: KLHL12 TMEM239
Entrez ID		100288797	221472
HPRD ID			05478
Ensembl ID		ENSG00000198326	ENSG00000146192
Uniprot IDs		Q6ZU23 Q8WW34	Q7Z6J4
PDB IDs
Enriched GO Terms of Interacting Partners?			COPII Vesicle Coating COPII-coated Vesicle Budding Vesicle Targeting, To, From Or Within Golgi Protein Monoubiquitination Localization Within Membrane Vesicle Targeting Membrane Budding ER To Golgi Vesicle-mediated Transport Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Establishment Of Vesicle Localization Vesicle Organization Vesicle Localization Regulation Of Canonical Wnt Signaling Pathway Golgi Vesicle Transport Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway Establishment Of Organelle Localization
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