TMEM239 and CLDN20

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TMEM239	CLDN20
Description		transmembrane protein 239	claudin 20
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Membrane	Golgi Apparatus Cytosol Plasma Membrane Bicellular Tight Junction Membrane Tight Junction Anchoring Junction
	Molecular Function	Protein Binding	Structural Molecule Activity Protein Binding Identical Protein Binding
	Biological Process		Cell Adhesion Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Bicellular Tight Junction Assembly
Pathways			Tight junction interactions
Drugs
Diseases
GWAS		Estimated glomerular filtration rate ( 31451708) Pulse pressure ( 30224653) White matter integrity ( 23218918)	Dimensional psychopathology (Arousal) ( 29496196) Dimensional psychopathology (Negative) ( 29496196) Waist-hip ratio ( 28552196) Waist-to-hip ratio adjusted for BMI ( 28552196)
Interacting Genes		68 interacting genes: AQP6 ATF7 CD79A CLDN20 CLRN1 COQ8A CREB3L1 CREB3L3 CXCL16 DARS2 DCUN1D1 EBP EMP1 FAM174A FAM209A FBXL19 FFAR2 FGD2 FKBP7 FTHL17 FXYD6 GJA8 GPR101 GPR151 GPR42 LENG1 LNX1 MIEF2 MPP1 MS4A3 MTIF3 MTURN MYG1 NTAQ1 OCIAD1 ODF4 OTULIN PDCD1LG2 PNKP POLI PSCA REEP2 RETREG3 S100B SCAND1 SCN3B SDCBP SENP2 SERINC2 SLC10A1 SLC10A6 SLC18A1 SLC34A2 SLC35H1 SLC71A2 SNX1 SNX2 SPG21 SSMEM1 SYT16 TBRG4 TIMMDC1 TMEM248 TMEM31 TMX2 TRHR UBASH3A USP5	7 interacting genes: ANKRD46 APP CNIH3 IGFBP5 MAL PLP1 TMEM239
Entrez ID		100288797	49861
HPRD ID			13067
Ensembl ID		ENSG00000198326	ENSG00000171217
Uniprot IDs		Q8WW34	A0A140VKA2 P56880
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Protein Binding Retromer, Tubulation Complex Leptin Receptor Binding Bile Acid:sodium Symporter Activity	Structural Constituent Of Myelin Sheath Central Nervous System Myelination Amyloid-beta Complex Dendritic Shaft Growth Cone Lamellipodium Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Trans-synaptic Signaling Chemical Synaptic Transmission Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Cellular Response To CAMP Synaptic Signaling Glial Cell Development Negative Regulation Of Skeletal Muscle Hypertrophy Protein Insertion Into Plasma Membrane Hinge Region Between Urothelial Plaques Of Apical Plasma Membrane Response To CAMP Myelination Axon Ensheathment Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Receptor Ligand Activity Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Insulin-like Growth Factor Binding Protein Complex Membrane Raft Polarization Cell-cell Signaling Response To Purine-containing Compound Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Central Nervous System Development Positive Regulation Of Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Signaling Insulin-like Growth Factor Ternary Complex Protein Localization To Paranode Region Of Axon Regulation Of Extrinsic Apoptotic Signaling Pathway Cell Communication Intermediate-density Lipoprotein Particle
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